HOSSEIN HOSSEINZADEH
From the Faculty of Pharmacy, Department of Pharmacodynamy and Toxicology, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, I.R. Iran
[ 1 ] - CIRCADIAN VARIATION OF THE ACUTE TOXICITY AND NOCICEPTIVE ACTIVITY OF AMINOPHYLLINE IN MICE
The circadian variation of the toxicity and nociceptive actIvity of aminophylline as an important methylxanthine was studied in mice. The animals were housed under controlled light-dark cycles for at least 2 weeks. Acute toxicity was determined by LD50. Hot-plate test was used for determination of thermal pain threshold. Doses of 200, 250, 280 and 340 mg/kg of aminophylline were injected i...
نویسندگان همکار