Mehran Kouchek

[ 1 ] - Once versus thrice daily colistin in critically ill patients with multi-drug resistant infections

Objectives: The aim of this study was to evaluate the procalcitonin (PCT) changes in two different high-dose colistin regimens in the treatment of multi-drug resistant MDR gram negative infections in ICU patients. Method: This is a prospective study of adult ICU patients with bacteremia and ventilator associated pneumonia (VAP) caused by MDR gram negative pathogens. Patients were assigned to t...

[ 2 ] - A Randomized Placebo-controlled Trial of Clonidine Impact on Sedation of Mechanically Ventilated ICU Patients

Clonidine has sedative and analgesic properties. Randomized studies examining these properties in mechanically ventilated ICU patients are scarce. This study was designed to assess the impact of clonidine on sedative agent use in mechanically ventilated patients.In a prospective, randomized, double blind, placebo-controlled study in a general ICU of a university medical center in Tehran, Iran, ...

[ 3 ] - Magnesium Sulfate in Exacerbations of COPD in Patients Admitted to Internal Medicine Ward

The purpose of this study was to examine the effect of intravenous magnesium sulfate on patients with COPD exacerbation requiring hospitalization. In this randomized clinical trial 30 patients with COPD exacerbation were studied. Patients were randomly assigned to group A (case) who concurrent with standard therapy received 2g magnesium sulfate in normal saline infused in 20 minutes on days one...

[ 4 ] - Study of the Neuroprotective Effects of Memantine in Patients with Mild to Moderate Ischemic Stroke

Introduction: Ischemic stroke is amongst the top four causes of mortality and the leading cause of disability in the world. The aim of this study was to evaluate the efficacy of a high dose memantine on neurological function of patients with ischemic stroke.Methods: In a randomized, 2 armed, open-label study, patients with mild to moderate cerebral thromboembolic event (CTEE) who admitted to Im...

[ 5 ] - Once versus thrice daily colistin in critically ill patients with multi-drug resistant infections

Objectives: The aim of this study was to evaluate the procalcitonin (PCT) changes in two different high-dose colistin regimens in the treatment of multi-drug resistant MDR gram negative infections in ICU patients. Method: This is a prospective study of adult ICU patients with bacteremia and ventilator associated pneumonia (VAP) caused by MDR gram negative pathogens. Patients were assigned to t...

[ 6 ] - A Randomized Placebo-controlled Trial of Clonidine Impact on Sedation of Mechanically Ventilated ICU Patients

Clonidine has sedative and analgesic properties. Randomized studies examining these properties in mechanically ventilated ICU patients are scarce. This study was designed to assess the impact of clonidine on sedative agent use in mechanically ventilated patients.In a prospective, randomized, double blind, placebo-controlled study in a general ICU of a university medical center in Tehran, Iran, ...

[ 7 ] - Magnesium Sulfate in Exacerbations of COPD in Patients Admitted to Internal Medicine Ward

The purpose of this study was to examine the effect of intravenous magnesium sulfate on patients with COPD exacerbation requiring hospitalization. In this randomized clinical trial 30 patients with COPD exacerbation were studied. Patients were randomly assigned to group A (case) who concurrent with standard therapy received 2g magnesium sulfate in normal saline infused in 20 minutes on days one...

[ 8 ] - Study of the Neuroprotective Effects of Memantine in Patients with Mild to Moderate Ischemic Stroke

Introduction: Ischemic stroke is amongst the top four causes of mortality and the leading cause of disability in the world. The aim of this study was to evaluate the efficacy of a high dose memantine on neurological function of patients with ischemic stroke.Methods: In a randomized, 2 armed, open-label study, patients with mild to moderate cerebral thromboembolic event (CTEE) who admitted to Im...

[ 9 ] - Interim study: Comparison of safety and efficacy of Levofloxacin plus Colistin regimen with Levofloxacin plus high dose Ampicillin/Sulbactam infusion in treatment of Ventilator-Associated Pneumonia due to multi drug resistant Acinetobacte

Due to the emerging antibiotic resistance of Acinetobacter, which is the leading cause of ventilator-associated pneumonia (VAP) in critically ill patients, there is an urgent need for studies comparing various antibiotic regimens for its treatment. In this single blinded randomized clinical trial, adult patients with VAP due to multi drug resistant Acinetobacter (MDRA), were randomly assigned ...

[ 10 ] - Interim study: Comparison of safety and efficacy of Levofloxacin plus Colistin regimen with Levofloxacin plus high dose Ampicillin/Sulbactam infusion in treatment of Ventilator-Associated Pneumonia due to multi drug resistant Acinetobacte

Due to the emerging antibiotic resistance of Acinetobacter, which is the leading cause of ventilator-associated pneumonia (VAP) in critically ill patients, there is an urgent need for studies comparing various antibiotic regimens for its treatment. In this single blinded randomized clinical trial, adult patients with VAP due to multi drug resistant Acinetobacter (MDRA), were randomly assigned ...