Mohammadreza Jalali Nadoushan
Dept. of Anatomical Sciences and Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
[ 1 ] - Expression of Vascular Endothelial Growth Factor in Nasal Polyp and Chronic Rhinosinusitis
Background: Nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. Vascular Endothelial Growth Factor (VEGF) plays a key role in angiogenesis and cell proliferation. In the present study the effect of VEGF on the development and prognosis of chronic rhinosinusitis and nasal p...
[ 2 ] - Molecular Detection of Ureaplasma urealyticum from Prostate Tissues using PCR-RFLP, Tehran, Iran
Background: In most cases, prostatitis can be caused by a bacterial agent such as Ureaplasma urealyticum. Considering to the cumbersome of the culture method for the detection of Ureaplasma species in clinical samples such as prostate; PCR method that is faster and more appropriate than the cultivation methods, can be utilized for the detection of <em...
[ 3 ] - Endothelium-dependent Effect of Sesame Seed Feeding on Vascular Reactivity of Streptozotocin-diabetic Rats: Underlying Mechanisms
Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of sesame (Sesamum indicum L) seed feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats. Male diabetic rats received sesame seed-mixed food at weight ratios of 3% and 6% for 7 weeks, one week after diabetes in...
[ 4 ] - Ovarian Polycystic Induction with Morphine in Wistar Rat
Background and Objective: The effect of opioids on the reproductive system has been studied as an attractive research field. In this study, the effect of morphine as an analgesic opioid was evaluated on the ovarian polycystic induction in the rat. Materials & Methods: In this study, 24 female virgin Wistar rats weighing 200-250 g were injected with morphine (1-10 mg/kg/day) for 9 days. Control ...
[ 5 ] - Pathological characteristics of uterus in rats with polycystic ovary
Background and Objective: Uterus of rat with polycystic ovary (PCO) may show pathological features. We provided pathological evidence for the rat uterus with NO-induced PCO. Materials and Methods: Wistar rats (weighing 200-250 g) were kept diestrous to receive L-arginine (50 mg/kg) intraperitoneally (i.p.) for 9 days/once a day. Control group solely received saline (1 ml/kg, 9 days/once per ...
[ 6 ] - Study of correlation between vascular endothelial growth factor receptor and some prognostic factors in papillary carcinoma of thyroid gland
Background and Objective: Thyroid cancer is the most frequent endocrine malignancy in the world and papillary carcinoma is the most frequent thyroid carcinoma. Different markers used for determination of prognosis and VEGFR is one of them. The aim of present study was to determine the expression of Vascular Endothelial Growth Factor Receptor (VEGFR) as a prognostic marker in papillary carcinoma...
[ 7 ] - Nitric oxide and endothelium-dependent effect of Tribulus terrestris feeding on aortic reactivity of streptozotocin-diabetic rats
Background and Objective: Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of Tribulus terrestris (TT) feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats and some underlying mechanisms were investigated. Materials and Methods: Male diabetic rats receive...
[ 8 ] - Endothelium-dependent Effect of Sesame Seed Feeding on Vascular Reactivity of Streptozotocin-diabetic Rats: Underlying Mechanisms
Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of sesame (Sesamum indicum L) seed feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats. Male diabetic rats received sesame seed-mixed food at weight ratios of 3% and 6% for 7 weeks, one week after diabetes in...
[ 9 ] - بررسی تراکم ماست‌سل در کارسینوم سلول سنگ‌فرشی و مخاط دیسپلاستیک حنجره
Background and Objective: The role of mast cells in carcinogenesis is improved in many malignant neoplasms but there are scanty literature which show the role of these cells in pathogenesis of progression of dysplastic lesion to invasive squamous cell carcinoma (SCC). The aim of this study was comparison of mast cell density between squamous cell carcinoma and dysplastic laryngeal mucosa to inv...
[ 10 ] - بررسی بیان وضعیت کاتپسینD در سرطا ن اولیه پستان و ارتباط آن با عوامل موثر در پیش آگهی
Introduction & Objective: The breast cancer is the most common malignancy in women even according to the new studies this is concluded that the breast cancer in women is the most essential and important oncology’s disease .This malignancy is a suitable example of the use of biologic markers to learn more about prediction, incidence, diagnosis, treatment and outcome .One of this markers is cat...
[ 11 ] - اثر عصاره آبی گیاه آلوئهورا (Aloe vera L.) در بیان گیرنده P75NTR و نوروتروفین BDNF پس از ضایعه فشاری طناب نخاعی در موش‌های بزرگ
به‌منظور ارزیابی اثر عصاره آبی آلوئهورا (Aloe vera L.) در حیات سلول‌های عصبی حرکتی، بیان گیرنده مرگ (P75NTR و نوروتروفینمنتج از مغز) BDNF مورد بررسی قرار گرفت. 24 موش بزرگ بالغ ماده نژاد اسپراگ داولی از انستیتو رازی تهیه شد. حیوانات به 4 گروه: 1- لامینکتومی (مهره 11-9 پشتی) و تزریق عصاره آبی آلوئهورا، 2- لامینکتومی و تزریق عصاره آبی آلوئهورا به همراه فشار بر نخاع، 3- لامینکتومی و تزریق سرم ف...
