Mir-Jamal Hosseini
Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. | Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
[ 1 ] - Determinations of Melamine Residue in Infant Formula Brands Available in Iran Market Using by HPLC Method
The contamination of melamine was evaluated in 69 infants along with follow up formula samples collected from the market for the first time in Iran using HPLC method. Since there are no previous data concerning the contamination level of melamine in all brands of infant formula samples consumed using the HPLC method in Iran, this study is the first investigation in this regard. Our results show...
[ 2 ] - Occurrence of Ochratoxin A in Grape Juice of Iran
Ochratoxin A (OTA) is one of the most important mycotoxins that contaminate a broad range of agricultural and food products. In this study, the occurrence of OTA in available brands of grape juice in Iran purchased from retail outlets or producer were determined for the first time using high-performance liquid chromatography (HPLC) with immunoaffinity columns(IAC) as the clean-up step. The aver...
[ 3 ] - Toxicity Mechanisms of Cigarette Smoke on Mouse Fetus Mitochondria
Maternal smoking has been recognized as a common cause of low birth weight, preterm birth and the decrease of gestational age period. Unfortunately, there is an increasing interest within public especially woman in Iran in the tobacco products consumption. On the other hand, the deleterious effect of maternal smoking on human fetus in pregnancy period especially in the first trimester encourage...
[ 4 ] - A Comparison of Toxicity Mechanisms of Cigarette Smoke on Isolated Mitochondria Obtained from Rat Liver and Skin
Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...
[ 5 ] - Toxicity of Arsenic (III) on Isolated Liver Mitochondria: A New Mechanistic Approach
Arsenic exposure mainly through food and water has been shown to be associated with increased incidence of numerous cancers and non-cancer harmful health. It is also used in cancer chemotherapy and treatment of several cancer types due to its apoptogenic effects in the various cancer and normal cell lines. We have already reported that liver is the storage site and important target organ in As ...
[ 6 ] - Involvement of Four Different Intracellular Sites in Chloroacetaldehyde- Induced Oxidative Stress Cytotoxicity
Chloroacetaldehyde (CAA) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). In this research, the cytotoxic mechanisms of CAA in freshly isolated rat hepatocytes were investigated.CAA cytotoxicity was associated with reactive oxygen spec...
[ 7 ] - Detection of Oxytetracycline Residue in Infant Formula by High-Performance Liquid Chromatography (HPLC)
Determination of drug residues in food is of great importance due to their toxicity. Long-term exposure with low level of drug residues could be important, especially in children. Based on document study, oxytetracycline (OTC) is a prophylaxis and treatment agent for great number of diseases and possesses a broad spectrum activity against many pathogenic organisms and can be toxic or cause alle...
[ 8 ] - مروری بر روشهای کاهش میزان افلاتوکسین در خوراک دام و غذای انسان
آلودگی مواد غذایی به سم آفلاتوکسین که متابولیت ثانویه تولیدشده توسط قارچ‌های رشته‌ای می‌باشد، همواره یک مشکل اساسی در مورد ایمنی مواد غذایی مورد مصرف انسان بوده است. در این میان ، آلودگی خوراک مصرفی دام‌ها به دلیل امکان توانایی انتقال متابولیت‌های سمی آفلاتوکسین به سبد غذایی انسان، از طریق مصرف محصولات دامی آلوده، بایستی مورد توجه قرار گیرد. بهترین راه جهت جلوگیری از آلوده شدن مواد غذایی به این...
[ 9 ] - مروری بر روش های شناسایی تقلبات آبلیمو در ایران
مصرف عمومی آبلیموها و بازار پرفروش سبب می شود افراد سودجو برای کم کردن هزینه های تولید به تقلب های متعدد دست بزنند و از این راه سلامت مردم را به خطر انداخته و مشکلات متعددی را برای مسئولان نظارتی مربوطه به وجود آورند. مطالعات نشان می دهد هیچکدام از روشهای ارائه شده توسط سازمان استاندارد ایران، قادر به شناسایی تقلبات آبلیمو نیست و تمامی فاکتورهای پیشنهادی می تواند بوسیله افزودن یکسری مواد ...
[ 10 ] - مروری بر سمیت ملامین در مواد غذایی و جنبه های بهداشتی آن
ملامین (Melamine) یک ترکیب آلی از مشتقات سیانامید است که 66% وزنی آن را نیتروژن تشکیل می‌دهد. ملامین گاهی اوقات به‌طور غیرقانونی به منظور افزایش کاذب مقدار پروتئین به محصولات غذایی به‌ویژه شیر و فرآورده‌های آن اضافه می‌گردد. از طرفی تست‌های استاندارد اندازه‌گیری میزان پروتئین نظیر کجلدال (Kjeldahl)و دیومس (Dumas)، مقدار پروتئین مواد غذایی را با اندازه‌گیری مقدار نیتروژن موجود تخمین می‌زنند. ب...
[ 11 ] - Determinations of Melamine Residue in Infant Formula Brands Available in Iran Market Using by HPLC Method
The contamination of melamine was evaluated in 69 infants along with follow up formula samples collected from the market for the first time in Iran using HPLC method. Since there are no previous data concerning the contamination level of melamine in all brands of infant formula samples consumed using the HPLC method in Iran, this study is the first investigation in this regard. Our results show...
[ 12 ] - Occurrence of Ochratoxin A in Grape Juice of Iran
Ochratoxin A (OTA) is one of the most important mycotoxins that contaminate a broad range of agricultural and food products. In this study, the occurrence of OTA in available brands of grape juice in Iran purchased from retail outlets or producer were determined for the first time using high-performance liquid chromatography (HPLC) with immunoaffinity columns(IAC) as the clean-up step. The aver...
