Jaleh Varshosaz
Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
[ 1 ] - Preparation and Characterization of Celecoxib Dispersions in Soluplus®: Comparison of Spray Drying and Conventional Methods
The present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (CLX) in polyvinyl caprolactame–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus® (SOL)) prepared by different techniques. Dispersions of CLX in SOL at different ratios (2:1, 1:1, 1:2, 1:4 and 1:6) were prepared by spray drying, conventional solvent evaporation and melting metho...
[ 2 ] - Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/In-vivo Evaluation in Induced Ulcerative Colitis in Rat
The main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH of 1.2 (2 ...
[ 3 ] - Synthesis of silver nanoparticle using Portulaca oleracea L. extracts
Objective(s): To evaluate the influences of aqueous extracts of plant parts (stem, leaves, and root) of Portulaca oleracea L. on bioformation of silver nanoparticles (AgNPs).Materials and Methods: Synthesis of silver nanoparticles by different plant part extracts of Portulaca oleracea L. was carried out and formation of nanoparticles were confirmed and evaluated using UV-Visible spectroscopy an...
[ 4 ] - Preparation and Characterization of Celecoxib Dispersions in Soluplus®: Comparison of Spray Drying and Conventional Methods
The present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (CLX) in polyvinyl caprolactame–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus® (SOL)) prepared by different techniques. Dispersions of CLX in SOL at different ratios (2:1, 1:1, 1:2, 1:4 and 1:6) were prepared by spray drying, conventional solvent evaporation and melting metho...
[ 5 ] - Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/In-vivo Evaluation in Induced Ulcerative Colitis in Rat
The main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH of 1.2 (2 ...
[ 6 ] - ریزپوشانی آرژنین با کیتوزان و اثر آن بر بقای آمینواسید در جیره غذایی و رشد لارو ماهی قزلآلا(Onchorhynchus mykiss)
در این تحقیق به بررسی فاکتورهای رشد بچه ماهیان قزلآلا تغذیه شده با آرژنین ریزپوشانی شده در مقایسه با آرژنین آزاد پرداخته شد. بدین جهت حدود 400 بچه ماهی 1 گرمی قزل الای رنگینکمان پس از سازگاری با محیط آزمایشی، تحت تغذیه با تیمارهای آزمایشی قرار گرفتند. پس از ارزیابی زمان ماندگاری آمینواسید و آماده سازی نانوذرات کیتوزان، تاثیر مکملها بر روی فاکتور های رشد ماهیان انجام شد. ماهی ها به 4 گروه صدت...
[ 7 ] - بهینه‌سازی ساخت نانو ذرات سیلیکای عامل دار شده به روش همزن مغناطیسی حرارتی و بررسی تأثیر پارامترهای مختلف با استفاده از طراحی فاکتوریال نامتعارف
زمینه و هدف: نانوذرات سیلیکا از سیستم‌های جدید دارورسانی زیست تخریب‌پذیرند که سرعت تخریب بیولوژیک آن‌ها در درون‌تن (In vivo) تحت تأثیر سایز و ساختار سطحی آن‌هاست و به همین دلیل برای کاربردهای بیومدیکال و تثبیت دارویی مناسب‌اند. در این مطالعه هدف بهینه‌سازی اندازه ذره‌ای و پتانسیل زتا، بررسی تأثیر پارامترهای مختلف و نهایتاً به دست آوردن معادلاتی برای تخمین اندازه ذره‌ای و پتانسیل زتای دلخواه در ...
[ 8 ] - Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line
Lipid nanocapsules (LNCs) represent a stable, biocompatible and worthwhile drug delivery system, demonstrating significant potential as gene/drug delivery platforms for cancer therapy. Imatinib, a potent tyrosine kinase inhibitor, has revolutionized the therapy of malignancies resulting from abnormal tyrosine kinase activity. However, its Clinical effectiveness in cancer treatment is h...
[ 9 ] - Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line
Lipid nanocapsules (LNCs) represent a stable, biocompatible and worthwhile drug delivery system, demonstrating significant potential as gene/drug delivery platforms for cancer therapy. Imatinib, a potent tyrosine kinase inhibitor, has revolutionized the therapy of malignancies resulting from abnormal tyrosine kinase activity. However, its Clinical effectiveness in cancer treatment is h...
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