فخار, مهدی
گروه انگل‌شناسی، مرکز تحقیقات بیولوژی سلولی و مولکولی، دانشگاه علوم پزشکی، مازندران، ساری، ایران
[ 1 ] - بررسی مرجع شناخت آموزه‌های دینی در دانشجویان دانشگاه علوم پزشکی مازندران
Background and Purpose: Given the role of religious teachings in the health and education of students as created and qualified workforce, the investigation of the sources of these teachings is a matter of paramount importance. Regarding this, the present study was conducted to investigate the source of religious teachings in students of Mazandaran University of Medical Sciences (MAZUMS), Sari, ...
[ 2 ] - بررسی تاثیر اسانس و نانوامولسیون اسطوخودوس بر تریکوموناس واژینالیس در شرایط برون تنی
سابقه و هدف: تریکوموناس واژینالیس (ت. وازینالیس) عامل تریکومونیازیس است. با توجه به افزایش مقاومت و وجود عوارض جانبی داروها، بررسی اثر ضد تریکومونایی اسانس و نانوامولسیون اسطوخودوس (Lavandula officinalis) بر تریکوموناس واژینالیس در شرایط برونتنی هدف این تحقیق است. مواد و روش ها: اجزای اسانس اسطوخودوس با گاز کروماتوگرافی مشخص شد. برای تعیین اثرات سمیت سلولی، از سلول های ماکروفاژ رده J774.A.1 ...
[ 3 ] - مروری بر دارو های ضد سرطان دارای اثرات ضد لیشمانیایی
Leishmaniasis is a major public health problem, but so far there are no effective commercially available vaccines for this disease. Its control strategy is only reliant on therapy, but currently the drugs available for the treatment of leishmaniasis are also limited and a great concern is the rapid rate of resistance to common drugs. The first step in discovery and development of new drugs is t...
[ 4 ] - بهینه سازی روش کشت آکانتاموبا با استفاده از محیط کشت TYM
Background and purpose: Acanthamoeba species are ubiquitous amphizoic organisms which can cause lethal diseases, such as keratitis and encephalitis in domestic animals and humans. The first stage in studies related to Acanthamoeba is achieving abundant amount of amoebae in culture medium. The aim of this study was to evaluate TYM medium as a rich medium for the diagnosis of Acanthamoeba keratit...
[ 5 ] - اثرات ضد تریکومونایی اسانس و نانو امولسیون گیاه رزماری بر تریکوموناس واژینالیس در شرایط آزمایشگاهی
Background and purpose: There is an increasing rate of drug resistance against trichomoniasis and current drugs used in treatment of this disease have many side effects, therefore, attempts have been made to explore alternative drugs favorably from natural sources. The present study aimed at evaluating the anti-Trichomonas effect of essential oil and that of nano-emulsion of Rosmarinus officina...
[ 6 ] - کاربرد روش های مولکولی در مطالعات اپیدمیولوژی و تاکسونومی عفونت های انگلی
Molecular epidemiology refers to the use of molecular tools in assessing the status of a cycle of a disease in a specific population. Currently, easy, fast, and high performance molecular tools are widely used in identifying parasites in clinical and biological samples. The aim of this study was to review molecular tools for better understanding of parasitic infection in taxonomic and epidemiol...
[ 7 ] - کاربرد آریل‌آزول‌ها و آزول‌های با حلقه جوش خورده در طراحی ترکیبات جدید ضدلیشمانیا
Leishmaniasis is a group of tropical diseases with high worldwide prevalence and difficulty in management. At present, the development of resistance and the increase of co-infected leishmaniasis with AIDS have become a serious public health problem. Thus, designing and discovery of effective and non-toxic drugs for the treatment of this disease is very urgent. Azole derivatives have displayed a...