[ 13 ] - Toxicity Mechanisms of Cigarette Smoke on Mouse Fetus Mitochondria
Maternal smoking has been recognized as a common cause of low birth weight, preterm birth and the decrease of gestational age period. Unfortunately, there is an increasing interest within public especially woman in Iran in the tobacco products consumption. On the other hand, the deleterious effect of maternal smoking on human fetus in pregnancy period especially in the first trimester encourage...
[ 14 ] - A Comparison of Toxicity Mechanisms of Cigarette Smoke on Isolated Mitochondria Obtained from Rat Liver and Skin
Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...
[ 15 ] - Toxicity of Arsenic (III) on Isolated Liver Mitochondria: A New Mechanistic Approach
Arsenic exposure mainly through food and water has been shown to be associated with increased incidence of numerous cancers and non-cancer harmful health. It is also used in cancer chemotherapy and treatment of several cancer types due to its apoptogenic effects in the various cancer and normal cell lines. We have already reported that liver is the storage site and important target organ in As ...
[ 16 ] - Involvement of Four Different Intracellular Sites in Chloroacetaldehyde- Induced Oxidative Stress Cytotoxicity
Chloroacetaldehyde (CAA) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). In this research, the cytotoxic mechanisms of CAA in freshly isolated rat hepatocytes were investigated.CAA cytotoxicity was associated with reactive oxygen spec...
[ 17 ] - Detection of Oxytetracycline Residue in Infant Formula by High-Performance Liquid Chromatography (HPLC)
Determination of drug residues in food is of great importance due to their toxicity. Long-term exposure with low level of drug residues could be important, especially in children. Based on document study, oxytetracycline (OTC) is a prophylaxis and treatment agent for great number of diseases and possesses a broad spectrum activity against many pathogenic organisms and can be toxic or cause alle...
[ 18 ] - مروری بر تماس با فتالات‌ها و سمیت آنها
The dialkyl- or alkyl/aryl esters of 1, 2-benzenedicarboxylic acid, which are known as Phthalates, are high-production volume synthetic chemicals and considered as environmental pollutants, due to high production and uses in community, plastics industry and common consuming products. Di-(2-ethylhexyl) phthalate (DEHP) is the most abundant phthalate in the environment. Human exposure with DEHP c...
[ 19 ] - تعیین میزان آلودگی به آفلاتوکسین در ماءالشعیرهای توزیع شده در استان لرستان با استفاده از روش کروماتوگرافی مایع با کارکرد عالی
Background and purpose: Aflatoxins are of the most important groups of mycotoxins recognized to be teratogen, mutagen, and carcinogen. Aflatoxins have been detected in a number of foods including cereals and cereal products. Beers are often derived from malted cereal grain most commonly malted barley and malted wheat. Contaminated cereals to aflatoxins results in malt and beers consumption with...
[ 20 ] - بررسی تاثیر تاکتیک‌های بازاریابی رابطه‌ای بر وفاداری مشتریان از منظر مشتریان شرکت ایرانسل
هدف شرکت‌ها از ایجاد رابطه بلند‌مدت با مشتریان کسب وفاداری آن‌هاست. امروزه برای بازاریابان، بازاریابی رابطه‌ای به عنوان برآورده کننده این هدف بسیار مهمتر رخ می‌نمایاند. تاکتیک‌های بازاریابی رابطه‌ای به عنوان بازوان اجرایی بازاریابی رابطه‌ای موجب حفظ مشتریان موجود و در طی یک کیفیت بالای ارتباطی اعتماد و رضایت آنها جلب و در نتیجه موجب وفاداری آنها می‌گردد. مشتریان وفادار با وجود عوامل محیطی و ت...
[ 21 ] - تأثیر فعالیت بدنی اجباری تردمیل در دوران نوجوانی بر روی علائم افسردگی و فاکتورهای التهابی مغز رت‌های نر بالغ دچار استرس جدایی از مادر
مقدمه: تجربه استرس اولیه در دوران کودکی می‌تواند اثرات زیان بخشی بر مغز و رفتار در ارتباط با ایجاد افسردگی داشته باشد. همچنین پاسخ‌های ایمنی التهابی در ارتباط با پاتوفیزیولوژی افسردگی گزارش شده‌اند و بسیاری از مطالعات تأثیرات مثبت فعالیت بدنی را در برابر استرس گزارش داده‌اند. این مطالعه با هدف بررسی تأثیر فعالیت بدنی بر روی علائم افسردگی و فاکتورهای التهابی مغز انجام شد. روش بررسی: در این ...
[ 22 ] - Exercise during adolescence attenuated depressive-like behaviors and hippocampal mitochondrial dysfunction following early life stress in adult male rats
Purpose: In this study, we assumed that treating animals with an antidepressant agents or voluntary running wheel exercise (RW) during adolescence may have protective effects against early life stress (ELS) which can impact on behavior and mitochondrial function. Evidence indicates that ELS has deleterious effects on brain and behavior and increases the risk of mental disorders such as depressi...
[ 23 ] - Exercise during adolescence attenuated depressive-like behaviors and hippocampal mitochondrial dysfunction following early life stress in adult male rats
Purpose: In this study, we assumed that treating animals with an antidepressant agents or voluntary running wheel exercise (RW) during adolescence may have protective effects against early life stress (ELS) which can impact on behavior and mitochondrial function. Evidence indicates that ELS has deleterious effects on brain and behavior and increases the risk of mental disorders such as depressi...
[ 24 ] - A Review of Nitrate and Nitrite Toxicity in Foods
Agricultural advancement and population growth have prompted increases in food supplies, and higher crop yields have been made possible through the application of fertilizers. Large quantities of livestock and poultry on farms, along with the accumulation of biomass and agricultural residues, can cause contamination of ground water resources and other water sanitation concerns in both developin...
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