Mohammad-Reza Zarrindast
5. Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - Anxiolytic-like Effects and Increase in Locomotor Activity Induced by Infusions of NMDA into the Ventral Hippocampus in Rat: Interaction with GABAergic System
Introduction: In this study, we investigated the role of N-Methyl-D-Aspartate (NMDA) receptors in the ventral hippocampus (VH) and their possible interactions with GABAA system on anxiety-like behaviors. Methods: We used an elevated-plus maze test (EPM) to assess anxiety-like behaviors and locomotor activity in male Wistar rats. Results: The results showed that intra-VH infusions of diffe...
[ 2 ] - Executive functions are related to serum testosterone and basal metabolism rate fluctuation but not lymphocyte dopamine receptor expression in the young healthy participants
Introduction: Herein, we evaluated linkages between EFs performances and dopamine receptor (DR) mRNA and testosterone level in the young Iranian male people. Methods: All 140 participants were normalized using depression, anxiety and stress scale questionnaire. Remained 108 volunteers were tested against drug abuse and then volunteers were distinguished by Wisconsin Card Sorting Test (WSC...
[ 3 ] - Transient inactivation of the central amygdala modulates metabolic and hormonal responses to acute stress in female rats
Introduction: Current study examined the possible role of the central nucleus of amygdala (CeA) transient inactivation on the metabolic and hormonal disturbances induced by acute electro foot shock stress in female rats. Considering the differences between female and male in responses to stress, this study attempts to reveal possible mechanisms underlying these differences. Methods: Uni- or bil...
[ 4 ] - Role of L-NAME, a nitric oxide synthase inhibitor, in the improvement of morphine-induced amnesia induced by nicotine
Introduction: Drugs of abuse such as nicotine and morphine used systemically by addicts produce their effects via the mesolimbic dopaminergic pathway. Furthermore, evidence indicates that some behavioral effects of nicotine and morphine are mediated by nitric oxide (NO). Based on these observations, the aim of the present study was to investigate the effects of intra-nucleus accumbens (NAc) ...
[ 5 ] - Involvement of central amygdala muscarinic receptors in morphine-induced amnesia in rat
Introduction: Learning and memory processes result from interaction of neurotransmitter systems in various brain regions such as amygdala and hippocampus. Considering that morphine induces memory impairment, in the current study, we examined the possible role of cholinergic muscarinic receptors of the central amygdala (CeA) on the morphine-induced amnesia in adult male Wistar rats. Methods...
[ 6 ] - بررسی نقش گیرنده سروتونرژیک 5HT4 ناحیه CA3 هیپوکمپ شکمی بر حافظه هیجانی موش های صحرایی در مدل ماز بعلاوه شکل مرتفع
زمینه مطالعه: شواهد زیادی وجود دارد که نشان می دهد گیرنده های سروتونرژیک هیپوکمپ نقش بسیار مهمی در شکل گیری حافظه هیجانی دارند، لذا لازم است نقش تمامی گیرنده های سروتونرژیک هیپوکمپ در شکل گیری حافظه هیجانی به صورت مجزا و با استفاده از مدل های رفتاری مختلف مورد مطالعه و بررسی قرار گیرد. هدف: هدف از انجام این مطالعه بررسی نقش گیرنده سروتونرژیک 5HT4 ناحیه CA3 هیپوکمپ شکمی بر حافظه هیجانی موش های ص...
[ 7 ] - اثر سیستم گابانرژیک و گیرنده CB1 کانابینوییدی هسته قاعده‌ای- جانبی آمیگدال بر فراموشی و رفتارهای شبه اضطرابی در مدل ماز در موش سوری نر
Background: As a psychoactive plant, Cannabis sativa (Marijuana) is widely used throughout the world. Several investigations have indicated that administration of Marijuana affects various cognitive and non-cognitive behaviors. These include anxiety-like behaviors and learning and memory deficit. It has been shown that three main cannabinoid receptors [i.e. CB1, CB2 and CB3 are involved in cann...
[ 8 ] - اثر تنظیمی آگونیست گیرنده 5-HT4 بر حافظه ترس در هیپوکامپ پشتی موش کوچک آزمایشگاهی
مقدمه: RS67333 آگونیست انتخابی گیرنده 4 سیستم سروتونرژیک(5-HT4) و ACPA (Arachidonylcyclopropylamide) آگونیست انتخابی گیرنده 1 سیستم کانابینرژیک(CB1) می باشد. هدف از این پژوهش بررسی اثر تزریق دو طرفه RS67333 در هیپوکامپ پشتی(CA1)، بر فرایند تشکیل حافظه ترس القاء شده توسط ACPA در موش های کوچک آزمایشگاهی نر بالغ بوده است. مواد و روش ها: 120 سر موش کوچک آزمایشگاهی نر نژاد NMRI در محدوده وزنی...
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