Armaghan Fard-Esfahani

[ 1 ] - Comparing diagnostic performance of 131I-metaiodobenzylguanidine (131I-MIBG) and 99mTc-hydrazinonicotinyl-Tyr3-Octreotide (99mTc-HYNIC-TOC) in diagnosis and localization of pheochromocytoma and neuroblastoma

Introduction: The present study was aimed to assess the diagnostic performance of the two imaging methods of 131I-metaiodobenzylguanidine (131I-MIBG) and 99mTc-hydrazinonicotinyl-Tyr3-Octreotide (99mTc-HYNIC-TOC) in diagnosis and localization of pheochromocytoma and neuroblastoma. Methods: This study ...

[ 2 ] - Radiation induced myocardial perfusion abnormalities in patients with left breast cancer: A prospective study with short and long term follow up

Introduction:The external beam radiation therapy for patients with left breast cancer at the mastectomy site may cause myocardial perfusion abnormalities. We intended to study the change of these abnormalities at short and long term post radiotherapy follow up. Methods: Twenty patients with left and 20 patients with right breast cancer comprised the exposed an...

[ 3 ] - Muscle perfusion scan for prediction of anticipated diabetic foot ulceration

Introduction:We evaluated the performance of muscle perfusion scan (MPS) to assess muscle perfusion reserve (MPR) for prediction of incident diabetic foot ulcerations (DFU). Methods: We recruited 41 diabetic patients without any history of DFU. Five mCi 99mTc-MIBI was injected intravenously during repetitive dorsal and plantar right foot flexions. T...

[ 4 ] - Factors influencing the pattern and intensity of myocardial 18F-FDG uptake in oncologic PET-CT imaging

Introduction:Myocardial 18F-FDG uptake is highly variable in oncologic whole body 18F-FDG PET/CT studies, ranging from quite intense to minimal distribution. Intense or heterogeneous myocardial 18F-FDG uptake is undesirable as it may interfere with the visual or quantitative evaluation of tumoral invasion and metastases in pericardium, myocardiu...

[ 5 ] - How to manage patients with undetectable thyroglobulin but thyroid residue after radioiodine ablative therapy in differentiated thyroid carcinoma, retreatment or observation?

Introduction:Differentiated thyroid carcinoma (DTC) follow-up after thyroidectomy and radioiodine-ablation is performed mainly by thyroglobulin (Tg), diagnostic iodine-131 whole body scan (DxWBS) and sonography. Some patients with undetectable Tg have thyroid-bed uptake after ablation in whom decision making regarding the need for retreatment is still controversial. Me...

[ 6 ] - Effectiveness and complications of 153Sm-EDTMP in palliative treatment of diffuse skeletal metastases

Introduction: The aim of the present study was to evaluate the efficacy and safety profile of bone palliative therapy following administration of 153Sm-EDTMP in patients with intractable metastatic bone pain. Methods: Sixteen patients (9 male, 7 female) aged 29-80 years (57.3±16.7 years) with severe metastasis-related bone pain resistant to analgesic medications were enrolled in the...

[ 7 ] - Evaluation of myocardial perfusion and function after kidney transplantation by Gated SPECT myocardial perfusion scintigraphy

Introduction: The aim of this study was to evaluate the effect of successful kidney transplantation (KT) on myocardial perfusion and left ventricular function by both qualitative (visual) interpretation and semiquantitative parameters, using myocardial perfusion scintigraphy with gated-single photon emission computed tomography (gated-SPECT) in patients suffering from end-stage renal disease. ...

[ 8 ] - Additive clinical value of bone scintigraphy in patients with malignant tumors with absence of localized bone pain: A report on most common sex-related cancers

  Introduction: Almost all malignant tumors have the potential to eventually produce bone metastasis. The aim of the current study was to report the distribution pattern and imaging characteristics of bone metastases detected by conventional whole body bone scintigraphy in patients with different types of malignancies and to assess their relationship with the complain...

[ 9 ] - Radioiodine therapy for hyperthyroidism

Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. The method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. Iodine-131 (I-131) acts by the destructive effect of short-range beta radiation on ...

