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[ 1 ] - اثر میدان مغناطیسی با شدت100μT بر جذب استخوان در موش صحرایی
زمینه و هدف: میدان های الکترومغناطیسی در محیط اطراف ما با شدت های متفاوت وجود دارند. به همین دلیل بررسی اثر آنها بر موجود زنده حایز اهمیت است. هدف از انجام این مطالعه بررسی اثر میدان بر روند جذب استخوان و تاثیر متقابل استخوان و هورمون هایی چونPTH و کلسی تونین در اثر میدان بر یکدیگر بود. روش بررسی: در این پژوهش تجربی 30 موش صحرایی نر نژاد Spraague –Dawley به سه گروه تقسیم شدند. حیوانات گروه آزما...
[ 2 ] - Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm
Background: Normal sperm function depends on appropriate intracellular calcium (Cai2+) and reactive oxygen species (ROS) levels. Calcium activates NADPH oxidase-5 (NOX5) that leads to ROS generation. The calcium channel of sperm (CatSper) is activated by progesterone and intracellular alkalization. Herein, the interactive role of CatSper, Hv1 channels, and NOX5 enzyme on Cai2+ and ROS generatio...
[ 3 ] - Comparing Human Sperm Quality Preserved at Two Different Temperatures; Effect of Trolox, Coenzyme Q10 and Extracellular Adenosine Triphosphate
Cooling method was proposed to maintain the sperm quality for several days. Nevertheless, during this procedure, sperm is encountered to “cold shock”, and its quality decreases time-dependently. This study was designed to improve the in vitro sperm preservation methods. Thirty normal semen samples were examined in Shiraz, Iran, 2017. Fifteen samples were incubated at 22-27 °C and 15 samples wer...
[ 4 ] - Inhibition of the CatSper Channel and NOX5 Enzyme Activity Affects the Functions of the Progesterone-Stimulated Human Sperm
Background: Low levels of reactive oxygen species (ROS) and calcium are necessary for sperm function. NADPH oxidase 5 (NOX5) is a membrane enzyme which produces ROS. This enzyme is dependent on calcium for its activity. We investigated the importance of NOX5 and an important calcium channel (CatSper) on sperm function.Methods: This laboratory in-vitro study was done in Shiraz, Iran, 2016. Norma...
[ 5 ] - Combined Effect of Trolox and EDTA on Frozen-Thawed Sperm Quality
The freezing and thawing process not only is associated with serious damage to sperm such as damage to the plasma membrane and the acrosomal membrane but also changes the membrane permeability to some ions including calcium. Also, the generation of oxygen free radicals is increased during the freezing-thawing process. The purpose of this study was to evaluate of the effects of Trolox as an anti...
[ 6 ] - The Effects of EGTA on the Quality of Fresh and Cryopreserved-Thawed Human Spermatozoa
Background: Sperm cryopreservation-thawing process has damaging effects on the structure and function of sperm, namely cryoinjury. Calcium overload has been reported as a postulated mechanism for sperm damage during the first steps after thawing. This study was designed to assess the intracellular calcium (Ca2+i) after cryopreservation and to clarify the role of a calcium chelator ethylene glyc...
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