عزیزی, منیره
مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی ایلام، ایلام، ایران
[ 1 ] - تعیین میزان بهبود لوکوموتور خودبخودی در موش های صحرایی با ضایعه نخاعی مزمن
مقدمه: ضایعه نخاعی(SCI) از جدی ترین بیماری های کلینیکی است که عوارض آن علاوه بر شخص بیمار، دامن گیر خانواده و جامعــه می شود. بعد از آسیب شدید نخاعی، آستروسیت های سیستم عصبی مرکزی با تبدیل به آستروسیت های واکنشی و ایجاد اسکار گلیال مانعی بزرگ برای بازسازی آکسون ها محسوب می شوند. در مطالعات مختلف، یک بهبود لوکوموتور نسبی خودبخودی در حیوانات دارای ضایعه با گذشت زمان و بدون هرگونه مداخله درمان...
[ 2 ] - بررسی تاثیر پیوند سلول های غلاف کننده بویایی بر بهبود عملکرد حرکتی در فاز تاخیری ضایعه نخاعی موش های صحرایی
مقدمه: ضایعه نخاعی منجر به نقص های عملکردی غیر قابل بازگشت در بیماران می شود. پیش آگهی بد این ضایعه انگیزه تحقیق جهت یافتن یک روش درمانی مناسب برای این آسیب مزمن می باشد. سلول درمانی، یکی از مهم ترین روش های درمانی ضایعه نخاعی می باشد و استفاده از سلول های غلاف کننده بویایی(OECs) نتایج امیدوارکننده ای را نشان داده است. لذا هدف از انجام این مطالعه بررسی تاثیر پیوند سلول های غلاف کننده بویایی بر ...
[ 3 ] - The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province
Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease. Materials and methods: In this study, two...
[ 4 ] - Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions
Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...
[ 5 ] - Effect of olfactory ensheathing cells (OECs) transplantation on functional recovery in acute phase of spinal contused rats
Introduction: Spinal cord injuries (SCI) lead to permanent irreversible functional deficits. Poor prognosis of patients is the motivation of searching a treatment for the chronic injury. Planting stem cells provides us with a promising strategy. In the meanwhile, the use of olfactory ensheathing cells (OECs) has shown very good results. This study aims at evaluating the effe...
[ 6 ] - Purity determining of cultured OECs from olfactory mucosa of rats\' pups
Introduction: Cell transplantation is one of the main strategies for spinal cord injury repair. As OECs of the olfactory mucosa can be obtained by simple biopsy in all individuals without affecting their smell sensation, OECs considered as a promising candidate for autologous transplantation in the nervous system injury, especially for spinal cord repair. Thereby in the current study OECs wer...
[ 7 ] - Effect of different concentrations of Aloe vera leave\'s extract on the healing process of rat\'s second degree burn
Introduction: The aim of this work was to evaluate the effects of four different concentrations of Aloe vera extract on healing of second degree burns in male Wistar rats. Materials and methods: By an experimental study 42 male Wistar rats were divided into 7 equal groups. The burn injury was made on the back of all rats, according to standard methods. The burned areas in the group1: were ...
[ 8 ] - Evaluating Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Intervention Time in Rats
Introduction: The proteoglycans of the extracellular matrix increases in the glial scar during spinal cord injury and significantly affects the inhibition of axonal regeneration. Methods: The results of injury therapies are limited due to the lack of identifying a timely therapeutic intervention. The present study aimed to investigate the glial scar Chondroitin Sulfate (CS) and Dermatan Sulfa...
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