[ 12 ] - فعالیت‌های ضد میکروبی، آنتی‌اکسیدانی، هماتولوژی و سمیت سلولی اسانس لیموترش (Citrus limon L.)
در مطالعه حاضر فعالیت‌های ضد میکروبی، آنتی‌اکسیدانی، هماتولوژی و سیتوتوکسسیته اسانس لیموترش (Citrus limon L.) مورد آزمایش قرار گرفت. نمای حساسیتی میکروارگانیسم‌ها در برابر اسانس لیمو براساس حساسترین به مقاومترین به‌ترتیب زیر بود: E.coli> K. pneumonia> S. aureus> Streptococcus faecalis> Candida albicans> P. aeruginosa. حداقل غلظت‌های مهارکنندگی (MIC) و کشندگی (MBC) اسانس تازه تعیین گردید. اسانس،...
[ 13 ] - بررسی اثر عصاره آبی سیر بر یافته‌های بالینی خرگوشهای آلوده به سالمونلا تیفی‌موریوم
یکی از عفونتهای مهم روده‌ای به‌خصوص در کشورهای در حال توسعه، عفونت با سالمونلا است. با افزایش مقاومت باکتریایی به آنتی‌بیوتیکها، توجه به توسعه انواع آنتی‌باکتریال‌ها برای کنترل عفونت افزایش یافته است. یکی از روشهای درمانی و کنترل علائم که از زمانهای قدیم مرسوم بوده، استفاده از گیاهان دارویی می‌باشد. در این مطالعه، اثر سیر در درمان و کاهش علائم بالینی عفونت روده‌ای با سالمونلا تیفی‌موریوم بررسی ...
[ 14 ] - بررسی وضعیت سیتوکراتین 7 در سرطان اولیه پستان و ارتباط آن با عوامل مؤثر در پیش آگهی
سابقه و هدف: سرطان پستان شایع ترین بدخیمی در زنان است.از انواع مارکرهای بیولوژیک تومور در تعیین پیش آگهی و پیش بینی پاسخ بیماران به رژیم های درمانی استفاده میگردد.سیتوکراتین 7 در سرطان پستان و ارتباط آن با درحه بد خیمی،مرحله تومور ودرگیری گره های لنفاوی می باشد. مواد وروشها: این مطالعه به روش مقطعی روی 75 نمونه بیماران مبتلا به سرطان پستان در بیمارستان شهید مصطفی خمینی طی سالهای 1383 -1379 ...
[ 15 ] - Cytokeratin7 expression in gastric and colorectal adenocarcinoma: Correlation with prognostic factors
Background: Gastric and colorectal adenocarcinoma are the second and the fifth most common cancers in Iran, respectively. Expression of cytokeratin 7 (CK7) is established in most malignancies including gastric and colorectal adenocarcinoma. Demonstration of Ck7 could be related to prognostic factors and help to the better management of the patients. The objective of our study was to evalu...
[ 16 ] - بررسی ارتباط بین بیان پروتئین E-cadherin در کارسینوم پاپیلری تیروئید با برخی عوامل مؤثر بر پیش‌آگهی آن
اهداف: سرطان تیروئید شایع ترین بدخیمی اندوکرین و کارسینوم پاپیلری شایع ترین سرطان تیروئید است. مارکرهای بیولوژیک مختلفی از جمله E -کادهرین که یک پروتئین اتصال سلولی است در تعیین پیش آگهی بیماران مورد استفاده می باشد. هدف از انجام این مطالعه تعیین فراوانی بیان ای-کادهرین در سرطان تیروئید وارتباط آن با برخی عوامل مؤثر بر پیش آگهی بود. روش ها: این بررسی بر روی 73 نمونه بیماران مبتلا به سرطان ...
[ 17 ] - Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat
Background and Objective: Morphine can cause harmful effects in the ovaries. The silver nanoparticles (Ag-NPs) used in health care because of antimicrobial properties, can diffuse into the brain blood barrier. This study investigated the protective effect of Ag-NPs on the induction of polycystic ovary (PCO) due to injection of morphine intra-ventromedial hypothalamus (intra-VMH) of rat compared...
[ 18 ] - Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum
Objective(s): With no substantial cost, we injected L-arginine into the rat’s corpus callosum (CC) to create animal model of multiple sclerosis (MS) and investigated the pre-injection effect of gold nanoparticles (GNPs). Materials and Methods: Adult male Wistar rat (250-300 g) was surgically cannulated at the CC, and after recovery it was injected L-arginine (3-200 µg/rat, intra-CC) once ...
[ 19 ] - Interaction of sulpiride with morphine in induction of male rat infertility
Introduction & Objective: Male fertility depends on the proper function of a complex system of organs. Harmful effects of morphine on male reproduction and fertility are well documented. Dopamine facilitates sexual behavior in different animal species. The antagonizing of dopamine D2 receptors with sulpiride was aimed to investigate the interaction of dopaminergic system with morphine-induced i...
[ 20 ] - Serology Testing for SARS-CoV-2: Benefits and Challenges
As COVID-19 was declared as a pandemic by the World Health Organization (WHO) in March 2020, it is an emerging need to discuss different aspects of this pandemic. In any pandemic, valid and rapid laboratory diagnostic tests are critically important for early diagnosis, which will increase the rate of successful treatment and more importantly prevent the spread of the disease.
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