تولائی, مرضیه
گروه زیست فناوری تولید مثل، مرکز تحقیقات پزشکی تولید مثل، پژوهشکده زیست فناوری جهاد دانشگاهی پژوهشگاه رویان، اصفهان، ایران
[ 1 ] - اهمیت اثرات استرس اکسیداتیو بر اسپرم از دیدگاه سلولی
ناباروری، به ویژه در دهه گذشته به عنوان یک مشکل جهانی در حال افزایش است. که تقریبا 10-15 درصد از جمعیت سراسر جهان را تحت تاثیر قرار داده است. منشاء انواع مختلف ناباروری متفاوت است. مطالعات حاکی از آن است که گونه های فعال اکسیژن (ROS) در علل ناباروری، به ویژه ناباروری مردان دخیل هستند. اگرچه ROS برای عملکردهای فیزیولوژیکی از جمله ظرفیت یابی، واکنش آکروزومی و اتصال اسپرم به تخمک ضروری میباشد ولی...
[ 2 ] - استرس اکسیداتیو و اثرات آن در ناباروری مردان: یک مقاله مروری
Background and Objectives: Reactive oxygen species (ROS) are essential for sperm physiological functions including capacitation, acrosome reaction, fertilization, and etc. Sperm cell in comparison with other cells is highly prone to oxidative attack due to high level of membrane unsaturated fatty acids and low volume of cytoplasmic space. Therefore, the aim of this review article was to underst...
[ 3 ] - ارزیابی بیان پروتیین متصل به دُمین WW غلاف خلف آکروزومی در اسپرماتوزوآی مردان نابارور با واریکوسل
Background: Post-acrosomal sheath WW domain binding protein (PAWP) is one of sperm factors related to oocyte activation and is expressed in elongating spermatid. Previously, the effect of high of testicular temperature in infertile men with varicocele on semen quality, sperm DNA damage, expression of genes and proteins were reported. In this study, expression of PAWP at RNA and protein levels, ...
[ 4 ] - تاثیر استرس گرمایی بر روند اسپرماتوژنز
زمینه و هدف: اسپرماتوژنز شامل یک سری از مراحل پیچیده است که در تمایز اسپرماتوگونی ها به اسپرم های بالغ دخالت دارد. روند تکوین اسپرماتوگونی ممکن است تحت تأثیر عوامل مختلف ازجمله: تنش گرمایی قرار گیرد و باعث کاهش کیفیت اسپرم و درنتیجه تأثیر منفی بر روی باروری گردد. به سختی می توان به طور کامل از عوامل افزایش دهنده دمای کیسه بیضه (از شیوه زندگی، شغل، محیط زیست تا شرایط پاتوفیزیولوژیکی) جلوگی...
[ 5 ] - Relationship between Expression of Sperm PAWP Protein with Fertilization Rate in Infertile Men Candidate for ICSI Technique
Backgroundm: Post-acrosomal sheath WW domain binding protein (PAWP) is one of the proteins that is expressed during spermatogenesis process and has several roles in sperm differentiation, fertilization, and early embryonic development. The aim of this study was assessment of the relationship between PAWP expression with fertilization rate in infertile men candidate for intracytoplasmic sperm...
[ 6 ] - The role of Musashi protein in spermatogenesis and male infertility
Background: Inactivation of transcription occurs during two phases of spermatogenesis. First, in spermatocytes entering the primary meiosis and the second in round and elongating spermatids. These stages of inactivated transcription demand extensive regulation of translation. Therefore, presence of the control on gene expression during spermatogenesis seems essential. In the cases that post-tra...
[ 7 ] - Evaluation of comparison of clinical outcome treated oocyte with ionomycin and strontium chloride in infertile couple with previous failed in vitro fertilization
Introduction: Several factors are involved in failed fertilization following intracytoplasmic sperm injection (ICSI), which could be related to sperm, oocyte factors and/or both. Failure in oocyte activation is considered as the most important factor in failed fertilization after ICSI. To overcome this shortcoming, artificial oocyte activation (AOA) after ICSI has been suggested. Commonly, iono...
[ 8 ] - Comparison of the Effect of Alpha Lipoic Acid (ALA) and Beta-Defensin 1 Protein on Human Sperm Motility and Viability in Different Times of Incubation
Background and Objectives: Antioxidant alpha lipoic acid and β-defensin 1 protein may have a positive effect on the quality of sperm parameters. In this study, the effect of sperm incubation with alpha lipoic acid antioxidant and β-defensin 1 protein were assessed on sperm motility and viability at different times. Methods: In this experimental study, routine semen analysis was carried out o...
[ 9 ] - نقش و عملکرد تلومر در تولید مثل
اهداف: تلومر‌ها ساختار‌های حفاظت شده‌ی هتروکروماتینی غیر کد شونده با تکرار‌های شش نوکلئوتیدی غنی از گوانین هستند که در انتهای کروموزوم‌ها قرار دارند. این ساختار در طی تکامل حفظ شده‌اند و عملکرد آن ها به طول ساختار وابسته است. در سلول‌های سوماتیک، طول تلومر در هر بار تقسیم سلولی کاهش می‌یابد. کوتاه شدن بیش از حد طول تلومر باعث توقف در چرخه‌ی سلولی، ناهنجاری در تفکیک شدن کروموزوم‌ها و مرگ سلولی...
[ 10 ] - Comparison of Sperm Telomere Length between Two Sperm Selection Procedures: Density Gradient Centrifugation and Zeta Potential
Background: Telomeres are particular sequences of DNA located at the end of the eukaryotic chromosomes that are essential for genome integrity. Telomere length in spermatozoa differs among males, as well as spermatozoa. Also, decreased telomere length in spermatozoa of infertile men is associated with the reduction of fertility potential and embryo quality. Density gradient centrifugation (DGC)...
[ 11 ] - Micronutrients in Support to The Carbon Cycle Activate Antioxidant Defences and Reduce Sperm DNA Damage in Infertile Men Attending Assisted Reproductive Technology Programs: Clinical Trial Study
Background: Micronutrients in support to the carbon cycle were shown to reduce sperm DNA damage both in animal models and infertile men. Besides supporting DNA methylation, their positive effect may be mediated by an improved performance of the endogenous antioxidant system but this has not yet been proven in clinical settings. The present study aimed at evaluating the effects of micronutrient ...
[ 12 ] - Relationship between Sperm Parameters with Sperm Function Tests in Infertile Men with at Least One Failed Cycle after Intracytoplasmic Sperm Injection Cycle
Objective Imbalance between production of reactive oxygen species (ROS) and total antioxidant capacity in testis, epididymis, and seminal fluid can eventually lead to subfertility and infertility. Abnormal chromatin packaging, and DNA fragmentation is considered as the main underlying causes. In this regard, we aimed to assess relationship between sperm parameters with DNA damage, protamine def...
[ 13 ] - An Overview of The Globozoospermia as A Multigen-ic Identified Syndrome
Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-Golgi network (TGN), acroplaxome and cellular trafficking. This review a...
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