Priyanshee V. Gohil

[ 1 ] - Role of Estrogen Receptor-Alpha in an Experimental Model of Bronchial Asthma

Background: Use of hormone replacement therapy (HRT) may increase the risk of adult-onset asthma in women. Various in vitro studies have reported that estradiol stimulates human mast cell lines causing release of allergic mediators which was not observed in estrogen receptor-alpha (ER-alpha) knockout mice. Thus, estrogen might be a key element in occurrence of asthma. In the present study, we p...