معیری, اردشیر
گروه آناتومی، دانشکده پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران
[ 1 ] - تعیین میزان بهبود لوکوموتور خودبخودی در موش های صحرایی با ضایعه نخاعی مزمن
مقدمه: ضایعه نخاعی(SCI) از جدی ترین بیماری های کلینیکی است که عوارض آن علاوه بر شخص بیمار، دامن گیر خانواده و جامعــه می شود. بعد از آسیب شدید نخاعی، آستروسیت های سیستم عصبی مرکزی با تبدیل به آستروسیت های واکنشی و ایجاد اسکار گلیال مانعی بزرگ برای بازسازی آکسون ها محسوب می شوند. در مطالعات مختلف، یک بهبود لوکوموتور نسبی خودبخودی در حیوانات دارای ضایعه با گذشت زمان و بدون هرگونه مداخله درمان...
[ 2 ] - بررسی تاثیر پیوند سلول های غلاف کننده بویایی بر بهبود عملکرد حرکتی در فاز تاخیری ضایعه نخاعی موش های صحرایی
مقدمه: ضایعه نخاعی منجر به نقص های عملکردی غیر قابل بازگشت در بیماران می شود. پیش آگهی بد این ضایعه انگیزه تحقیق جهت یافتن یک روش درمانی مناسب برای این آسیب مزمن می باشد. سلول درمانی، یکی از مهم ترین روش های درمانی ضایعه نخاعی می باشد و استفاده از سلول های غلاف کننده بویایی(OECs) نتایج امیدوارکننده ای را نشان داده است. لذا هدف از انجام این مطالعه بررسی تاثیر پیوند سلول های غلاف کننده بویایی بر ...
[ 3 ] - Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions
Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...
[ 4 ] - Purity determining of cultured OECs from olfactory mucosa of rats\' pups
Introduction: Cell transplantation is one of the main strategies for spinal cord injury repair. As OECs of the olfactory mucosa can be obtained by simple biopsy in all individuals without affecting their smell sensation, OECs considered as a promising candidate for autologous transplantation in the nervous system injury, especially for spinal cord repair. Thereby in the current study OECs wer...
[ 5 ] - Effect of different concentrations of Aloe vera leave\'s extract on the healing process of rat\'s second degree burn
Introduction: The aim of this work was to evaluate the effects of four different concentrations of Aloe vera extract on healing of second degree burns in male Wistar rats. Materials and methods: By an experimental study 42 male Wistar rats were divided into 7 equal groups. The burn injury was made on the back of all rats, according to standard methods. The burned areas in the group1: were ...
[ 6 ] - Evaluating the effect of exercise and nutrition on bone density in rats
Introduction: The aim of this research was to study the effect of a 6-week supplemented diet on increasing bone density by measuring calcium, phosphorus and bone mineral density (BMD) in male rats. Materials and methods: In this experimental study, 24 Wistar male rats, aged between 15 and 20 days, were selected. The rats were randomly divided into 3 groups: immune system supplement (ISS), ...
[ 7 ] - Effect of maternal anastrozole treatment on ovarian follicle development in neonatal mouse: A morphologic study
Introduction: The origin of neonatal oocyte development is unknown. However, estrogen plays an essential role during development of the female reproductive system. Anastrozole is used as both ovulation stimulating and an anticancer drug. The aim of this study was to evaluate the impact of Anastrozole on follicular development and differentiation in mice. Materials and methods: In the present s...
[ 8 ] - Nandrolone decanoate administration can increase apoptosis in spermatogenesis cell lines in male rats
Introduction: Anabolic – androgenic steroids (AAS) are used at high doses by athletes for improving athletic ability, muscle mass and physical appearance. Unfortunately, the abuse of these agents has been significantly increased. It has been established that exercise and high doses of AAS may influence the hypothalamic-pituitary-gonadal axis, which can in turn affect testicular apoptosis and m...
[ 9 ] - اثر امواج اولتراسوند تشخیصی بر سلول های پورکنژ مخچه در مدل موش صحرایی الکلیک
مقدمه: سونوگرافی یک روش تصویربرداری پزشکی است که برای ارزیابی و بررسی بافت های عمقی بدن مانند طحال، کبد، عضلات، تاندون ها، عروق خونی و ضایعات آن ها پی ریزی شده که در حاملگی نیز کاربرد دارد. سلول های پورکینژ مخچه بزرگ ترین سلول های سیستم عصبی هستند که در طی مراحل رشد و تمایز حساسیت بسیار بالایی به عوامل مختلفی از جمله عوامل محیطی، شیمیایی و ژنتیکی دارند. الکل یکی از متداول ترین و اثرگذارترین...
[ 10 ] - Evaluating Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Intervention Time in Rats
Introduction: The proteoglycans of the extracellular matrix increases in the glial scar during spinal cord injury and significantly affects the inhibition of axonal regeneration. Methods: The results of injury therapies are limited due to the lack of identifying a timely therapeutic intervention. The present study aimed to investigate the glial scar Chondroitin Sulfate (CS) and Dermatan Sulfa...
[ 11 ] - Transdifferentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Dopaminergic Neurons in a Three-Dimensional Culture
Introduction: The induction of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) toward dopaminergic neurons is a major challenge in tissue engineering and experimental and clinical treatments of various neurodegenerative diseases, including Parkinson disease. This study aims to differentiate HUC-MSCs into dopaminergic neuron-like cells. Methods: Following the isolation and charac...
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