Behzad Sharif Makhmalzadeh

[ 1 ] - Loratadine- Loaded Thermoresponsive Hydogel : Characterization and Ex-vivo Rabbit Cornea Permeability Studies

Poor bioavailability of ophthalmic drops is mainly due to drainage through the nasal-lacrimal duct and a very low permeability through corneal epithelium. The aim of our study was to prepare and characterize an ocular hydrogel of loratadine, as an example of a lipophilic drug, to increase drug concentration and residence time at the site of action in the eye. In this study,a 23full factorial de...

[ 2 ] - Optimization of Ibuprofen Delivery through Rat Skin from Traditional and Novel Nanoemulsion Formulations

The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it i...

[ 3 ] - Loratadine- Loaded Thermoresponsive Hydogel : Characterization and Ex-vivo Rabbit Cornea Permeability Studies

Poor bioavailability of ophthalmic drops is mainly due to drainage through the nasal-lacrimal duct and a very low permeability through corneal epithelium. The aim of our study was to prepare and characterize an ocular hydrogel of loratadine, as an example of a lipophilic drug, to increase drug concentration and residence time at the site of action in the eye. In this study,a 23full factorial de...

[ 4 ] - Optimization of Ibuprofen Delivery through Rat Skin from Traditional and Novel Nanoemulsion Formulations

The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it i...