M Gallus

[ 1 ] - P 45: De- and Remyelination Affect Cognitive and Locomotor Abilities in Mice

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by inflammatory and neurodegenerative processes. One of its pathophysiological hallmarks is demyelination, a consequence of oligodendroglial cell death leading supply shortfall and missing electrical insulation to axons. Demyelination induced consequences on neuronal network activity and subsequen...