[ 8 ] - ارزیابی برون تنی اثرات عصاره هیدرو الکلی برگ گیاه سلمه (Chenopodium album) بر رشد تریکوموناس واژینالیس
Background and purpose: Trichomonas vaginalis, is one the most common sexually transmitted diseases (STD) in women. Although metronidazole is the drug of choice for trichomoniasis, but due to its side effects attempts have been made to explore an alternative drug particularly with herbal source. Therefore, this study aimed to determine in vitro activity of hydroalcoholic extracts of Chenopodium...
[ 9 ] - گزارش مواردی از بیماری لیشمانیوز احشایی (کالاآزار) در استان های مازندران و گلستان، شمال ایران
Visceral leishmaniasis (VL) or kala-azar is a parasitic disease caused by Leishmania donovani complex. Evidence suggests that visceral leishmaniasis is prevalent in some areas of Mazandaran and Golestan provinces. This study aimed to investigate the cases and also determining the causative agents of VL in these provinces. In this study, seven VL patients (mean age 1.5 years) admitted to the ped...
[ 10 ] - شناسایی مولکولی گونه های لیشمانیا جدا شده از بیماران مبتلا به لیشمانیوز پوستی در شهرستان پاکدشت، طی سال های 93-88
Background and purpose: Recently, sporadic cases of cutaneous leishmaniasis (CL) has been reported in some parts of Pakdasht district, in southeast of Tehran, Iran. The aim of this study was to determine the prevalence of CL and identification of Leishmania spp in Pakdasht district. Materials and methods: We conducted a cross-sectional study in suspected individuals of CL attending Pakdasht ...
[ 11 ] - کاربرد های فناوری نانوسکوپی در عفونت های تک یاخته ای
Identification of materials at the nanometer scale using microscope tools or nanoscopy helps in better understanding of cell physiology. It is one of the available methods in evaluating the changes caused by physico-chemical agents. In recent years, nanoscopic tools have developed greatly in ultrastructural studies or diagnostic purposes and drug screening for human protozoan infections includi...
[ 12 ] - روش های رایج و نوین تشخیص آزمایشگاهی و شناسایی عوامل لیشمانیوز پوستی
Cutaneous leishmaniasis (CL) annually imposes high socio-economic burdens on societies. Although among diagnostic methods, microscopic and or culture methods are considered as golden standard due to their high specificity, but their sensitivities are variable. Today, present microscopic method is considered as the most valid and available method for diagnosis of CL. However, different methods w...
[ 13 ] - بررسی میزان غلظت فلزات سنگین در بافت‌های مختلف ماهی کلیکا و سه خاره دریای خزر
Background and purpose: Heavy metals are released to the environment as a result of industrial, urban and agricultural sewages. They are usually resistant to chemical dissociation. They can easily contaminate aquatic animals especially fishes which are amongst the food chains of human. This study evaluated the concentration of heavy metals in the tissues of different types of Clupeonella cultri...
[ 14 ] - مروری بر روش های مختلف تشخیصی بیماری بابزیوز
Babesiosis is one of the most important parasitic infectious diseases in livestock industry throughout the world. Studies with various diagnosis methods have been done on this disease, nevertheless the current status of using the diagnosis methods with high specificity and sensitivity is not well defined. Hence, this narrative review investigated the published articles on the status of Babes...
[ 15 ] - روند بروز لیشمانیوز پوستی نوع روستایی در شهرستان گنبد کاووس استان گلستان
Background and purpose: Recently, incidence of cutaneous leishmaniasis (CL) has been increased. The present study aimed to investigate the incidence trend of CL in Gonbad-e-Qabus, (Golestan, Iran). Materials and methods: This descriptive study was carried out for patients referring to health center of Gonbad-e-Qabus, during 2009 to 2012. Early diagnosis of CL was carried out by direct smear an...
