Jamal Shamsara
Pharmaceutical Research Center, School of pharmacy, Mashhad University of Medical Sciences, Iran
[ 1 ] - Developing a CoMSIA model for inhibition of COX-2 by resveratrol derivatives
Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...
[ 2 ] - Developing a CoMSIA model for inhibition of COX-2 by resveratrol derivatives
Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...
[ 3 ] - A THREE DIMENSIONAL HTLV-1 MODEL WITH INTRACELLULAR AND IMMUNE ACTIVATION DELAYS
In this paper, a three dimensional mathematical model for HTLV-1infection with intracellular delay and immune activation delay is investigated.By applying the frequency domain approach, we show that time delays candestabilize the HAM/TSP equilibrium, leading to Hopf bifurcations and sta-ble or unstable periodic oscillations. At the end, numerical simulations areillustrated.
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