Fatemeh Hajghasemi
Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran.
[ 1 ] - Profile of interleukin-2 production in human mononuclear cells and T-cell lines
Introduction: Interleukin-2 (IL-2) as a T helper type 1 (Th1) cytokine has an important role Background and Objective: Interleukin-2 (IL-2) as a T helper type 1 (Th1) cytokine has an important role in activation, growth and differentiation of several immune cells. Moreover IL-2 is known as a pro-inflammatory and anti-tumoral cytokine. In addition deysregulation of IL-2 in some diseases such as ...
[ 2 ] - Patterns of Vascular Endothelial Growth Factor Expression in Hematopoietic Malignant Cells
Background and Objective: Vascular endothelial growth factor (VEGF) is a cytokine which is overexpressed in many malignant cancers including leukemia. VEGF plays an important role in tumor invasion and metastasis. Determination of the pattern of VEGF expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...
[ 3 ] - اثر داروی ایزوسورباید بر فعالیت ژلاتیناز A و B در رده‌های سلولی لوسمیک
چکید ه سابقه و هدف ژلاتینازها زیرگروهی از ماتریکس متالوپروتئینازها( MMPs ) می‌باشند که نقش مهمی در رشد تومور و آنژیوژنز دارند. MMP-2 و MMP-9 از این نظر از اهمیت ویژه‌ای برخوردار هستند. ایزوسورباید دی نیترات دارویی رایج برای درمان بیماری های قلبی است و اثر مهارکنندگی آن بر رشد تومور و آنژیوزنز گزارش شده است. در این مطالعه، اثر ایزوسورباید دی‌نیترات بر فعالیت ژلاتیناز A و B در رده‌های سلو...
[ 4 ] - اثر ایزوسورباید بر فعالیت ماتریکس متالوپروتئینازها در رده‌های سلولی فیبرو سارکومایی 164-Wehi و لوسمیک 1-THPدر شرایط آزمایشگاهی
Background and purpose: Matrix metalloproteinases (MMPs) are a group of enzymes degredating the extracellular matrix. MMPs have an important role in inflammation, tumor growth, metastasis and angiogenesis. Among the MMPs, MMP1 and MMP2 have special implication in angiogenesis. Isosorbide, as a nitric oxide donor, has been widely used in treatment of many cardiovascular diseases. Besides the inh...
[ 5 ] - Effect of Propranolol on Angiogenic Factors in Human Hematopoietic Cell Lines in vitro
Background: Beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. Anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. Angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in s...
[ 6 ] - بررسی اپی توپ های خطی ایمونوژن ایمونوگلوبولین G انسان به روش ایمونوانفورماتیک
Background and objective : Immunoglobulin G (IgG) is the most abundant antibody in serum and extracellular fluids. The amount of serum IgG is associated to severity of some diseases like immunodeficiency, infections and autoimmunity. Therefore IgG has a high diagnostic value. Immunoinformatic is a branch of immunology which helps in solving of immunologic problems, well understanding of immun...
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