[ 16 ] - بررسی اپیدمیولوژیک لیشمانیوز پوستی با عامل لیشمانیا تروپیکا در یک کانون جدید ازاستان خراسان رضوی
Background and purpose: Recently, a high rate of cutaneous leishmaniasis (CL) has been reported in Torbat-e-Jam a town in Khorasan Razavi province, Iran. The aim of the present study was to investigate the epidemiological aspects of CL in this district. Materials and methods: This descriptive cross-sectional study was carried out in patients referring to health centers of Torbat-e-Jam, during ...
[ 17 ] - ارزیابی روش های مختلف استخراج DNA از کیست ژیاردیا لامبلیا
Background and purpose: Giardia lamblia (G.lamblia) is one of flagellated protozoan pathogens. Giardiasis is the most common human parasite infection in the world, causing a lengthy course of diarrhea. The aim of the present study was to compare five different methods of DNA extraction from G.Lamblia cyst and determining the most efficient DNA extraction method. Materials and methods: This stu...
[ 18 ] - مقایسه روش تشخیصی MRU و CT scan شکم و لگن در تشخیص علل و سطح انسداد مجاری ادراری بیماران مبتلا به درد حاد پهلو
Background and purpose: Many emergency referrals are due to renal colic which is more frequently caused by nephrolithiasis. Imaging techniques have a key role in diagnosis and treatment of this disease. There are some limitations associated with these techniques, so this study aimed at comparing the diagnostic value of CTU and MRU for the diagnosis of the obstructions of urinary tract. Materia...
[ 19 ] - شیوع سرمی عفونت توکسوپلاسماگوندی در کودکان مناطق روستایی مراوه تپه، استان گلستان
Background and purpose: Toxoplasma is one of the most common infections among humans and animals. The prevalence of Toxoplasma infection is different in regions according to geographical conditions, habits and history of contact with cats. The present study aims to determine the seroepidemiology of toxoplasma in among children in rural areas of Maraveh- tapeh in Golestan province. Materials ...
[ 20 ] - شناسایی و تعیین گونه عامل لیشمانیوز پوستی با استفاده از روش PCR اختصاصی
Background and purpose: Golestan Province is one of the endemic foci of cutaneous leishmaniasis (CL). This study aimed at assessing specific-PCR on Giemsa's stained slides for diagnosis of CL as well as detecting the species of Leishmania parasite in the patients referring to health center laboratory of Gonbad-e-Qabus. Materials and methods: This cross-sectional study was carried out in 2010. ...
[ 21 ] - کاربرد سیستم های برتر آنزیمی برای تعیین هویت عوامل ایجاد کننده لیشمانیوز احشایی (کالاآزار) در ایران با استفاده از روش الکتروفورز ایزوآنزیم
Background and purpose: Visceral leishmaniasis (Kala-azar) is one of the parasitic zoonotic diseases which is caused by Leishmania donovani complex parasites. Thus, the aim of this study is the application of different enzymatic systems for discrimination species and strains visceral leishmaniasis agent. Materials and methods: In this experimental study, reference strains of Leishmania infat...
[ 22 ] - عفونت استرونژیلوئیدس استرکورالیس : عفونت انگلی فراموش شده در بیماران مبتلا به سرطان
مقدمه: بیماران مبتلا به سرطان، مستعد ابتلا به عفونت‌های شدید انگلی به ویژه عفونت استرونژیلوئیدس استرکورالیس هستند. در این راستا، مطالعه حاضر با هدف تعیین میزان فراوانی عفونت‌های انگلی با تاکید بر استرونژیلوئیدس استرکورالیس روی 139 بیمار مبتلا به انواع سرطان، بستری در بخش انکولوژی بیمارستان امام خمینی شهر ساری انجام شد. روش کار: در این مطالعه از نوع توصیفی - مقطعی، نمونه های مدفوع 139 بیمار مبتل...
