Nasser Naghdi

[ 1 ] - Intrahippocampal Injection of 3α Diol (a Testosterone Metabolite ) and Indomethacin (3α-HSD Blocker), Impair Acquisition of Spatial Learning and Memory in Adult Male Rats

Hippocampus is essentially involved in learning and memory processes, and is known to be a target for androgen actions. The high density of the androgen receptors in hippocampus shows that there must be some relationship between androgens and memory. Androgen effects on spatial memory are complex and contradictory. Some evidence suggests a positive correlation between androgens and spatial memo...

[ 2 ] - Microinjection of Dihydrotestosterone as a 5α-Reduced Metabolite of Testosterone into CA1 Region of Hippocampus Could Improve Spatial Learning in the Adult Male Rats

CA1 region of hippocampus has an important role in learning and memory. Previous reports have shown that androgens like testosterone and its metabolites are present in high concentration in CA1 region of hippocampus. Androgen receptors have also high density in this region. Therefore, it is suggested that neurohormones in CA1 have an important role in learning and memory. It is likely that...

[ 3 ] - Intrahippocampal Injection of 3α Diol (a Testosterone Metabolite ) and Indomethacin (3α-HSD Blocker), Impair Acquisition of Spatial Learning and Memory in Adult Male Rats

Hippocampus is essentially involved in learning and memory processes, and is known to be a target for androgen actions. The high density of the androgen receptors in hippocampus shows that there must be some relationship between androgens and memory. Androgen effects on spatial memory are complex and contradictory. Some evidence suggests a positive correlation between androgens and spatial memo...

[ 4 ] - Microinjection of Dihydrotestosterone as a 5α-Reduced Metabolite of Testosterone into CA1 Region of Hippocampus Could Improve Spatial Learning in the Adult Male Rats

CA1 region of hippocampus has an important role in learning and memory. Previous reports have shown that androgens like testosterone and its metabolites are present in high concentration in CA1 region of hippocampus. Androgen receptors have also high density in this region. Therefore, it is suggested that neurohormones in CA1 have an important role in learning and memory. It is likely that...

[ 5 ] - بررسی اثر ماندگاری تزریق بتا آمیلویید در ناحیه CA1 هیپوکامپ موش‌های صحرایی نر بالغ بر یادگیری و حافظه فضایی

سابقه و هدف: آلزایمر یکی از شایع ترین بیماری های تحلیل برنده سیستم عصبی است که منجر به از دست رفتن توان فکری، رفتاری و توانایی یادگیری می گردد. هدف از انجام این مطالعه بررسی ماندگاری اثر تزریق بتا آمیلویید ۴۲-۱ در ناحیه CA1 هیپوکامپ موش های صحرایی نر بالغ بر یادگیری و حافظه فضایی توسط ماز آبی موریس می باشد. مواد و روش ها: در این مطالعه از ۴۲ سر موش صحرایی نر بالغ استفاده شد که به طور تصادفی د...

[ 6 ] - Effect of 3 Alpha-Anderostanediol and Indomethacin on Acquisition, Consolidation and Retrieval Stage of Spatial Memory in Adult Male Rats

Background: Testosterone and its metabolites have important roles in learning and memory. The current study has conducted to assess the effect of pre-training, post-training and pre-probe trial intrahippocampal CA1 administration of 3 alpha-anderostanediol (one of the metabolites of testosterone) and indomethacin (as 3 alpha-hydroxysteroid dehydrogenase enzyme blocker) on acquisition, consolida...

[ 7 ] - Effect of Spatial Learning on Hippocampal Testosterone in Intact and Castrated Male Rats

Background: Sex steroids and their receptors exist in hippocampus and affect spatial learning and memory. This study was designed to measure testosterone level of CA1 and to assess the effect of spatial learning on its amount in left and right hippocampus of adult male rats. Methods: Sixteen rats were divided into two intact and castrated groups, and then trained in Morris water maze (MWM). An...

