Mehrnaz Keyhanfar

[ 1 ] - Biotic elicitation for scopolamine production by hairy root cultures of Datura metel

The (-)-hyoscyamine, atropine and scopolamine (hyoscine) are three valuable tropane alkaloids while scopolamine is the most important member of this group for the pharmaceutical industry due to its higher demand compared to hyoscyamine and atropine. Scopolamine is an anticholinergic reagent with several therapeutic applications. In the current study, the hairy roots culture of Daturametel was u...

[ 2 ] - In silico prediction of B cell epitopes of the extracellular domain of insulin-like growth factor-1 receptor

The insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor with tyrosine kinase activity. The receptor plays a critical role in cancer. Using monoclonal antibodies (MAbs) against the IGF-1R, typically blocks ligand binding and enhances down-regulation of the cell-surface IGF-1R. Some MAbs such as cixutumumab are under clinical trial investigation. Targeting multiple distinct...

[ 3 ] - اثر منابع کربنی و نیتروژنی بر روی پروفایل اسیدهای چرب قارچ مورتیرلا وینشیا

مقدمه: لیپید میکروبی به علت خواص درمانی اسیدهای چرب، توجه پژوهشگران را به طور گسترده‌ای جلب کرده است. هدف این مطالعه تولید و بهینه‌سازی لیپیدها و اسیدهای چرب توسط قارچ مورتیرلا وینشیا، با استفاده از محیط‌های کشت مختلف بود تا اسیدهای چرب با ارزش برای استفاده در صنایع غذایی و دارویی به دست آید. مواد و روش‏‏ها: قارچ مورتیرلا وینشیا روی محیط کشت پوتیتو دکستروز آگار کشت داده شد. سپس اسپورها به محیط ...

[ 4 ] - Investigating the antibacterial effects of some Lactobacillus, Bifidobacterium and acetobacter strains killed by different methods on Streptococcus mutans and Escherichia coli

Although there are many health advantages assigned to different live bacteria such as probiotics, some health threatening effects have also been reported. For example, live bacteria can transfer antibiotic resistance genes to other commensal and opportunistic bacteria of gastrointestinal tract. Recently, it was shown that using killed bacteria have some advantages over live ones. In this resear...

[ 5 ] - Production and partial purification of thermostable bacteriocins from Bacillus pumilus ZED17 and DFAR8 strains with antifungal activity

The bacteria which are members of the genus Bacillus are known to produce a wide variety of antimicrobial substances and bacteriocins. The main objective of this study was to investigate the effect of these bacteriocins on eukaryotic cells such as fungi, yeast and plant seeds. Several strains were screened for antifungal activities and identified by the means of polymerase chai...

[ 6 ] - Production and partial purification of thermostable bacteriocins from Bacillus pumilus ZED17 and DFAR8 strains with antifungal activity

The bacteria which are members of the genus Bacillus are known to produce a wide variety of antimicrobial substances and bacteriocins. The main objective of this study was to investigate the effect of these bacteriocins on eukaryotic cells such as fungi, yeast and plant seeds. Several strains were screened for antifungal activities and identified by the means of polymerase chain reacti...

[ 7 ] - The role of plant antioxidants in the synthesis of metal nanoparticles

In recent years, the number of reports of nanoparticle production using green methods has increased exponentially. Green methods of nanoparticle production are based on oxidation and reduction reactions in which metal ions are reduced to nanoparticles with the help of compounds in living organisms or their extracts, including antioxidants. The presence of biomolecules, including antioxidants in...