شریف رازی, مریم
سازمان انتقال خون
[ 1 ] - اثر فرایند کاهش لکوسیتی پیش از ذخیره بر سطوح بیان مولکول پیش التهابی CD40L در فرآورده‌های پلاکت رندوم حاصله از PRP
Background: Several lines of evidence suggest the role of leukocyte in platelet activation. Since pro-inflammatory mediator CD40 ligand (CD40L) has been considered as a marker of platelet activation that reflecting platelet storage lesion (PSL), we evaluated the effect of leukoreduction processes on thereby the levels of expressed CD40L in Platelet Concentrates (PCs). Methods: In present stu...
[ 2 ] - تولید گونه‌های اکسیژن واکنشگر به‌عنوان شاخص فعالیت پلاکتی در فرآورده‌های پلاکتی تغلیظ شده از پلاسمای غنی از پلاکت: گزارش کوتاه
Background: Platelet storage is complicated by deleterious changes that cause progressive structural and functional damages, so-called platelet storage lesion (PSL). PSL is commonly manifested by augmented platelet activation which is also associated with the increased levels of reactive oxygen species (ROS). Whether ROS generation increases during the storage of platelet concentrates and wheth...
[ 3 ] - پلی‌مورفیسم مولکول HLA-E در بیماران تالاسمی در ایران
Background: Human leukocyte antigen E is a member of non-classical HLA class I. Interaction between HLA-E molecule on the target cells and inhibitory CD94/NKG2A receptor on the cell surface of natural killer (NK) cells has an important role in the regulation of immune system against pathogens; therefore different cell surface expression of HLA-E molecule plays an important role in host resistan...
[ 4 ] - مطالعه سطوح بیان گیرنده‌های چسبندگی پلاکتی در فراورده‌های پلاکتی تغلیظ شده از پلاسمای غنی از پلاکت
Background: Major platelet adhesive receptors that contribute significantly to thrombus formation include platelet receptor glycoprotein Ibα (GPIbα) of the GPIb-IX-V complex and platelet glycoprotein VI (GPVI). GPIbα plays a crucial role in platelet tethering to sub-endothelial matrix, which initiates thrombus formation at arterial shear rates, whereas GPVI is critically involved in platelets f...
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