Mohammad Mohammadzadeh
Physiology Department, Mashhad University of Medical Sciences, Mashhad, Iran
[ 1 ] - P2: The Role of Neuronal Nitric Oxide Synthase on the Anti-Seizure Effects of 5-HT1A Receptors in Perforant Pathway Kindling Model in Rat
Neuronal nitric oxide synthase (nNOS) plays a role in synaptic potentiation and kindling process.The relationship between nNOS and 5-HT1A receptors also nearly has been specified. In this research,we investigate the role of nNOS on the anticonvulsant effect of 5-HT1A receptors. 24 male (280 ± 30 g) were randomly assigned to four groups (vehicle,NI,Way 100635 and NI + Way100635) (n = 6). ...
[ 2 ] - Effect of intracerebroventricular administration of ascorbic acid on a seizure model induced by pentylenetetrazol in male rats
Introduction: Epilepsy is one of the most common and chronic neurological disorders. It appears periodically and usually is concomitant with unpredictable seizures due to abnormal discharge of brain neurons. In this study, we investigated the anticonvulsant effect of ascorbic acid (AA) on seizures induced by pentylenetetrazole (PTZ) in male rats. Methods: In this study PTZ (37 mg/kg) was in...
[ 3 ] - The Effect of Hydro-alcoholic Extracts of Anethum graveolens L. (Dill) on Amygdala Kindled in Rats
Background: Although hydro-alcoholic extracts of Anethum graveolens L. had Anticonvulsants effect on PTZ-induced kindling seizure behavior, but on the amygdala kindling in rats induced seizure has not been investigated. Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolens L. on seizures using electrical amygdala kindling model. Methods: ...
[ 4 ] - The Effect of 6-Gingerol on Growth Factors and Apoptosis Indices in Rats Exposed to Gold Nanoparticles
Introduction: Research has shown that gold nanoparticles (AuNPs) can damage the physiological processes of brain tissue. Given the antioxidant properties of gingerol (GING), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), DNA oxidative damage, and the amount of Bax and Bcl2 apoptosis ...
[ 5 ] - The effect of camel milk on pain, anxiety and spatial memory in male offspring of female rat model of autism induced by valproic acid
Background & Aim: Autism is a disorder characterized by anxiety, impairment in memory, and pain. Camel milk has antioxidant, immunomodulatory, and anti-inflammatory properties. This study aimed to determine the effect of camel milk on pain, anxiety, and spatial memory in male offspring of female model rats induced via valproic acid. Methods: In an experimental study, female Wistar rats were in...
[ 6 ] - The effect of sodium valproate on sex hormones in male rats
Background & Aim: Sodium valproate is one of the most common antiepileptic drugs used in the first line of treatment for epilepsy, bipolar disorder, mood disorders, and more recently, as an anticancer drug. The occurrence of seizures and the use of Sodium valproate both have sexual and hormonal side effects and ultimately cause infertility in males. In previous studies, the definitive effects o...
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