Leila Moezi

[ 1 ] - Anti-Diabetic Effects of Amygdalus Lycioides Spach in Streptozocin-Induced Diabetic Rats

Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugarand abnormalities in insulin secretion and action. There are many anti-diabetic plants, whichmight supply useful sources for developing new medicines that can be used in treatment ofdiabetes mellitus. The primary objective of the present investigation is to evaluate the antidiabeticproperties of the aerial ...

[ 2 ] - Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease and stroke. However, the potential benefits of creatine for patients with convu...

[ 3 ] - Anti-Diabetic Effects of Amygdalus Lycioides Spach in Streptozocin-Induced Diabetic Rats

Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugarand abnormalities in insulin secretion and action. There are many anti-diabetic plants, whichmight supply useful sources for developing new medicines that can be used in treatment ofdiabetes mellitus. The primary objective of the present investigation is to evaluate the antidiabeticproperties of the aerial ...

[ 4 ] - Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease and stroke. However, the potential benefits of creatine for patients with convu...

[ 5 ] - بررسی فیتوشیمیایی گیاه رامنوس کورنیفولیا

Background and purpose: Rhamnus cornifolia is one of the species belonging to the rhamnaceae family that is abundantly found in different parts of Iran. Rhamnus frangula is one of the most important species of this family which contains anthraquinones that act as stimulant laxative. In this study we investigated Rhamnus cornifolia Boiss which to the best of our knowledge, no phytochemical study...

[ 6 ] - Protective Effect of Edaravone Against Cyclosporine-Induced Chronic Nephropathy Through Antioxidant and Nitric Oxide Modulating Pathways in Rats

Background: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity. The present study evaluates the protective effect of edaravone on CsA-induced chronic nephropathy and investigates its antioxidant and nitric oxide modu...

[ 7 ] - Current Models for Predicting Drug-induced Cholestasis: The Role of Hepatobiliary Transport System

Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...

[ 8 ] - Current Models for Predicting Drug-induced Cholestasis: The Role of Hepatobiliary Transport System

Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...