Mojgan Bandehpour
[ 1 ] - Suppressive Effect of Constructed shRNAs against Apollon Induces Apoptosis and Growth Inhibition in the HeLa Cell Line
Background: Cervical cancer is the second most common female cancer worldwide. Inhibitors of apoptosis proteins (IAPs) block apoptosis; therefore, therapeutic strategies targeting IAPs have attracted the interest of researchers in recent years. Apollon, a member of IAPs, inhibits apoptosis and cell death. RNA interference is a pathway in which small interfering RNA (siRNA) or shRNA (short hairp...
[ 2 ] - کلونینگ و بیان پروتئین M2 ویروس آنفلوانزا H1N1 در باکتری Ecoli سویه BL21(DE3)
سابقه و هدف: ویروس انفلوانزا A یکی از عوامل اصلی مرگ ومیر سالیانه می باشد و از سال 1960 میلادی بر علیه آن واکسن موثر در دسترس بوده است. تغییرات مداوم آنتی ژنیک ویروس چالش بزرگی در مسیر تولید سالیانه واکسن می باشد. در حال حاضر محققین روی آنتی ژنهای ثابت ویروس مطالعه می کنند. پروتئینM2 یک کانال یونی درون پوشش ویروس انفلوانزای A تشکیل می دهد که در عفونت زایی آن موثر است. این پروتئین حفاظت شده ا...
[ 3 ] - Heterologous Expression of Human IL-29 (IFN-λ1) in Iranian Lizard Leishmania
Background: Interferons with diffrent functions such as antiviral, antiproliferative and immunomodulatory actions are effctive <span style="font-varia...
[ 4 ] - Using Recombinant Chlamydia Major Outer Membrane Protein (MOMP) in ELISA Diagnostic Kit
Chlamydia trachomatis is one of the main causes of Sexually Transmitted Diseases (STDs) such as prostatitis and epididymitis in men and cervicitis, endometriosis, vaginitis and ureogenital tract infections in women. Serological tests with sensitivities related to specific antigens are commonly used as routine laboratory tests for diagnosis of Chlamydia. In this research the Chlamydia Major O...
[ 5 ] - بررسی تغییر ژن پروتئین M2 ویروس آنفلوانزا H1N1 در بیان آن درباکتری Ecoli سویه BL21
Aim and Background: By Attention to gene sequence and each amino acid codon in host which express protein, also in order to probable vaccine production against influenza A, a major cause of mortality in a year,this research was carried out. M2 protein is conserved and it can be a proper candidate vaccine for influenza infection. Materials and Methods: Present research was an experimental study....
[ 6 ] - مطالعه اثر ادجوانت HSP90 بر ایمنی زایی HbsAg در موش بالب‌سی
Abstract Background: Heat shock proteins, (Hsps) are used as adjuvants in vaccines these proteins induce the inflammatory cytokines and the maturation of monocyte MQ to dendritic cells. This study was done to determine the effect of Hsp90 on the immunogenicity of HbSAg in BalbC mice. Materials and methods: In this experimental study we injected Hsp90 β subunit together with HbsAg to 30 balbC mi...
[ 7 ] - In-vitro Transcribed mRNA Delivery Using PLGA/PEI Nanoparticles into Human Monocyte-derived Dendritic Cells
Induction of protein synthesis by the external delivery of in-vitro transcription-messenger RNA (IVT-mRNA) has been a useful approach in the realm of cell biology, disease treatment, reprogramming of cells, and vaccine design. Therefore, the development of new formulations for protection of mRNA against nucleases is required to maintain its activity in-vivo. It was the aim o...
[ 8 ] - In-vitro Transcribed mRNA Delivery Using PLGA/PEI Nanoparticles into Human Monocyte-derived Dendritic Cells
Induction of protein synthesis by the external delivery of in-vitro transcription-messenger RNA (IVT-mRNA) has been a useful approach in the realm of cell biology, disease treatment, reprogramming of cells, and vaccine design. Therefore, the development of new formulations for protection of mRNA against nucleases is required to maintain its activity in-vivo. It was the aim o...
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