Fatah Kashanchi

[ 1 ] - Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53

Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellu‌lar genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin i...