Johannes Greiff

[ 1 ] - P 44: The Role of HCN Channels in T Cell Function

Ion channels play a major role in the regulation of T cell function in health and disease. In a computer-based model, established to simulate T cells’ membrane potential (VM) generation, we discovered a discrepancy between the simulation and patch-clamp recordings. The predicted VM was more hyperpolarized than the measured VM, indicating that a yet unknown, depolarizing ion current might ...