Farajollah Mohanazadeh

[ 1 ] - A new method for the preparation of pure topiramate with a micron particle size

Crude topiramate was prepared from the reaction between diacetonefructopyranose, sulfuric diamide, and 2-picoline. During a controlled processing the presence of Triton-X-100, crude topiramate in a methanol-water solvent, was converted to pure micron size topiramate particles. The factors affecting the purification and micronization of topiramate, such as solvent and anti-solvent type and conce...