Mohammad Mehdi Mahboobian

[ 1 ] - Formulation Development and Evaluation of the Therapeutic Efficacy of Brinzolamide Containing Nanoemulsions

Brinzolamide (BZ) is an intraocular pressure reducing agent with low bioavailability. The purpose of the present study was to overcome this issue by development of BZ containing nanoemulsions (NEs) as an ocular drug delivery system with desirable therapeutic efficacy. Brinzolamide NEs were prepared by the spontaneous emulsification method. Based on initial release studies, twelve formulations w...

[ 2 ] - The Effect of PEG Molecular Weights on Dissolution Behavior of Simvastatin in Solid Dispersions

The purpose of the present study was to investigate the effect of polyethylene glycol (PEG) molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the dissolution behavior of simvastatin. SDs with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spe...

[ 3 ] - Formulation Development and Evaluation of the Therapeutic Efficacy of Brinzolamide Containing Nanoemulsions

Brinzolamide (BZ) is an intraocular pressure reducing agent with low bioavailability. The purpose of the present study was to overcome this issue by development of BZ containing nanoemulsions (NEs) as an ocular drug delivery system with desirable therapeutic efficacy. Brinzolamide NEs were prepared by the spontaneous emulsification method. Based on initial release studies, twelve formulations w...

[ 4 ] - The Effect of PEG Molecular Weights on Dissolution Behavior of Simvastatin in Solid Dispersions

The purpose of the present study was to investigate the effect of polyethylene glycol (PEG) molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the dissolution behavior of simvastatin. SDs with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spe...

[ 5 ] - Brinzolamide-Loaded Nanoemulsions: In vitro Release Evaluation

The aim of this investigation was to design and develop nanoemulsions (NEs) as novel ophthalmic delivery systems for brinzolamide (BZD). Phase behavior of quaternary systems composed of triacetin and CapryolTM 90 (selected oils, screened through the solubility studies), various surfactants (namely, Cremophor RH 40, Brij 35, Labrasol and tyloxapol), Transcutol P (as co-surfactant) an...

[ 6 ] - هیدروژل زیست سازگار بر پایه نانوسلولز: تهیه و بررسی برخی از ویژگی‌ها

در این مطالعه تمرکز بر روی تهیه هیدروژل دوست‌دار محیط زیست بر پایه نانوسلولز به فرم پد می‌باشد. هیدروژل‌ها شبکه‏های سه‏ بعدی آب-دوست و دارای اتصالات عرضی هستند که در تماس با آب متورم شده اما حل نمی‏شوند. در این تحقیق برای تهیه هیدروژل به شکل فیلم، از نانوالیاف سلولزی و هیدروکسی اتیل سلولز با نسبت‌های وزنی (1 به 1، 2 به 1 و 3 به 1) استفاده شد. همچنین برای ایجاد اتصالات عرضی، سیتریک اسید که نسبت ...