ابراهیم زاده, محمد علی

[ 1 ] - بررسی تاثیر روش استخراج بر محتوای تام فنلی، فلاونوئیدی، فعالیت آنتی اکسیدانی و آنتی هیپوکسی گیاه تره Allium ampeloprasum

Background and purpose: Allium (Liliaceae) genus has about 600 spp. This investigation was designed to study the impact of extraction methods on total phenolic and flavonoid contents, antioxidant, and antihypoxic properties of A. ampeloprasum in mice. Materials and methods: The aerial parts were extracted by three different methods, i.e. maceration, ultrasonic assisted (UAE) and Soxhlet assist...

[ 2 ] - ارزیابی فعالیت آنتی اکسیدانی و محافظت کبدی اندام هوایی گیاه ماشک کلاغی Vicia cracca در مقابل سمیت ناشی از تتراکلرید کربن در کبد موش سوری

Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration meth...

[ 3 ] - تاثیر روش های مختلف استخراج بر فعالیت آنتی اکسیدانی و فعالیت آنتی باکتریال گیاه Nonnea lutea

Background and purpose: No reports are found on biological activities of Nonea lutea (boraginaceae). The aim of this study was to investigate the antioxidant and antibacterial activities of this plant. Materials and methods: The aerial parts were extracted by three different methods, i.e. meceration (MA), ultrasonic assisted (US), and soxhlet assisted (SO) extractions with methanol. Antioxidat...

[ 4 ] - ارزیابی فعالیت آنتی اکسیدانی ماشک معمولی(Vicia hirsuta)، اهمیت روش استخراج

Background and purpose: The genus Vicia (Papilionaceae) contains 45 species in Iran. This investigation was designed to study the impact of extraction methods on total phenolic and flavonoid contents and antioxidant activities of V. hirsuta aerial parts. Materials and methods: In this experimental study the efficiencies of three extraction methods i.e. Maceration, Soxhlet, and ultrasonically a...

[ 5 ] - نانو ذرات آهن صفر ظرفیتی: روش های سنتز، شناسایی و کاربردهای آن در پزشکی و بیولوژی

Magnetic nanomaterials are making significant impact on improving the quality of human health that is tangible from a wide range of applications in various fields of medicine and biology. In recent years, nanoparticles successfully demonstrated outstanding applications due to having excellent magnetic properties of the iron oxide nanoparticles-based counterparts. Zero-valent iron nanoparticles ...

[ 6 ] - مقایسه اهمیت روش های مختلف استخراج بر فعالیت آنتی اکسیدانی برگ گیاه مورد Myrtus communis

Background and purpose: Myrtus communis L. (Myrtle, Myrtaceae) is a known medicinal plant used in traditional medicine worldwide. It is a well-known plant with distinctive antioxidant activity. In this study we investigated the impact of extraction methods on total phenolic and flavonoids contents and antioxidant activities of Myrtle (Myrtus communis L.) leaf. Materials and methods: The shade-...

[ 7 ] - نقش افزایش قطبیت حلال در محتوای تام فنل و فلاونوئیدی و میزان فعالیت آنتی اکسیدانی گیاه مورد Myrtus communis L.

Background and purpose: Medicinal plants are the main source of very potent antioxidants. Myrtus communis L. (Myrtle, Myrtaceae) is a medicinal plant used worldwide in traditional medicine. It is a well-known plant with distinctive antioxidant activity. This study aimed at investigating the effect of solvents extraction on total phenolics and antioxidant activity of extracts from Myrtle (Myrt...

[ 8 ] - آنتی‌اکسیدان‌ها و برخی از روش‌های متداول اندازه گیری آن‌ها، مقاله مروری

The pathology of numerous chronic diseases, such as cardiovascular dysfunctions, atherosclerosis, inflammation, carcinogenesis, drug toxicity, diabetes mellitus, aging and neurodegenerative involves oxidative damage to cellular components. When body cells use oxygen to generate energy, free radicals are created as a consequence of adenosine triphosphate (ATP) production by the mitochondria whic...

[ 9 ] - سنتز ترکیبات جدید دی هیدروپیریمیدین -2-اون با پتانسیل اثر ضد میکروبی و ضد التهابی

Background and purpose: Dihydropyrimidins are bioisoester of dihydropyridine. In addition to blocking of calcium channels, they have antimicrobial, antiviral, antifungal, antiparasital and antiinflammatory activities. Monastrol is an anticancer dihydropyrimidine derivation that inhibits mitosis. Several marine alkaloids with dihydropyrimidine skeletal have been isolated. In this study, sever...

