Abdolreza Esmaeilzadeh
Cancer Gene Therapy Research Center (CGRC), Zanjan University of Medical Sciences, Zanjan, Iran
[ 1 ] - P106: Interleukin-1 Beta; A Forgotten Piece of MS Puzzle Target Therapy
Multiple sclerosis (MS) is an inflammatory autoimmune disease which is presented by environmental factors and genetic predisposition, increasingly affecting a large number of people worldwide. CNS inflammation is a local tissue response to stimulants and is characterized by induction of cytokines, chemokines and vascular permeability. Our goal in this study is to understand the micro-environmen...
[ 2 ] - P107: Using Nano Particles as a Novel Application for Alzheimer’s Disease; an Effective Endeavor for Drug Delivery
As the most common cause of dementia among the elderly results in cognitive and ‎behavioral impairment, Alzheimer’s disease (AD) is characterized with aggregation of senile ‎plaques (Beta-amyloid protein), cortical atrophy and ventricular enlargement. Unfortunately, ‎conventional methods like acetyl cholinesterase inhibitor drugs, are not so effective owing to ‎restrictive...
[ 3 ] - P140: The Roles of Micro RNA in Multiple Sclerosis Disease
As one of the most common neurological disabilities in young adults, Multiple sclerosis (MS) has characteristics of inflammation, demyelination, neuro-axonal damage, and progressive prolonged disability. The disease is clinically divided into three general categories according to response to treatment: Relapsing-Remitting MS (RRMS), Primary Progressive MS (PPMS) and Secondary Progressive MS (SP...
[ 4 ] - .بیومارکرهای سپسیس؛ رویکردی تازه در تشخیص و پیگیری درمان بیماری های عفونی
سابقه و هدف: سپسیس، پاسخ التهابی سیستمیک میزبان به عفونت، پس از تهاجم پاتوژن های میکروبی به جریان خون است که به دنبال خود، سرکوب ایمنی منجر شونده به عدم عملکرد چندین ارگان و حساسیت به عفونت های بیمارستانی را در پی دارد. پاتوژنز سپسیس پیچیده است و مکانیسم آن هنوز به طور کامل شفاف سازی نشده است. علاوه بر آن، پیچیدگی تظاهرات بالینی، بروز مقاومت آنتی بیوتیکی و نهایتا ازمان بیماری، محققان را به سمت ...
[ 5 ] - Association of ENPP1 (K121Q rs 1044498) and TCF7L2 (C/T rs7903146) Gene Polymorphisms with Type2 Diabetes in Zanjan population (Northwest, Iran)
Background and Objective: Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a class II membrane glycoprotein that binds to insulin α receptor and can interfere in insulin signaling pathway. Transcription factor-7-like 2 (TCF7L2) is a transcription factor which plays a critical role in pancreatic β cell activity. ENPP1 and TCF7L2 gene polymorphisms may have functional role in suscep...
[ 6 ] - Personalized Immunology in Cancer: Paving the Way Towards a Better Quality of Life
Conventionally, in specific diseases, patients receive similar therapies; relying on a "one size fits all" approach. The discovery of P5 (Predictive, Preventive, Personalized, Participatory, and psycho-cognitive) improves personalized diagnosis, treatment, and prognosis. Considering the high prevalence, mortality rate, and complexity of cancers, there is a critical necessity to choose specific ...
[ 7 ] - Personalized Immunology in Cancer: Paving the Way Towards a Better Quality of Life
Conventionally, in specific diseases, patients receive similar therapies; relying on a "one size fits all" approach. The discovery of P5 (Predictive, Preventive, Personalized, Participatory, and psycho-cognitive) improves personalized diagnosis, treatment, and prognosis. Considering the high prevalence, mortality rate, and complexity of cancers, there is a critical necessity to choose specific ...
[ 8 ] - Induction of Immunogenic Response in BALB/c Mice by Live and Killed Form of Recombinant Lactococcus lactis Displaying EG95 of Echinococcus granulosus Immunogenic Response in BALB/c Mice
Background: CE is a zoonotic parasitic infection caused by Echinococcus granulosus worldwide and is associated with economic losses among livestock animals. EG95 is an immunogenic antigen from the E. granulosus. Lactococcus lactis has been prested as a safe vehicle for antigen delivery. The goal of this study was to design a novel L. lactis strain displaying EG95 as a vaccine delivery system. M...
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