[ 23 ] - شناسایی گونه های انگل لیشمانیای جدا شده از بیماران مبتلا به کالاآزار به روش واکنش زنجیره‌ای پلی مراز یک مرحله ای
مقدمه: لیشمانیوز احشایی (کالاآزار) بیماری انگلی مهمی است که توسط گونه‌های لیشمانیای دونوانی و اینفانتوم ایجاد می شود. شواهد اپیدمیولوژی نشان می دهد که لیشمانیوز احشایی در بعضی از مناطق شهرستان جهرم از استان فارس شایع است. مطالعه حاضر با هدف تعیین هویت عامل ایجاد کننده لیشمانیوز احشایی در این شهرستان انجام شد. روش کار: در این مطالعه تجربی از 16 نفر بیمار مبتلا به کالاآزار بستری شده در بیمارستان ...
[ 24 ] - تحلیل خوشه‌های موضوعی و ترسیم نقشه‌های علمی پژوهشگران ایرانی حوزه انگل شناسی با تأکید بر شاخص‌های هم تألیفی و شاخص اچ
زمینه و اهداف: استفاده از روش‌های علم سنجی به منظور شناسایی پژوهشگران برتر در حوزه‌های مختلف از یک طرف، و ترسیم نقشه‌های علمی مربوط به رشته‌های خاص از طرف دیگر در سطح بین المللی رواج بسیاری یافته است. لذا هدف مطالعه حاضر ، شناسایی پژوهشگران برتر حوزه انگل شناسی با توجه به شاخص‌های ترکیبی و همچنین شاخص‌های مربوط به انواع مرکزیت بود. مواد و روش کار: این تحقیق از نوع مطالعات علم‌سنجی به شمار می...
[ 25 ] - ﻣﺮوری ﺑﺮوﺿﻌﯿﺖ ﮐﻨﻮﻧﯽ ﺑﯿﻤﺎرﯾﻬﺎی ﺑﺎﺑﺰﯾﻮز و ﺗﯿﻠﺮﯾﻮز و ﭘﺮاﮐﻨﺪﮔﯽ ﮐﻨﻪ ﻫﺎی ﻧﺎﻗﻞ آﻧﻬﺎ در اﯾﺮان
زﻣﯿﻨﻪ و اﻫﺪاف: ﺗﯿﻠﺮﯾﻮز و ﺑﺎﺑﺰﯾﻮز دو ﺑﯿﻤﺎری اﻧﮕﻠﯽ ﻣﻬﻢ در ﺳﻄﺢ اﯾﺮان و دﻧﯿﺎ ﺑﻮده و ﻣﯽ ﺗﻮاﻧﻨﺪ ﺧﺴﺎرات اﻗﺘﺼﺎدی ﻓﺮاواﻧﯽ ﺑﻪ ﺻﻨﻌﺖ داﻣﭙﺮوی وارد آورﻧﺪ. ﻋﻠﯿﺮﻏﻢ آﻧﮑﻪ ﺗﺎ ﮐﻨﻮن ﻣﻄﺎﻟﻌﺎ ت ﺑﺴﯿﺎر ﻓﺮاوان و ﭘﺮاﮐﻨﺪه ای ﺗﻮﺳﻂ ﻣﺤﻘﻘﯿﻦ اﯾﺮاﻧﯽ در ﻣﻮرد اﯾﻦ دو ﺑﯿﻤﺎری و ﻧﺎﻗﻠﯿﻦ آﻧﻬﺎ در ﮐﺸﻮر اﻧﺠﺎم ﺷﺪه اﺳﺖ اﻣﺎ وﺿﻌﯿﺖ ﮐﻨﻮﻧﯽ اﻧﻬﺎ ﺑﻄﻮر دﻗﯿﻖ روﺷﻦ ﻧﯿﺴﺖ ﻟﺬا ﻫﺪف از اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺮرﺳﯽ ﻣﻘﺎﻻﺗﯽ اﺳﺖ ﮐﻪ ﺗﺎﮐﻨﻮن در ارﺗﺒﺎط ﺑﺎ ﺑﺎﺑﺰﯾﻮز و ﺗﯿ...
