Nooshin Azari
Biochemistry Department, Basic Sciences, Fars Science& Research Branch, Islamic Azad University, Shiraz, Islamic Republic of Iran
[ 1 ] - Mechanistic prospective for human PrPC conversion to PrPSc: Molecular dynamic insights
PrPC conversion to PrPSc isoform is the main known cause for prion diseases including Crutzfeldt-Jakob, Gerstmann-Sträussler-Sheinker syndrome and fatal familial insomnia in human. The precise mechanism underling this conversion is yet to be well understood. In the present work, using the coordinate file of PrPC (available on the Protein Data Bank) as a starting structure, separate molecular d...
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