Saeed Esmaeili-Mahani

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Iran. | Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

[ 1 ] - In-Vitro Anti-Proliferative and Pro-Apoptotic Properties of Sutureja Khuzestanica on Human Breast Cancer Cell Line (MCF-7) and Its Synergic Effects with Anticancer Drug Vincristine

Satureja khuzestanica Jamzad (Marzeh Khuzestani in Persian) is an endemic plant that iswidely distributed in the southern part of Iran. Despite the number of papers published on thisplant, no one has focused on its anticancer effects. Therefore, the present study was designedto investigate the selective cytotoxic and anti-proliferative properties of satureja khuzestanicatotal extract (SKE). MCF...

[ 2 ] - Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery

Objective(s): The purpose of this study was preparation and evaluation of PVA-Fe3O4 nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells at different pH values. Methods: Fe3O4 nanoparticles were synthesized by coprecipitation...

[ 3 ] - In-Vitro Anti-Proliferative and Pro-Apoptotic Properties of Sutureja Khuzestanica on Human Breast Cancer Cell Line (MCF-7) and Its Synergic Effects with Anticancer Drug Vincristine

[ 4 ] - Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats

Introduction: Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain. Methods: Orofacial...

[ 5 ] - The Effects of Inflammatory Tooth Pain on Anxiety in Adult Male Rats

Introduction: This study aimed to examine the effects of induced inflammatory tooth pain on anxiety level in adult male rats. Methods: The mandibular incisors of 56 adult male rats were cut off and prefabricated crowns were fixed on the teeth. Formalin and capsaicin were injected intradentally to induce inflammatory tooth pain. Diazepam treated group received diazepam 30 minutes...

[ 6 ] - Involvement of Mu Opioid Receptor Signaling in The Protective Effect of Opioid against 6-Hydroxydopamine-Induced SH-SY5Y Human Neuroblastoma Cells Apoptosis

Introduction: The neuroprotective role of opioid morphine against 6-hydroxydopamineinduced cell death has been demonstrated. However, the exact mechanism(s) underlying such neuroprotection, especially the role of subtype receptors, has not yet been fully clarified. Methods: Here, we investigated the effects of different opioid agonists on 6-OHDA-induced neurotoxicity in human neuroblastoma...

[ 7 ] - High glucose condition down-regulates the inhibitory G-protein subunit, Gαi, in pheochromocytoma PC12 cells

Introduction: G-proteins have an important role in the cell signaling of numerous receptors. The situation of G-proteins in health and disease and their critical role in the development of diabetic side effects is an interested scientific field. Here, the changes in the expression of G-protein subunits (Gαi, Gαs and Gβ) were evaluated in hyperglycemic situation of PC12 cells as...

[ 8 ] - Artemether effect and its interaction with vincristine and doxorubicin on human breast carcinoma MCF-7 cells

Introduction: For thousands of years, plants have been used as the main source of drug worldwide. Recently, it has been found out that the plant Artemisia annua and especially its derivatives such as artemether have anticancer properties. Methods: In this study, the anticancer effect of artemether on MCF-7 breast cancer cell line was examined. MTT assay was used to assess the viability of c...

[ 9 ] - Changes in regulator of G protein signaling-4 gene expression in the spinal cord of adrenalectomized rats in response to intrathecal morphine

Introduction: Regulators of G-protein signaling protein negatively control G protein -coupled receptor signaling duration by accelerating Gα subunit guanosine triphosphate hydrolysis. Since regulator of G-protein signaling4 has an important role in modulating morphine effects at the cellular level and the exact mechanism(s) of adrenalectomy-induced morphine sensitization have not been fully cl...

[ 10 ] - Cytotoxic effects of grape (Vitis vinifera, Rishbaba) seed extract on human breast cancer cell line (MCF-7) and its interaction with anticancer drug doxorobicin

Abstract: Introduction: Cancer, a fatal disease, is the second leading cause of death reason exceeded only by cardiovascular disease. Breast cancer is common well known cancers in woman and is the second leading cause of death after lung cancer. In recent years researchers have focused on diet based on herbal medicine for the prevention and treatment of certain types of cancer. Methods: In th...

[ 11 ] - Thymus caramanicus jalas extract reduces serum blood glucose, ameliorates thermal hyperalgesia and motor deficit induced by diabetes in rats

Introduction: Uncontrolled diabetes mellitus could lead to neuropathy in central and peripheral nerve tissues and one of its main signs can be hyperalgesia and motor coordination defect. Due to the blood glucose lowering effect of Thymus species and the presence of polyphenolic compounds with high antioxidant capacity, in this study the effect of Thymus caramanicus jalas extract was investig...

