Bagher Larijani
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
[ 1 ] - Polymorphisms of Antioxidant’ Genes as a Target for Diabetes Management
Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress that is a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as a main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms inclu...
[ 2 ] - Worldwide trends in scientific publications on association of gut microbiota with obesity
Objective(s): Recent evidence has shown underlying roles of gut dysbiosis and metabolic endotoxemia in obesity and its complications. Despite the large number of experimental and clinical researches performed on gut microbiota and obesity, no bibliometrics’ study has been conducted so far. We aimed to assess the trend of global scientific publications in the field of gut microbiota and obesity....
[ 3 ] - Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma
Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an ex...
[ 4 ] - Liquid Biopsy as a Minimally Invasive Source of Thyroid Cancer Genetic and Epigenetic Alterations
In the blood of cancer patients, some nucleic acid fragments and tumor cells can be found that make it possible to trace tumor changes through a simple blood test called “liquid biopsy”. The main components of liquid biopsy are fragments of DNA and RNA shed by tumors into the bloodstream and circulate freely( ctDNAs and ctRNAs). tumor cells which are shed into the blood (circulating tumor cells...
[ 5 ] - Gut Microbiota Composition in Obese and Normal Weight Adults in Iran
Background and purpose: Increasing prevalence of obesity over the past few decades constitutes a global health challenge. Recent evidence suggests that gut microbiota may contribute to weight control. So, the present study aimed at comparing the frequency of different bacteria in gut microbiota between obese and normal weight people in Iran. Materials and methods: Thirty normal weight (BMI of ...
[ 6 ] - The Role of Probiotics on Controlling Diabetes Mellitus: An Umbrella Review
Background and purpose: There are some evidences about the effects of probiotics on controlling different types of diabetes and reviewing these studies could be of great help in clarifying the efficacy of these dietary supplements in management of diabetes. Thus, we aimed to review the role of probiotics on glycemic control and other biochemical parameters in patients with diabetes. Materials...
[ 7 ] - Comparing the Effects of Live and Pasteurized Akkermansia muciniphila on Management of Obesity and Diabetes
Diabetes and obesity are among the most important metabolic disorders which are of worldwide concern. Today, it has been proven that the diversity and composition of the intestinal microbiota play a key role in the incidence and control of metabolic diseases via regulating the metabolism and immune responses of the host. Previous studies reported links between Akkermansia muciniphila, a commen...
[ 8 ] - The Role of Intestinal Microbiota in Cognitive Disorders
Cognitive disorders are one of the major public health issues in older population worldwide. Problems in forming and storing new memories, short-term memory impairment, and other cognitive problems are common symptoms of cognitive disorders that have no definite treatment yet. Recent studies have shown an association between gut microbiota and cognitive impairments described as microbiota-gut-...
[ 9 ] - Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies
Extracellular vesicles, naturally released from all cell types including bacteria, are of great importance in medical microbiology due to transporting a variety of biomaterials, enzymes, and virulence factors, regulating immunity, and having roles in colonization and initiation of signaling pathways. These vesicles are also secreted from microbiota in the gastrointestinal tract and affect the h...
[ 10 ] - Personalized nutrition and its roles on some metabolic disorders: A narrative review
Introduction: Considering an individual’s characteristics such as genetics along with other characteristics and dietary habits can help to provide an effective diet for prevention and controlling metabolic disorders. Accordingly, in the present study, we aimed to review evidence on personalized nutrition (PN) and its roles in metabolic disorders. Materials and Methods: In the present narrative ...
[ 11 ] - Clinical application of gut microbiota metabolites: A novel opportunity in personalized medicine
Nowadays, metabolomics studies are performed with different approaches to identify biomarkers, clarify the underlying mechanisms of diseases and achieve novel treatment strategies. In this context, gut microbiota-derived metabolites are known as one of the most important mediators of gut microbiota effects on human health and various diseases. Due to the inefficiency of conventional therapies i...
[ 12 ] - Designing an Iran FRAX Model and Defining Intervention and Assessment Thresholds for Osteoporosis
Background and Objectives: The purpose of this study was to adopt and calibrate the fracture risk assessment algorithm FRAX® for the Iranian population and to provide the required guidance on how to apply it in clinical practice. Methods: The age-specific ten-year probability of major osteoporotic fractures was calculated in women with an average BMI to determine the fracture probability a...
[ 13 ] - VISUALIZATION OF KNOWLEDGE FLOW IN INTERPERSONAL SCIENTIFIC COLLABORATION NETWORK ENDOCRINOLOGY AND METABOLISM RESEARCH INSTITUTE
Background: A key aspect of Scientific collaboration increases scientific productivity. This study aimed to draw up a scientific collaboration network of the Endocrinology and Metabolism Research Institute (EMRI) at Tehran University of Medical Sciences. Methods: A Descriptive Cross-Sectional Study was conducted by the Scientometrics method. Data collection from the Scopus and Web of Science C...
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