Elaheh Amini
Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
[ 1 ] - In vitro pro apoptotic effect of crude saponin from Ophiocoma erinaceus against cervical cancer
Ophiocoma erinaceus Muller &Troschel (Ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. As, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. Saponin extraction was conducted using conventional method such as f...
[ 2 ] - In vitro pro apoptotic effect of crude saponin from Ophiocoma erinaceus against cervical cancer
Ophiocoma erinaceus Muller &Troschel (Ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. As, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. Saponin extraction was conducted using conventional method such as f...
[ 3 ] - اثر مهاری کروسین بر ملانوژنز در سلول‌های رده ملانومای موشی B16F10
Introduction: Saffron has some applications such as anti-spasmodic and analgesic effects in traditional medicine. The aim of this study was to evaluate the anti melanogenesis and antioxidant properties of crocin (one of the saffron active components) on B16F10 mouse melanoma cell line. Methods: In this experimental study, B16F10 cells were prepared from Pasteur Institute (NCBI) and were grow...
[ 4 ] - بررسی پتانسیل آنتی اکسیدانتی کروسین بر روی سلول‌های بنیادی اسپرماتوگونی نوزاد موش کوچک آزمایشگاهی نژاد Balb/C
هدف: هدف از این پژوهش بررسی اثر کروسین بهعنوان یکی از مواد فعال زیستی زعفران برروی سلول‌های بنیادی اسپرمساز موش است. مواد و روشها: دراین مطالعه آزمایشگاهی سلول‌های بنیادی اسپرماتوگونی موش نوزاد نژاد Balb/C در محیطکشت DMEM/F12 کشت داده شده با غلظتهای کروسین (40، 20، 10،5، 5/2 میکروگرم بر میلی لیتر) بهمدت 6 و 12 روز تیمار شدند برای شناسایی سلول‌های ب...
[ 5 ] - اثر عصاره الکلی خیار دریایی گونه خلیج فارس بر تمایز اوستئوژنیک و آدیپوژنیک سلول های بنیادی مزانشیمی مغز استخوان موش صحرایی
هدف :خیار دریایی بهدلیل دارا بودن ترکیبات بیواکتیو مانند کندروئیتین سولفات در درمان بیماریهای استخوانی مورد توجه است. در زمینه بهکارگیری سلول‌های بنیادی مزانشیمی در ترمیم آسیبهای استخوانی در سالهای اخیر پیشرفتهای خوبی انجام شده است. بنابراین پژوهش حاضر با هدف بررسی تمایز استئوژنیک و آدیپوژنیک عصاره الکلی خیار دریایی گونه خلیج فارس روی سلول‌های بنیادی مغز استخوان موش صحرایی نر نژاد ویستار ...
[ 6 ] - Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via Inhibition of VEGF, Paxillin and MMP-9
Background: Bioactive compounds such as terpenoids, chondroitin sulfate, and polysaccharides with added value can be found in prestine marine creatures. These compounds often do have highly valuable therapeutic applications such as being antioxidant, antitumorogenic, anti-infl ammatory and anti-angiogenic. For the latter, varieties of angiogenesis factors can suppress this issu...
[ 7 ] - Anticancer Properties of Chrysin on Colon Cancer Cells, In vitro and In vivo with Modulation of Caspase-3, -9, Bax and Sall4
Background: The SALL4/Sall4 is constitutively expressed in human and mice. SALL4 mRNA could be used as a marker for the diagnosis of different types of cancers. On the other hand, chrysin has diverse biological properties. Objectives: In the present study, the effect of the chrysin was investigated on the CT26 colon cancer in vitro and in vivo. Furthermore, the expression levels of the stem cel...
[ 8 ] - The synergistic influence of the sea cucumber (Holothuria arenicola) extract and dacarbazine on murine melanoma cancer cells B16F10
Melanoma has been reported a contemporary malignant cancer. Here, anti-cancer effects of sea cucumber extract (SCE) have been examined on melanoma cells and compared with dacarbazine. MTT assay and morphological analysis were performed to evaluate cytotoxic effects of methanolic SCE Also, several methods were exerted to detect cell dying by SCE and dacarbazine. The MTT assay showed that B16F10 ...
[ 9 ] - بررسی اثر حفاظتی عصاره دیواره بدن خیار دریایی گونه خلیج فارس (Holothuria arenicola) در پیشگیری از آسیب القایی میدان الکترومغناطیسی (Hz 50) بر اسپرم و هورمون های جنسی موش کوچک آزمایشگاهی نژاد Balb/C
زمینه و هدف: مطالعات نشان داده است، برخی مواد طبیعی در جلوگیری از آسیب های میدان های الکترومغناطیسی موثر هستند، در پژوهش حاضر اثر حفاظتی عصاره بدن خیار دریایی خلیج فارس در برابر آسیب میدان الکترومغناطیسی با فرکانس 50 هرتز، بر پارامترهای اسپرم موش Balb/C بررسی شده است. روش بررسی: در این پژوهش تجربی آزمایشگاهی 56 سر موش در 7 گروه شاهد، شاهد آزمایشگاهی (حالت خاموش میدان الکترومغناطیسی)، گروه تجربی...
[ 10 ] - اثر حفاظتی عصاره تام ستاره شکننده خلیج فارس Ophiocoma erinaceus بر آسیب کبدی القا شده توسط تتراکلرید کربن (CCL4) در موش صحرایی
Background and Aim: Brittle star possess bioactive compounds which confer the wound healing capacity and regenerative potency of damaged arms and organisms to this creature. The aim of the current study was to assess the protective effect of the star extract on liver damages induced by carbon tetrachloride in adult male Wistar rats. Materials and Methods: In this experimental study,...
[ 11 ] - Anti-inflammatory properties of saponin fraction from (Spiny brittle star) Ophiocoma erinaceus (Müller and Troschel, 1842)
Marine saponins are naturally glycosides compounds which possess important biomedical properties such as anti-cancer, antioxidant and anti-inflammatory. Nevertheless, no systematic studies on the anti-inflammatory potential of brittle star saponin and its underlying mechanisms have been reported. In this study, Ophiocoma erinaceus extracted saponin was investigated for its in vitro anti-inflamm...
[ 12 ] - The Effect of Hydroalcoholic Rosmarinus Officinalis (Rosemary) on Memory Retention Deficit in Young Offspring Rat Induced by Maternal Sleep Deprivation
Background: Maternal sleep deprivation is known to reduce neurogenesis in the hippocampus during pregnancy. Also, it damages and impairs cognitive functions such as learning and memory in the neonates. Objectives: Rosmarinus officinalis (rosemary) extract can play an important role in the treatment of cognitive impairments by inhibiting oxidative stress. This study aimed to investigate the r...
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