Luca Fazio
Department of Neurology and Institute of Translational Neurology, University of Münster, Münster, Germany
[ 1 ] - O3: Pharmacological Modulation of Thalamic KCNQ-Potassium Channels: Insight from Knock-out Mice
The channels belonging to the KCNQ gene family consist of 5 different subtypes, which assemble as pentameric channels. The KCNQ2-5 subunits are highly expressed in the ventrobasal thalamus (VB) where they function primarily as KCNQ2/3 heteromers. They underlie an outward potassium (K+)-current, called M-current (IM), which provides a hyperpolarizing drive, thus regulating neuronal excitability....
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