افضلی, محبوبه
[ 1 ] - بررسی اثر عصاره دی‌کلرومتانی ستاره شکننده گونه خلیج فارس (Ophiocoma erinaceus) در القاء مرگ برنامه‌ریزی شده سلول بر رده سلولی EL4
Background and Objective: The natural products are considered promising candidates for cancer treatment. Brittle stars are echinoderms that biologically include active compounds. The aim of this study was to evaluate the effect of the Persian Gulf brittle star (Ophiocoma erinaceus) dichloromethane extract on induction of apoptosis in the EL4 cell line. Materials and Methods: In this...
[ 2 ] - The synergistic influence of the sea cucumber (Holothuria arenicola) extract and dacarbazine on murine melanoma cancer cells B16F10
Melanoma has been reported a contemporary malignant cancer. Here, anti-cancer effects of sea cucumber extract (SCE) have been examined on melanoma cells and compared with dacarbazine. MTT assay and morphological analysis were performed to evaluate cytotoxic effects of methanolic SCE Also, several methods were exerted to detect cell dying by SCE and dacarbazine. The MTT assay showed that B16F10 ...
[ 3 ] - اثر سیتوتوکسیک عصاره دیواره بدن خیار دریایی گونه (Holothuria arenicola) بر روی سلولهای سرطانی ملانومایی
زمینه و هدف: خیار دریایی در اغلب اکوسیستم های دریایی جزء مهمی از اکوسیستم های آبی به شمار می آید. ملانوما به عنوان خطرناک ترین فرم سرطان پوست، مدتهای مدیدی است که بشر را تحت تاثیر قرار می دهد. در پژوهش حاضر اثر سیتوتوکسیک عصاره دیواره ی بدن خیار دریایی گونه Holothuria arenicolaبر روی سلولهای سرطانی ملانوما بررسی شده است. روش بررسی:در این پژوهش تجربی آزمایشگاهی رده ی سلولی ملانومای موشی در محیط ...
[ 4 ] - The effect of exosomes derived from human ovarian epithelial cancer cells on the secretion of AMH and Inhibin in granulosa cells
Exosomes are secreted by different types of cells and known as biological packages. Exosomes have significant role in intercellular communications and involved in the development and progression of various diseases such as cancer. Inhibin B and anti-mullerian hormone (AMH) are markers of granulosa cell tumors (GCT) and due to the role of exosomes in the progression of cancer, in this experiment...
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