Maryam Shekarchi

[ 1 ] - Nonionic Surfactants (Dodecyl Maltoside and Polysorbate 20) Effect on Light induced Aggregation and Conformational Changes of Recombinant Human IFNβ_1b

Liquid protein formulations are prone to form aggregates. The effect of nonionic surfactants such as Polysorbate 20 (PS 20) and n-Dodecyl β-D-maltoside (DDM) on the prevention of aggregation and conformational changes of recombinant human IFNβ-1b (rhIFN β_1b) was explored. Polysorbate has been used in formulations of protein pharmaceuticals. There have been concerns about using PS 20 due to its...

[ 2 ] - Synthesis of N-arylidene-2-(2-Phenoxyphenyl) Acetohydrazides as Anti-Inflammatory Agents

Diclofenac sodium has been used for its anti-inflammatory actions for about 28 years, but since all the non-steroidal anti-inflammatory drugs (NSAIDs) suffer from the lethal gastro intestinal (GI) toxicities, diclofenac sodium is not an exception. The free –COOH group is thought to be responsible for the GI toxicity associated with all traditional NSAIDs. In the present research, the main motto...

[ 3 ] - Nonionic Surfactants (Dodecyl Maltoside and Polysorbate 20) Effect on Light induced Aggregation and Conformational Changes of Recombinant Human IFNβ_1b

Liquid protein formulations are prone to form aggregates. The effect of nonionic surfactants such as Polysorbate 20 (PS 20) and n-Dodecyl β-D-maltoside (DDM) on the prevention of aggregation and conformational changes of recombinant human IFNβ-1b (rhIFN β_1b) was explored. Polysorbate has been used in formulations of protein pharmaceuticals. There have been concerns about using PS 20 due to its...

[ 4 ] - Synthesis of N-arylidene-2-(2-Phenoxyphenyl) Acetohydrazides as Anti-Inflammatory Agents

Diclofenac sodium has been used for its anti-inflammatory actions for about 28 years, but since all the non-steroidal anti-inflammatory drugs (NSAIDs) suffer from the lethal gastro intestinal (GI) toxicities, diclofenac sodium is not an exception. The free –COOH group is thought to be responsible for the GI toxicity associated with all traditional NSAIDs. In the present research, the main motto...

[ 5 ] - معتبرسازی روش کروماتوگرافی مایع با کارایی بالا (HPLC ) جهت شناسایی و تعیین مقدار لیزینوآلانین در شیر خشک نوزادان

سابقه و هدف: لیزینوآلانین طی تهیه و فرآوری شیر خشک در اثر حرارت، pH قلیایی با واکنش حذفی بتا، تشکیل دهیدروآلانین و واکنش با ترکیبات آمین دار ایجاد می‌گردد. در این مطالعه طراحی و معتبر سازی روشی مناسب جهت شناسایی و تعیین مقدار لیزینوآلانین در شیر خشک نوزادان با استفاده از کروماتوگرافی مایع با کارایی بالا (HPLC) مد نظر قرار گرفت. مواد و روش‌ها: در این پژوهش ابتدا شرایط بهینه HPLC (ستون C18، آش...

[ 6 ] - Graphene oxide-based dispersive-solid phase extraction for preconcentration and determination of ampicillin sodium and clindamycin hydrochloride antibiotics in environmental water samples followed by HPLC-UV detection

In the present study, a reusable graphene oxide (GO) based dispersive-solid phase extraction (d-SPE) was synthesized and applied for the analysis of trace ampicillin sodium (AMP) and clindamycin hydrochloride (CLI) in water samples followed by high performance liquid chromatography-UV detection (HPLC-UV). Batch experiments were conducted to investigate the effects of pH and volume of the sample...

[ 7 ] - Graphene oxide-based dispersive-solid phase extraction for preconcentration and determination of ampicillin sodium and clindamycin hydrochloride antibiotics in environmental water samples followed by HPLC-UV detection

In the present study, a reusable graphene oxide (GO) based dispersive-solid phase extraction (d-SPE) was synthesized and applied for the analysis of trace ampicillin sodium (AMP) and clindamycin hydrochloride (CLI) in water samples followed by high performance liquid chromatography-UV detection (HPLC-UV). Batch experiments were conducted to investigate the effects of pH and volume of the sample...