[ 8 ] - تأثیر مکمل ویتامین E بر فعالیت حرکتی و یادگیری فضایی رت های مسن

افزایش سن بر عملکرد حرکتی و کارکردهای شناختی تأثیر منفی میگذارد. ازاینرو شناسایی راهبردهای مناسب برای جلوگیری از کاهش عملکرد شناختی و حرکتی ضرورت مییابد. هدف از این تحقیق، بررسی تأثیر مکمل ویتامین E بر فعالیت حرکتی و یادگیری فضایی رتهای مسن بود. 36 رت نر مسن از نژاد آلبینو – ویستار به طور تصادفی در سه گروه کنترل، ویتامین E و جفتشده قرار گرفتند. رتهای گروه ویتامین E، به مدت 8 هفته، روزانه ...

[ 9 ] - تأثیر فعالیت کوتاه مدت بر حافظه، یادگیری و فعالیت حرکت موش های صحرایی نر

افزایش عملکرد شناختی و حرکتی از اهداف مهم است. هدف از این تحقیق، بررسی تاثیر دویدن روی تریدمیل بر یادگیری فضایی و فعالیت حرکتی رت های نر بود. به این منظور 24 رت نر سالم از نژاد آلبینو- ویستار به طور تصادفی در دو گروه کنترل و فعالیت قرار گرفتند. رت های گروه فعالیت، به مدت یک هفته به فعالیت شدید (دویدن روی تریدمیل) پرداختند. پس از پایان دورة فعالیت، آزمون های ماز آبی موریس و open-field، به ترتیب...

[ 10 ] - Aerobic activity improves spatial learning and motor activity in aged rats

Aging has negative effects on motor and cognitive functions, therefore finding appropriate strategies to prevent the decline of these functions is necessary. It seems that cardiovascular fitness obtained by aerobic activity is a physiological mediator that explains the relationship between physical activity and improved cognitive performance. The aim of this research was to assess the effect...

[ 11 ] - Effects of Voluntary Exercise on Motor Function in Parkinson\'s disease Model of Rats

Background. Previous surveys have shown that motor deficits precede the classical motor symptoms seen in Parkinson’s disease (PD) and that physical exercise may have beneficial effects on PD. Objectives. Here, we evaluated the potential of voluntary exercise to improve motor deficit in experimentally-induced Parkinson’s disease (6-OHDA) rats. Methods. Forty adult Wistar rats were ...

[ 12 ] - Effect of Intra-CA1 injection of estrogen on spatial memory and learning in rats

Introduction: Sexhormones are one of most important factors in difference of learning and memory between tow sexes (male & female). High concentration of estrogen and androgen receptors and mechanism of testosterone and estrogen production in learning and memory center, especially in hippocampus show the role of this receptors, sexhormons and P450 enzymes in spatial memory. Consequently, in thi...

[ 13 ] - prelimbic of medial prefrontal cortex GABA modulation through testosterone on spatial learning and memory

Prefrontal cortex (PFC) is involved in multiple functions including attentional , spatial orientation, short and long-term memory. Our previous study indicated that microinjection of testosterone in CA1 impaired spatial learning and memory. Some evidence suggests that impairment effect of testosterone is mediated by GABAergic system. In the present study, we investigated the interaction of test...

[ 14 ] - Improvement in the downstream processing of rhGH production in Pichia pastoris

Production of human proteins in Pichia pastoris has significant advantages. However, there is still need for improvement in various stages of its downstream processing like clarification and purification. In fact downstream processes are usually the most critical part of production of biotech products. This work aimed to evaluate the effect of two steps added to the downstream processes ...

[ 15 ] - prelimbic of medial prefrontal cortex GABA modulation through testosterone on spatial learning and memory

Prefrontal cortex (PFC) is involved in multiple functions including attentional , spatial orientation, short and long-term memory. Our previous study indicated that microinjection of testosterone in CA1 impaired spatial learning and memory. Some evidence suggests that impairment effect of testosterone is mediated by GABAergic system. In the present study, we investigated the interaction of test...

[ 16 ] - Protein Kinase Cε in the Platelet and Hippocampal Tissue as a Diagnostic Biological Marker in Alzheimer Disease

Introduction: Alzheimer disease (AD) is a neurodegenerative disorder characterized by the progressive loss of memory and other cognitive functions. Protein kinase Cε (PKCε) is an isoform that most effectively suppresses amyloid beta (Aβ) production and synaptic loss. Methods: In this study, spatial learning and memory for treated rats were evaluated by the Morris water maze test. The activity ...