Mohammad Sayyah

[ 1 ] - Evaluation of the Anticonvulsant Activity of the Leaves of Glycyrrhiza glabra var. glandulifera Grown in Iran, as a Possible Renewable Source for Anticonvulsant Compounds

A review of the publications in traditional medicine indicates that the root of Glycyrrhiza glabra L., Fabaceae, is recommended for treatment of epilepsy. As a renewable source, the leaves of G. glabra var. glandulifera growing in Iran were examined for possible anticonvulsant activity. The anticonvulsant activity of the leaves’ ethanol extract and dichloromethane, f1, n-Hexane, f1A, and methan...

[ 2 ] - Evaluation of the Anticonvulsant Activity of the Leaves of Glycyrrhiza glabra var. glandulifera Grown in Iran, as a Possible Renewable Source for Anticonvulsant Compounds

A review of the publications in traditional medicine indicates that the root of Glycyrrhiza glabra L., Fabaceae, is recommended for treatment of epilepsy. As a renewable source, the leaves of G. glabra var. glandulifera growing in Iran were examined for possible anticonvulsant activity. The anticonvulsant activity of the leaves’ ethanol extract and dichloromethane, f1, n-Hexane, f1A, and methan...

[ 3 ] - Assessment of the Optimal Stimulus Pattern to Achieve Rapid Dorsal Hippocampal Kindling in Rats

Introduction: Although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (HK) develops very slowly. Hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. In this article we aimed at finding the optimal stimulus pattern, which yields the fastest HK rate. Methods: Stimulus patterns with different duratio...

[ 4 ] - Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy

Background: Gap junctions (GJs) provide direct intercellular communications that are formed by hexameric protein subunits, called connexin (Cx). The role of Cxs in epileptogenesis has not received sufficient attention. Hippocampus with critical function in epileptogenesis has a wide network of GJs. We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between G...

[ 5 ] - In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures

Background: Resistance to antiepileptic drugs as well as intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. Acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (DHA), make it as a good candidate for designing and development of the new anticonvulsant medications. Methods: Ten DHA-based...

[ 6 ] - Facilitation of Hippocampal Kindling and Exacerbation of Kindled Seizures by Intra-CA1 Injection of Quinine: A Possible Role of Cx36 Gap Junctions

Background: GABAergic interneurons in the hippocampal CA1 area are mutually communicated by gap junctions (GJs) composed of connexin36 (Cx36). We examined the role of Cx36 in CA1 in manifestation of kindled seizures and hippocampal kindling in rats. Methods: Quinine, as the specific blocker of Cx36, was injected into CA1, and kindled seizures severity was examined 10 min afterward. Moreover, qu...

[ 7 ] - Anticonvulsant Effect of Cicer arietinum Seed in Animal Models of Epilepsy: Introduction of an active Molecule with Novel Chemical Structure

Background: Cicer arietinum (Chickpea) is one of the most important harvests in the world with high nutritional value. Lack of essential oils in the seeds of Chickpea is an advantage in search for drug-like molecules with less toxicity. We evaluated anticonvulsant effect of C. arietinum in common animal models of epilepsy. Methods: Dichloromethane extract was obtained from C. arietinum seeds by...

[ 8 ] - Effect of Chronic Intracerebroventricluar Administration of Lipopolysaccharide on Connexin43 Protein Expression in Rat Hippocampus

Background: Hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. We previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) modulates epileptogenesis in rats. There is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. Gap junction channels are formed ...

[ 9 ] - Association between ABCB1-T1236C Polymorphism and Drug-Resistant Epilepsy in Iranian Female Patients

Background: One third of epileptic patients are resistant to several anti-epileptic drugs (AED). P-glycoprotein (P-gp) is an efflux transporter encoded by ATP-binding cassette subfamily B member 1 (ABCB1) gene that excludes drugs from the cells and plays a significant role in AEDs resistance. Over-expression of P-gp could be a result of polymorphisms in ABCB1 gene. We studied the association of...

[ 10 ] - Inhibitory and Dose-dependent effect of intracerebroventricular docosahexaenoic acid on clonic seizures induced by pentylenetetrazole in mice

Introduction: Epilepsy is one of the most common neurologic disorders. Pharmacoresistance and adverse effects of current antiepileptic drugs (AEDs) necessitate development of new drugs and strategies for treatment of epilepsy. Omega 3-Polyunsaturated fatty acids (ω3-PUFAs) are safe nutritional supplements that recently considered for treatment of epilepsy. Anticonvulsant effect of docosahexa...

[ 11 ] - Alterations of the electroencephalogram sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy

Introduction: Temporal lobe epilepsy (TLE) is the most common and drug resistant epilepsy in adults. Due to behavioral, morphologic and electrographic similarities, pilocarpine model of epilepsy best resembles TLE. This study was aimed at determination of the changes in electroencephalogram (EEG) sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy. Analysis of thes...

[ 12 ] - بررسی تغییرات پارامترهای کیندلینگ در مدل آزمایشگاهی صرع الکتریکی کلاسیک پس از ضربه مغزی

زمینه مطالعه: آسیب‌های ناشی از ضربه‌های مغزی (Traumatic brain injury) یکی از مشکلات پزشکی است. یکی از پیامدهای آسیب مغزی، دچار شدن به بیماری صرع (Post Traumatic Epilepsy; PTE) می باشد. هدف: هدف از این مطالعه بررسی تغییرات پارامترهای کیندلینگ در مدل آزمایشگاهی صرع الکتریکی کلاسیک پس از ضربه مغزی می‌باشد. روش کار: 24 سر موش صحرایی نر نژاد ویستار با استفاده از مدل صرعی کیدلینگ الکتریکی کلاسیک ...

[ 13 ] - Anti-Seizure Activity of 1-Adamantane Carboxylic Acid in Common Experimental Seizure Models: Role of Benzodiazepine-GABAA Receptors

Background: Despite introduction of modern antiepileptic drugs, 30% of epileptic patients are still drug resistant. Remarkable three-dimensional spatial structure of AdCA, yet the simplicity of the molecule, makes AdCA a promising lead compound. Methods: Sedative/motor impairment and 24-h mortality rate of AdCA were determined in mice. Impact of AdCA on (1) threshold and occurrence of clonic se...