[ 10 ] - سنتز مشتقات هیدرازیدی از ساخارین و بررسی فعالیت شلاته‌ کنندگی آن‌ها

Background and purpose: Zinc (Zn), copper (Cu) and iron (Fe) are essential minerals required for a variety of biomolecules to maintain the normal structure, function, and proliferation of cells. Abnormal metabolism of heavy metals can lead to several chronic pathogenesis. In this study, two new saccharin hydrazide derivatives were synthesized and their chelatory activities were evaluated. Mate...

[ 11 ] - الگوی مصرف آنتی بیوتیک ها در بخش های مختلف بیمارستان امام خمینی (ره) ساری

Background and Purpose: Due to an increase in cases of irrational drug prescription and it's health and economic consequences, evaluation of the rational use of drugs seemed necessary. Among drug groups antibiotics are greatly significant. Materials and Methods: Utilization pattern of antibiotics in different wards of Sari Imam Khomeini teaching hospital in the first half of 2000 and 2005 ...

[ 12 ] - بررسی اثر ضد درد و ضد التهاب عصاره های هگزان؛ اتیل استات و متانلی بخش های مختلف گیاه پلم (Sambucus ebulus)

Background and purpose: In Iranian folk medicine, the leaves and rhizomes of the plant Sambucus ebulus have been used topically for curing painful joint diseases. This study was undertaken to evaluate the anti-inflammatory and antinociceptive efficacy of different parts of Sambucus ebulus in mice and rats. Materials and Methods: Different parts of Sambucus ebulus were collected from Sari. ...

[ 13 ] - بررسی اثر آنتی‌اکسیدانی چهارگونه گیاهی زولنگ، چوچاخ، تلکا و خرمندی در مدل برون تن

[ 14 ] - بررسی فعالیت آنتی اکسیدانی عصاره متانولی برگ و پوست شاخه گیاه Pterocarya fraxinifolia (Lam.) Spach

Pterocarya fraxinifolia (Lam.) Spach از تیره Juglandaceae به‌صورت خودرو در استانهای شمالی ایران می‌روید. به‌رغم فراوانی، اطلاعات بسیار کمی در خصوص این گیاه گزارش شده است. این تحقیق به منظور بررسی اثر آنتی‌اکسیدانی این گیاه انجام شد. برای این منظور، برگها و شاخه‌های این گیاه از منطقه دشت ناز ساری جمع‌آوری شده و عصاره متانولی آنها استخراج شد. سپس این عصاره‌ها در آزمونهای گوناگون بکار رفت. نتایج ن...

[ 15 ] - ارزیابی محتوای تام فنولی و فلاونوئیدی دو گونه از جلبک های سبز به روش اسپکتروفتومتری و کروماتوگرافی مایع با کارایی بالا

جلبکها از جنبه های بسیار زیادی حائز اهمیت می باشند که می توانند کاربردهای متعددی در صنایع دارویی، غذایی، کشاورزی، مصارف پزشکی و همچنین کاربرد در تصفیه فاضلاب داشته باشند. این تحقیق به منظور بررسی محتوای تام فنولی و فلاونوئیدی دو نوع جلبک سبز به روش اسپکتروفتومتری و کروماتوگرافی مایع با کارایی بالا انجام شد. در این تحقیق جلبک Cladophora glomerata از سواحل دریای خزر و مصب رودخانه بابل رود و جلبکS...

[ 16 ] - تاثیر نیکل و اسیدیته بر فعالیت آنتی اکسیدانی، محتوای تام فنولی و فلاونوئیدی جلبک کلادوفورا گلومراتا

غلظت های بالای نیکل به عنوان عاملی تنش زا برای جلبک ها محسوب می شود که می تواند به عنوان یک عامل محدود کننده رشد جلبک ها را تحت تآثیر قرار دهد. سمیت در اثر این فلز همچنین می تواند از طریق تولید رادیکال های آزاد، سبب القا تنش اکسیداتیو در جلبک ها و گیاهان شود. این تحقیق به منظور بررسی اثر غلظت های متفاوت نیکل و pH بر فعالیت آنتی اکسیدانی، محتوای تام فنولی و فلاونوئیدی انجام گرفته است. مقدار محتو...

