Simindokht Shirvani-Arani
Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
[ 1 ] - Development and assessment of 153Sm-zoledronate complex as a possible bone pain palliative agent
Introduction:In this work, 153Sm-zoledronate (153Sm-ZLD) was studied using computational chemistry methods and prepared for possible use in bone pain palliation therapy. Methods: The Sm(ZLD)2.7H2O complex was synthesized and characterized in solid state using computational chemistry methods followed by 153...
[ 2 ] - Production of no-carrier-added Ho-166 for targeted therapy purposes
Introduction:Holmium-166 radionuclide is one of the most effective radionuclides used for targeted therapy with theranostic properties. One method to produce this radioisotope is via the decay of its parent (indirect method). In this study applicability of extraction chromatography (EXC) for separation of no carrier added 166Ho from neutron-irradiated natura...
[ 3 ] - Comparative studies of extraction chromatography and electro-amalgamation separation to produce no-carrier added 177Lu by Tehran research reactor
Introduction:Owing to its favorable radionuclidic characteristics, such as tl/2 = 6.73 day and Eβ (max) = 497 keV and ease of its large-scale production using medium flux research reactors, lutetium-177 (177Lu) is an attractive radionuclide for various therapeutic applications. No carrier added (NCA) 177Lu was obtained by thermal neut...
[ 4 ] - Radiosynthesis and evaluation of ytterbium-175 labeled bleomycin as therepeutic agent
Introduction: Bleomycins are DNA-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as Yb-175. In this work the development of Yb-175 bleomycin (175Yb-BLM) has been reported. Methods: Yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural Yb2O<...
[ 5 ] - Production and quality control of 166Ho-Chitosan for therapeutic applications
Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...
[ 6 ] - Production, quality control and biological evaluation of 153Sm-EDTMP in wild-type rodents
Introduction: Nowadays various bone pain palliative therapeutic agents have been developed for bone metastases. Among those, 153Sm-ethylenediamine tetramethylene phosphonic acid (153Sm-EDTMP) is the major therapeutic agent which is widely used in the world. In this study, production, quality control and biodistribution studies of this therapeut...
[ 7 ] - Assessment of radon-222 and radium-226 radioactivity concentration in the mineral and drinking water of Sareyn city
The main objective of this research is measurement and assessment of the Radon-222 and Radium-226 radioactive levels in mineral water and drinking water in the Sareyn city. The guidelines used for Radon-222 and Radium-226 radiation sampling and analysis were ASTM D: 5072-09 and ISO 13165-1: 2013, respectively. The concentration of Radon-222 and radium-226 in mineral water and drinking water sam...
[ 8 ] - امکان‌سنجی تولید رادیونوکلید صنعتی پرومتیم-147 به روش پرتودهی نوترونی نئودیمیم در رآکتور تحقیقاتی تهران
پرومتیم یکی از عناصر گروه لانتانیدها است که گرچه در زمره عناصر نادر خاکی دستهبندی میگردد، اما هیچ یک از ایزوتوپهای این عنصر به‌صورت طبیعی بر روی کره زمین یافت نمیشود. تمامی ایزوتوپهای این عنصر رادیواکتیو هستند. رادیوایزوتوپ Pm147 به‌دلیل ویژگیهای مناسب، یک رادیونوکلید مورد توجه در صنعت است. استفاده از انرژی گرمایی ناشی از واپاشی ذره بتا، چشمه‌های نوری یا ابزارهای بتاولتاییک، چش...
نویسندگان همکار