Nader Pestechian

[ 1 ] - Evaluation of the antimalarial effect of Ferulago angulata (Schlecht.) Boiss. extract and suberosin epoxide against Plasmodium berghei in comparison with chloroquine using in vivo test

Background: Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to eva...

[ 2 ] - Evaluation of the antimalarial effect of Ferulago angulata (Schlecht.) Boiss. extract and suberosin epoxide against Plasmodium berghei in comparison with chloroquine using in vivo test

Background: Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to eva...

[ 3 ] - Manipulation of IL-10 gene expression by Toxoplasma gondii and its products

Background: This study was designed to evaluate whether or not T. gondii and its derivatives can change the gene expression level of IL-10 in murine leukocytes in vivo.   Methods: Fifty BALB/c mice were divided into 5 groups, four of which received the excretory/secretory product (ESP) from cell culture medium, the ESP from cell free medium, the Toxoplasma lysate product (TLP) and the a...

[ 4 ] - Vaccine design based on Live attenuated cells of Toxoplasma gondii: a review

Toxoplasma gondii is well- known as a common parasite with high proliferative activity in the nucleated cells. This parasite has infected nearly one third of the people worldwide. Infection can result in chorioretinitis in immunocompetent hosts, encephalitis in HIV/AIDS positive patients and abortion and neonatal loss in congenital toxoplasmosis. Development of vaccines for toxoplasmosis infect...