[ 12 ] - Oral administration of Teucrium polium extract ameliorates ovalbumin-induced allergy in rats

Introduction: There are about 120 million people around the world who suffer from allergies. This is a huge number and all these individuals currently use anti-allergic drugs that are associated with numerous side effects. In order to find an appropriate complementary drug from traditional folk medicine, Teucrium polium was examined. Prednisolone was used as a control anti-allergic drug. Me...

[ 13 ] - Olive (Olea europaea L.) leaf extract and its main component (oleuropein) mitigate the development of morphine physical dependence in rats

Introduction: Recently, it has been demonstrated that olive leaf extract and its main component have calcium channel blocker, anti-inflammatory and anti-oxidative properties. However, the effects of olive leaf extract on opioid dependence have not yet been clarified. Methods: To develop morphine dependence, morphine was injected twice daily for 7 days according to an escalating dose in rats...

[ 14 ] - Olive (Olea europaea L.) leaf extract prevents motor deficit in streptozotocin-induced diabetic rats

Introduction:Olive leaves have been recommended in the scientific literature and traditional medicine as a cure for the treatment of diabetes and this plant has powerful antioxidants and neuroprotective effects. Here, we studied the possible effects of olive leaf extract (OLE) on motor deficits in diabetic neuropathy. Methods:The rotarod treadmill test was used to access motor coordination...

[ 15 ] - The Effect of Intrahippocampal Injection of Ascorbic Asid on Spatial Learning and Memory in Adult Male Rats

Introduction: Ascorbic acid (AA) is present in high concentrations with heterogeneous distribution in the mammalian brain. Previous studies have shown that release of various neurotransmitters such as glutamate, acetylcholine and dopamine might be involved in the central AA release. On the other hand all of these neurotransmitters and the region CA1 of the hippocampus are involved in learnin...

[ 16 ] - Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization

Objective(s): Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects through modulating the function of other systems. This study analyzed the interaction between APJ and kappa OPRs (KOR) in cardiac responsiveness to apelin in acute reno-...

[ 17 ] - تأثیر ورزش منظم با تردمیل بر بیان میکروآر ان ای 10b (miR-10b) و فاکتور نوروترفیک مشتق‌شده از مغز (BDNF) در هیپوکامپ موش‌های صحرایی ماده

Background and Aim: The positive effects of exercise on brain function and increased expression of neuronal growth factors, including brain-derived neurotrophic factor or (BDNF), have been proven. To the further investigate the molecular mechanisms of these changes, As well as knowing that miR-10b is one of the BDNF expression regulators, the effect of exercise on the relative expression of miR...

[ 18 ] - تأثیر حاد و بلندمدت تمرین استقامتی بر بیان ژن CGRP در مغز، مایع مغزی نخاعی و سرم رت‌های نر نژاد ویستار

هدف از انجام مطالعة حاضر، تعیین تأثیر حاد و بلندمدت تمرین استقامتی بر بیان ژن پپتید مرتبط با ژن کلسی‌تونین در مغز، مایع مغزی نخاعی و سرم موش‌های صحرایی نر نژاد ویستار بود. تعداد40 حیوان به چهار گروه کنترل، حاد، تمرینی مزمن و تمرین‌کردة حاد تقسیم شدند. گروه حاد یک جلسه تمرین استقامتی و گروه تمرین‌کردة حاد یک جلسه تمرین استقامتی را بعد از 12 هفته تمرین و گروه تمرینی مزمن ...

[ 19 ] - Ginger Extract Reduces Chronic Morphine-Induced Neuroinflammation and Glial Activation in Nucleus Accumbens of Rats

Background: Chronic usage of morphine elicits the production of inflammatory factors by glial cells andinduces neuroinflammation. Ginger (Zingiber Officinale Roscoe) is a medicinal herb that has antiinflammatory properties. It has been reported that ginger shows anti-addictive effects against chronic usageof morphine; however, its influence o...

[ 20 ] - Abnormal hippocampal miR-1b expression is ameliorated by regular treadmill exercise in the sleep-deprived female rats

Objective(s): The protective effect of regular running on sleep deprivation (SD)-induced cognitive impairment has been revealed. In this study, we focused on the effects of regular exercise, sleep deprivation and both of them together on the microRNA-1b (miR-1b) expression and their relation to the behavioral parameters and brain-derived neurotrophic factor (BDNF) expr...

[ 21 ] - Effects of Baneh (Pistacia atlantica) gum on Human Breast Cancer Cell Line (MCF-7) and Its Interaction with Anticancer Drug Doxorubicin

Pistacia atlantica is one of the species of Anacardiaceae that grows in the wild in different regions of Iran. Traditionally, anacardiaceae family has antibacterial, fungicidal and cytotoxic properties. Therefore, the present study was designed to investigate the possible cytotoxic and anti-proliferative properties of Baneh gum. Cytotoxicity of the plant gum was determined using MTT assay on MC...