[ 17 ] - کاربرد نانوذرات در فرمولاسیون اسانس ها

زمینه و هدف: نانوتکنولوژی توانایی کنترل ویژگی های مواد در مقیاس اتمی و مولکولی است. حوزه پزشکی مدرن و داروسازی هم تحت تأثیر این فناوری قرار گرفته است. در این زمینه بیشترین تمرکز تحقیقاتی بر درون گیری ترکیبات فعال دارویی مخصوصاً داروهای سایتوتوکسیک بوده است. اسانس ها ترکیباتی هستند که کاربردهای درمانی و بهداشتی و آرایشی دارند. آن ها مخلوط پیچیده ای از انواع مولکول های فرار آروماتیک و آلیفاتیک هس...

[ 18 ] - اثرات آنتی‌اکسیدانی فنل و فلاونوئید تام پوست درختان افرا (Acer velutinum) و توسکا (Alnus subcordata)

Background and Aim: Plants are a rich source of phenolic compounds as natural antioxidants are important. Antioxidant compounds that prevent the spread of diseases and the destruction of many of the foods they are extracted from the bark of Acer velutinum and Alnus subcordata trees. The purpose of this study the required the use of bark as the source of phenol is the pharmaceutical industry. Ma...

[ 19 ] - Antihypoxic Activities of Allium sativum Flower in Mice

Background and purpose: Imbalance between low oxygen supply and oxygen demands determines organ hypoxia causing oxidative stress and finally lead to cell death. Compounds with antioxidant activity are able to exhibit antihypoxic property. Allium sativum has distinctive antioxidant activities, but to the best of our knowledge, there is no reports on the protective effect of flower of this plant ...

[ 20 ] - Antihypoxic Activities of Sambucus ebulus Leaf and Fruit and Myrtus communis Leaf in Mice

Background and purpose: Hypoxia occurs especially in heart diseases and could lead to death. Compounds with antioxidant activity could display antihypoxic property. Sambucus ebulus (SE) and Myrtus communis (Myrtle) are well known plants with distinctive antioxidant activities. To the best of our knowledge there are no reports on their antihypoxic activities. Materials and methods: Protective e...

[ 21 ] - Antihypoxic Activities of Hibiscus rosa sinensis in Mice

Background and purpose: Imbalance between low oxygen supply and oxygen demand determines organ hypoxia. It occurs especially in heart diseases and ischemia and causes death. Compounds with antioxidant activity could exhibit antihypoxic properties. Hibiscus rosa sinensis has good antioxidant activity, but there is no information about the antihypoxic activities of this plant. This study was desi...

[ 22 ] - Effectiveness of Sambucus ebulus Leaf Extract in Treatment of Cutaneous Leishmaniasis: A Double Blind Clinical Trial

Background and purpose: Cutaneous leishmaniasis is a skin disease manifested as chronic ulcerative skin lesions. Current standard therapies for this disease are associated with some problems such as high cost, numerous side effects, need for injections, and drug resistance. Sambucus ebulus is used in treatment of skin inflammation. This study aimed at investigating the effects of S. ebulus leaf...

[ 23 ] - Comparing the Effect of Different Extraction Methods and the Role of Solvent Polarity on Total Phenolic and Flavonoid Contents and Antioxidant Activities of Ferula persica

Background and purpose: Ferula persica is traditionally used in treatment of diabetes and rheumatism. There is no report on antioxidant activity of this plant. This investigation was designed to study the impact of extraction methods and solvent polarity on phenolic contents and antioxidant activities of F. persica root and aerial parts. Materials and methods: In this experimental research, th...

[ 24 ] - Effect of Gallic Acid on Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Diazinon in Vitro and in Vivo

Background and purpose: Diazinon is an organophosphate insecticide that binds to the acetylcholinesterase enzyme after metabolization causing its inactivation. Galic acid is a polyphenolic compound with nucleophilic properties. The aim of this study was to investigate the effects of gallic acid on reactivation of acetylcholine and butyrylcholinesterase inhibited by diazinon in mice and human se...

[ 25 ] - Antihypoxic Activities of Aerial Parts and Roots of Ferula persica in Mice

 Background and purpose: Hypoxia occurs in ischemia and heart attack, and leads to death. It involves production of reactive oxygen species. Antioxidants exhibit antihypoxic properties. Ferula persica has distinctive antioxidant activities. Nothing is known about the protective effect of this plant against hypoxia-induced lethality in mice. Materials and methods: Protective effects of methanol...