علیرضا خداوندی
استادیار میکروبیولوژی، گروه زیست شناسی، واحد گچساران، دانشگاه آزاد اسلامی، گچساران، ایران
[ 1 ] - مقایسه میزان بیان ژن ERG 11 کاندیدا آلبیکانس تیمار‌شده با تیموس ولگاریس به‌تنهایی و در ترکیب با منتا اسپیکاتا
مقدمه: بیماری‌های ناشی از بیماری‌زای فرصت‌طلب کاندیدا آلبیکانس به‌طور معمول با داروهای ضد قارچ درمان می‌شوند، هرچند شکست درمان به‌ویژه در میزبان دچار نقص ایمنی شدید محتمل است. مطالعه حاضر با هدف مقایسه میزان بیان ژن ERG11 کاندیدا آلبیکانس تیمار‌شده با تیموس ولگاریس به‌تنهایی و در ترکیب با منتا اسپیکاتا انجام شده است. مواد و روشها: در این مطالعه مقطعی، پروفیل بیان ژن ERG11 کاندیدا آلبیکانس ت...
[ 2 ] - Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans
Background and Purpose: The frequency of opportunistic fungal infections in immunocompromised patients, especially by Candida species, has sharply increased in the last few decades. The objective of this study was to analyse the ergosterol content and gene expression profiling of clinical isolates of fluconazole resistant Candida albicans. Materials and Methods: Sixty clinical samples were ide...
[ 3 ] - Antifungal Activity of Carvacrol on Ergosterol Synthesis in Multidrug Resistant Candida albicans
Introduction: Greatly increased use of antifungal therapies has resulted in the development of multidrug resistant. The phenolic compound carvacrol have been reported to have anti-Candida activity. This work is an attempt to examine effect of carvacrol on ergosterol synthesis against multidrug resistant Candida albicans. Methods: This cross-sectional study has been conducted on 30 immune-compr...
[ 4 ] - Inhibitory Effect of Carvacrol on the Expression of Candida albicans Hyphae-Specific Gene (HWP1)
BACKGROUND AND OBJECTIVE: Candida albicans infection is a problem of growing clinical importance, particularly in immunocompromised populations. This study aimed to investigate the inhibitory effect of carvacrol on the hyphae formation and expression of C. albicans HWP1. METHODS: This cross-sectional study was done over a 6-month period in 2016-2017. Vaginal, mouth and skin surface swabs were...
[ 5 ] - Comparison of the Antifungal Activity of Honey and Fluconazole against Candida albicans in vitro and in an Enteric Candidiasis Mouse Model
Background & Objective: Candidiasis has gained importance due to its increasing prevalence in immunocompromised patients. Antifungal drugs such as fluconazole and amphotericin B are used for the treatment of candidiasis. One of the biggest problems faced in clinical practice is resistance for most of these drugs. The antifungal drugs derived from natural products have helped to overcome this pr...
[ 6 ] - Inhibitory Effect of Fluconazole Combined with Amphotericin B on Fluconazole-Resistant Candida albicans Biofilm Formation
Background & Objective: The incidence of biofilm-related infections caused by Candida albicans has increased dramatically. C. albicans biofilm-related infections are more resistant to antifungal medications. This work was an attempt to examine inhibitory effects of fluconazole in combination with amphotericin B on fluconazole-resistant C. albicans biofilm. Materials & Methods: Fluconazole-...
[ 7 ] - Expression of Lanosterol 14-Demethylase (ERG11) Gene of Three-Drug Combinations in Candida albicans
Patients with impaired immunity are at particular risk of infections with Candida albicans. Antifungal drugs such as azoles commonly used for candidiasis treatment, but drug resistance is one of the most common problems for public health. The aim of this study was to evaluate the expression of lanosterol 14-demethylase (ERG11) gene for three-drug combinations in C. albicans. Disk diffusion and ...
[ 8 ] - The multidrug resistance and production of extended-spectrum beta-lactamases ctx-m, per and ver in Escherichia coli isolates derived from raw dairy samples
The occurrence of extended-spectrum beta-lactamases-producing bacteria is an important public health issue. The aim of this study was to investigate phenotypic and genotypic characteristics regarding the presence of extended spectrum β-lactamase ctx-m, per and ver producing Escherichia coli isolated from raw dairy samples. For this purpose, E. coli were isolated from 247 raw dairy samples (milk...
[ 9 ] - Interaction of Candida albicans with Fluconazole/ Clotrimazole: Effect on Hyphae Formation and Expression of Hyphal Wall Protein 1
Background and Aims: Candida albicans (C. albicans) is the most common opportunistic human pathogen. Therapeutic options for Candida infections are limited to available antifungal drugs. The aim of this study was to investigate the effects of fluconazole/clotrimazole (FLU/CLT) on C. albicans hyphae formation. Materials and Methods: We have established the effectiveness of the combination of FL...
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