Xianqin Wang
Analytical and Testing Center of Wenzhou Medical College, Wenzhou 325000, China.
[ 1 ] - Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion
A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was to aim on the influence of bupropion on rat cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutam...
[ 2 ] - Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion
A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was to aim on the influence of bupropion on rat cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutam...
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