[ 26 ] - باکتری ها و کرم های مفید: کاندیدهای امید بخش در درمان بیماری های التهابی روده
The gastrointestinal system harbors various microorganisms, known as gut microbiota. Increase in prevalence of inflammatory bowel disease (IBD) in developed countries is associated with changes in the environment, such as decrease in incidence of parasitic infections, especially helminths, and changes in the intestinal flora. Probiotics are useful microbiota for human health. The parasitic worm...
[ 27 ] - Helminthic Parasites as Heavy Metal Bioindicators in Aquatic Ecosystems
Abstract Heavy metals have raised one of the most important problems in ecology and organisms life especially human being and animals. A variety of indicators including tissues of fish, birds and sediment have been used recently to measure the aquatic pollution with heavy metals. The aim of this study was to search the published articles in Iran a...
[ 28 ] - Parasitic Contamination of Consumed Vegetables in Golestan Province, 2012
Abstract Background and Objective: The Outbreak of human parasitic diseases associated with the consumption of raw vegetables often occurs in both developing and developed countries. This study aimed to evaluate parasitic contamination of edible vegetables in Golestan Province. Material and Methods: This cross-sectional study was carried out in the cities of Golestan Province for six months, 20...
[ 29 ] - Prevalence of Cercarial Dermatitis among Paddy-Field Workers in Central Areas of Mazandaran Province
Abstract Background and Objective: Cercarial dermatitis (CD) or swimmer’s itch is a severe inflammatory reaction caused by penetration of the skin by avian and herbivorous schistosomes, esp genus Trichobilharzia. Since both intermediate and final host of this parasite exist in North of Iran, we aimed at determining the prevalence of cercarial dermatitis among paddy-field workers in Central a...
[ 30 ] - An Overview of theLaboratory Diagnostic Procedures of Visceral Leishmaniasis (Kala-Azar)
Abstract Visceral leishmaniasis (Kala-azar) is a systemic infection disease that can be diagnosed by some invasive procedures such as splenic, liver biopsy or bone marrow aspiration, whichare determined as the gold standards for diagnosing of this disease. At present, a variety of noninvasive tests having different specificities and sensitivities are available for the diagnosis of visceral ...
[ 31 ] - Molecular identification of ovine Babesia spp. in north of Iran
Background: Babesia is blood-tissue parasite, which are transmitted by hard ticks from Ixodidae family. The parasite is the cause of Babesiosis among ruminants. Babesia is as one of main fatal factors among livestock in endemic regions such as Iran. The aim of this study was to investigate Babesia spp infection using microscopic and molecular methods among small ruminants in Mazandaran and Gole...
[ 32 ] - Apoptosis as a Potential Target in Therapeutic and Vaccine Interventions against Parasitic Diseases
Apoptosis is a physiological cell death that occurs under normal conditions in major biological processes, including the removal of old, damaged, extra, or harmful cells. It plays an important role in natural evolution, tissue homeostasis, removal of cells damaged or infected by viruses, and removal of immune cells activated against self-antigens. The purpose of this review was to examine the r...
[ 33 ] - A Mini-Review on Iron Chelating Agents as a Promising Therapeutic Target in Treatment of Leishmaniasis
There is a high prevalence of infections caused by Leishmania parasites and increasing rate of drug resistance. Lack of successful treatment with existing drugs calls for new therapeutic approaches. The main strategy in treatment of leishmaniasis is creating apoptosis and eliminating different forms of the parasite. So far, numerous drugs with specific mechanisms including 14-α-demethylase enzy...
[ 34 ] - Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis
Leishmaniasis is a vector-borne zoonotic disease caused by various species of the genus Leishmania, (trypanosomatidae family) that is transmitted by phlebotomine sandflies. The disease can present in a range of clinical forms, including dermal lesions, metastasis mucocutaneous forms, and fatal visceral forms. In this non-systematic review, we aimed at introducing the role of kinetoplast DNA (kD...
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