هاشمی سوته , سیدمحمدباقر
[ 1 ] - بررسی فراوانی فاکتور V لیدن (G1691A)، پروترومبین G20210A و تغییر C667T در ژن سازنده آنزیم متیلن تتراهیدروفولات ردوکتاز (MTHFR) در بیماران تالاسمی ماژور و اینترمدیا مراجعه کننده به مرکز تحقیقات تالاسمی در مقایسه با افراد سالم در شمال ایران
Background and purpose: Mutation in factor V Leiden (R506Q), mutation of G20210Â in prothrombin and mutation of Ç667T in methylenetetrahydrofolate reductase (MTFHR) are part of genetic variant that increase the risk of thrombosis. The purpose of this study was to define the frequencies of three risk factors among thalassaemia major and thalassaemia intermedia compared with the normal subjects...
[ 2 ] - فراوانی موتاسیونهای ژن بتا - گلوبین در بیماران بتا-تالاسمی شرق مازندران
Background and purpose: Beta-thalassemia is the most common inherited disorder in the world, especially in Iran. According to Iranian thalassemia society registry, 18616 thalassemia patients now living in Iran, which Mazandaran and Fars provinces have the most patients. Previous reports have shown that the frequency of b-thalassemia carriers is more than 10% in Mazandaran province. Although b...
[ 3 ] - بررسی ارتباط موتاسیون های ژن بتا - گلوبین در بیماران بتا - تالاسمی با پاسخ های درمانی متفاوت به داروی هیدروکسی اوره
Background and Purpose: β-thalassaemia is the most frequent inherited disorder in the world, especially in Iran and Mazandaran Province. It is caused by mulation in β-globin gene on chromosome 11 with more than 150 different mulations causing β-thalassaemia, has been identified in the β-globin gene to date. Hydroxyurea, is one of the drugs used in Thalassemia patient’s treatment, however, it ...
[ 4 ] - شیوع هموگلوبینوپاتی در متقاضیان ازدواج مراجعه کننده به مرکز بهداشت شهرستان بابلسر (88-1385)
زمینه و هدف : حداقل 2/5 درصد از جمعیت دنیا ناقل یک نقص عمده هموگلوبین هستند. این مطالعه به منظور تعیین شیوع هموگلوبینوپاتی‌های مختلف متقاضیان ازدواج در مراجعین به مرکز بهداشت شهرستان بابلسر طی سال‌های 88-1385 انجام شد. روش بررسی : این مطالعه توصیفی روی 8500 متقاضی ازدواج (4200 زن و 4300 مرد) از شهرستان‌های بابلسر و فریدونکنار مراجعه کننده به مرکز بهداشت شهرستان بابلسر طی سال‌های 88-1385 انجا...
[ 5 ] - Detection of CYP2C18 m1, and m2 Alleles within an Iranian Population (Mazandaran) Using Denaturing High-Performance Liquid Chromatography (DHPLC)
Background: Genetic polymorphisms of cytochrome p450 in humans are the main cause of differences in the metabolism. The allele and genotype frequencies of CYP2C19 and CYP2C9 have been studied in some Iranian populations. The aim of present study was to examine the frequencies of CYP2C18m1, and CYP2C18m2, alleles in the Mazandarani ethnic group among Iranian Population. Materials and Methods: I...
[ 6 ] - Frequencies of two CYP2C19 defective alleles (CYP2C19*2, and *3) among Iranian population in Mazandaran Province
Background: Cytochrome P450 2C19 (CYP2C19) is a polymorphically expressed enzyme that shows marked interindividual and interethnic variation. CYP2C19*2 and CYP2C19*3 are the most frequently identified defective alleles in Orientals and Caucasian poor metabolizers (PM). The aim of this study was to investigate the frequencies of CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles and CYP2C19 genotypes in...
[ 7 ] - Hepatotoxicity and ALT/AST Enzymes Activities Change in Therapeutic and Toxic Doses Consumption of Acetaminophen in Rats
Acetaminophen (APAP) poisoning is the most common drug intoxication, which often leads to acute liver failure (ALF). In this study, the effects of different doses of APAP on aminotransferases (AST and ALT) and liver pathological lesions were assessed in young rats. 32 male albino Wistar rats were randomly selected and divided into eight groups. In case groups, three groups after one hour, and 3...
[ 8 ] - Prevalence of IMP and SPM Genes in Clinical Isolatesof Carbapenem Resistant Acinetobacter baumannii in Educational Hospitals of Sari, Iran
Background and purpose: Acinetobacter Baumannii is an opportunistic bacterium, which is considered as a concern in hospitals throughout the world due to high antibiotic resistance rate. The aim of this study was to investigate the prevalence of carbapenem resistance genes in clinical isolates of this bacterium. Materials and methods: In this study, 100 clinical isolates of Acinetobacter Bauman...
[ 9 ] - Genetic Counseling for Families with Sporadic Intellectual Disability in North of Iran: A Retrospective Study
Background Intellectual Disability (ID) is a heterogeneous disorder, in which at least 600 genes participate. The present study aimed to identify the effect of genetic counseling and consanguinity marriage in Iranian families with sporadic mental disability. Materials and Methods: In th...
[ 10 ] - Healthy Generation Components on Acquisition, Application, and Transferring Values to Next Generations According to Islamic Views and Genetics
Background and purpose: Generational health analysis on the acquisition, application, and transfer of intergenerational values is an important issue from the perspective of religion and genetics. Healthy generation means generational solidarity and lack of disruption or crisis in generations despite generational differences. The purpose of this study was to identify the common points and soluti...
نویسندگان همکار