Sabbaghian, Marjan
[ 1 ] - Expression Analysis of RNA-Binding Motif Gene on Y Chromosome (RBMY) Protein Isoforms in Testis Tissue and a Testicular Germ Cell Cancer-Derived Cell Line (NT2)
a key factor in spermatogenesis and disorders associated with this protein have been recognized to be related to male infertility. Although it was suggested that this protein could have different functions during germ cell development, no studies have been conducted to uncover the mechanism of this potential function yet. Here, we analyzed the expression pattern of RBMY protein isoforms in test...
[ 2 ] - Varicocelectomy May Improve Results for Sperm Retrieval and Pregnancy Rate in Non-Obstructive Azoospermic Men
Objective Improvement in sperm density and motility after varicocelectomy have been widely reported for men with oligoasthenoteratospermia (OAT),However the value of varicocelectomy in azoospermic men remain controversial.In this study we have evaluated the outcome of microsurgical varicocelectomy in nonobstructive azoospermic (NOA) men with clinical varicocele in five years in royan institute....
[ 3 ] - Sperm Retrieval in Patients with Klinefelter Syndrome: A Skewed Regression Model Analysis
Background The most common chromosomal abnormality due to non-obstructive azoospermia (NOA) is Klinefelter syndrome (KS) which occurs in 1-1.72 out of 500-1000 male infants. The probability of retrieving sperm as the outcome could be asymmetrically different between patients with and without KS, therefore logistic regression analysis is not a well-qualified test for this type of data. This stud...
[ 4 ] - I-3: Tale of The Tail: Candidate Genes Involved in Sperm Flagella Formation
Background ISTS defect in which sperm tail is short and fibrous sheath and axoneme are disorganized, is one of the syndromes that cause male infertility. Although a few studies have been done in this regard, its exact etiology in human is unclear yet. Four candidate genes causing ISTS are SPEF2, RABL2B, and A-kinas anchoring proteins genes (AKAP3 and AKAP4). Proteins which coded by SPEF2 and RA...
[ 5 ] - O-35: Assessment of Genetic Variations of DPY19L2 in Total Globozoospermic Patients Referring to Royan Institute
Background Globozoospermia is a rare but severe teratozoospermia disorder which causes male infertility. Total globozoospermia is diagnosed by the presence of 100% roundheaded spermatozoa lacking an acrosome in semen analysis. Recent studies have shown that in large majority of globozoospermic patients, deletion of a 200 kb segment including the DPY19L2 gene occurs. Among all the genes in this ...
[ 6 ] - O-36: Evaluation of Genetic Variations in Intron 4 and Exon 5 of RABL2B Gene in Infertile Men with Oligoasthenoteratospermia and Immotile Short Tail Sperm Defects
Background One of the main causes of male infertility is defect in structure and function of sperm cells. Infertile men with oligoasthenoteratospermia (OAT) defect, have sperms with abnormalities in count, motility and morphology. Patients with immotile short tail sperm (ISTS) disorder have immotile short-tailed sperm with disorganized axonem, and a significant decrease in sperm counts. Numerou...
[ 7 ] - P-13: The Expression of SOX3 Gene in Human Sertoli Cells of Azoospermic Patient
Background Sertoli cells located in seminiferous tubular basement membrane and surrounds different types of germ cell and they were only somatic cell type that directly contacts germ cells. These cells have Several role like support activities, nutrition of germ cells.During spermatogenesis, expression of SOX3 is necessary for differentiation of spermatogonia A. SOX3 is a transcription factor, ...
[ 8 ] - P-61: Effect of 830 nm Diode LASER Irradiation on Human Sperm Motility
Background Sperm motility is known as an effective parameter in male fertility and it depends on energy consumption. Low level LASER irradiation could increases energy supply to the cell by producing of adenosine triphosphate (ATP). The purpose of this study is to evaluate how the low level LASER irradiation affects the human sperm motility. MaterialsAndMethods Fresh human semen specimens of as...
[ 9 ] - P-118: Triplet Nucleotide Repeats Expansion (CAG and GGN) of Androgen Receptor Gene in Infertile Patients with Abnormal Spermogram
Background s:648:"The infertility has recently been estimated to affect approximately 9% of couples worldwide. Androgens and a functional androgen receptor (AR) are essential for normal development of the male gender, and for maintenance of spermatogenesis throughout the life. Two polymorphic trinucleotide repeats, CAG and GGN, encoding for the amino acids glutamine and glycine, respectively ar...
[ 10 ] - P-119: Survey of Genetic Alterations in Exon1 of Androgen Receptor Gene in Azoospermic Patients
Background Androgen receptor (AR) mediates androgen actions such as initiation and promotion of spermatogenesis and growth of accessory sex organs. There are two trinucleotide polymorphisms (CAG and GGN repeats) in exon1 of AR gene that are vary in length in population. The CAG and GGN repeats association with infertility is still unknown and this study is planned to assess the distribution of ...
[ 11 ] - P-123: Genetic Variation of AKAP3 Gene in Infertile Men with Abnormal Spermogram Referred to Royan Institute
Background One kind of sperm abnormality that leads to men infertility is short flagella sperms. In this defect, fibrous sheath and axoneme are disorganized, the sperms tail is short, the numbers of sperms in the semen fluid reduce and the sperms are immotile. There are also other kinds of oligoasthenoteratozospermia (OAT) disorder that causes infertility in men. A kinas anchoring protein 3 (AK...
[ 12 ] - P-133: Investigation of Genetic Variations in Exon 6 of AKAP4 Gene in Infertile Men with Immotile Short Tail Sperm
Background The immotile short tail sperm (ISTS) defect is one of the disorders that cause male infertility. Men with this condition have immotile short-tail sperm with structural defects in the fibrous sheath(FS). A Kinase Anchoring Protein 4 (AKAP4) is one of the most abundant proteins in the fibrous sheathof sperm flagella and provides scaffold for the correct assembly of FS.Since exon 6 of A...
[ 13 ] - P-134: Effect of Tribulus Terrestris Extract on Sperm Parameters in Male Mouse
Background Spermatogenesis is a process in which the gametes are produced. Dysfunction in any of part of the process could result in infertility. Tribulus terrestris is a flowering plant which traditionally is used to sexual instinct. Reports indicate that this plant could elevate blood levels testosterone and enhance libido. MaterialsAndMethods In this experimental study, twenty six mature inb...
[ 14 ] - A Comparative in vitro Study of the Effect of Eosin B on Asexual Blood Stages and Gametocyte of Plasmodiun falciparum
Background and Objective: Malaria is one of the most life-threatening infectious diseases worldwide. Transmission of the parasite from human to vector mosquitoes is carried out by the gametocyte of the Plasmodium parasite, while these cells are not involved in the symptoms of the disease. The control of the human to mosquito transmission stage of the parasite life cycle by antigametocyte drugs...
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