[ 10 ] - Evaluation of 99mTc-Ubiquicidin 29-41 scintigraphyin in differentiation of bacterial infection from sterile inflammationin diabetic foot

  Introduction: Ubiquicidin (UBI) 29-41 is a synthetic antimicrobial peptide that binds with the microbial cell membrane at the location of infection. This study was conducted to evaluate its probable efficacy as an infection-imaging agent with potential to differentiate bacterial infection from sterile inflammation in humans. Methods: Fifteen diabetic foot patients ...

[ 11 ] - Bone scan with incidental visualization of the entire colon

  A 57-year-old male with history of prostatectomy, cyctectomy, cecal urinary diversion for invasive prostate cancer and with a recent rise in PSA level, was referred for bone scintigraphy to rule out osseous metastatic disease. An interesting finding was abnormal tracer accumulation throughout the large bowel, which was proved to be due to urinary diversion.

[ 12 ] - The value of myocardial perfusion imaging with Tc-99m MIBI for the prediction of perfusion improvement after percutaneous transluminal coronary angioplasty

  Introduction: Percutaneous transluminal coronary angioplasty (PTCA) is an effective method for revascularizing of stenotic coronary vessels. Lack of response to this treatment, either in symptomatic or asymptomatic patients, is usually due to incomplete revascularization, restenosis, and/or irreversibility of myocardial perfusion. Introduction of a noninvasive metho...

[ 13 ] - McCune-Albright syndrome: Report of a case

  A 29- year old female with bone pain and history of precocious puberty was referred for bone scintigraphy. On physical examination café au lait macular spots were noted on her neck, buttocks and left leg. Bone scan showed multiple areas of intense increased activity which was in favour of polyostotic fibrous dysplasia. Considering the presence of polyostotic fibrous...

[ 14 ] - The pattern of brain perfusion SPECT in non-medicated schizophrenic patients

  Introduction: Studies with single photon emission computed tomography (SPECT) have revealed inconsistent changes of regional cerebral blood flow (rCBF) in schizophrenia. Some studies investigated the rCBF and its relationship with psychopathology, positive and negative symptoms in treated patients. However, there is a little information about the pattern of rCBF in ...

[ 15 ] - Platelet-based MPLE algorithm for denoising of SPECT images: phantom and patient study

Introduction: In this study the evaluation of a Platelet-based Maximum Penalized Likelihood Estimation (MPLE) for denoising SPECT images was performed and compared with other denoising methods such as Wavelets or Butterworth filtration. Platelet-based MPLE factorization as a multiscale decomposition approach has been already proposed for better edges and surfaces representation due to Poi...

[ 16 ] - Myocardial perfusion scan accuracy in detection of coronary artery disease - Comparison with exercise stress test [Persian]

Introduction: In patients with coronary artery disease (CAD) noninvasive evaluation for detection of ischemia is important to avoid invasive interventions like angiography. Exercise stress test is conventionally the first study used in evaluation of CAD. Considering the noninvasive nature of the myocardial perfusion scan, we decided to compare its accuracy with stress test. Methods: Patie...

[ 17 ] - Agreement of two methods of planar and SPECT scintigraphy with 99mTc- RBC in detection of liver hemangioma [Persian]

Introduction: Hemangiomas are the most frequent benign tumors of the liver and detecting them from metastasis or other malignant hepatic tumors is of outmost importance. 99mTc- RBC scan is highly specific and is the method of choice for this differentiation. This scintigraphy is performed in Planar and SPECT modes. These two procedures are in agreement most of the times, however since SPE...

[ 18 ] - Catheter related artifacts on bone scans: report of two cases

Bone scanning using the 99mTc-phosphate analogs is an established diagnostic modality and a commonly requested radioisotope examination for a variety of pathologies involving the skeleton, such as osteomyelitis, bony metastases, and occult fractures. The bone scan is one of the most commonly requested procedure in most nuclear medicine department. The images show areas of increased and de...

[ 19 ] - Myocardial 99mTc-MDP uptake on the bone scintigraphy in the hemodialysis-associated amyloidosis: A case report [Persian]

Amyloidosis is characterized by an abnormal extracellular deposition of amyloid in different organs, where it usually causes some type of dysfunction. Its cause is unknown. Five different types of amyloidosis have been described according to the underlying disease; immunoglobulin amyloidosis, familial amyloidosis, senile systemic amyloidosis, secondary amyloidosis and hemodialysis-associa...

[ 20 ] - Radioiodine treatment effects on lacrimal glands function in patients with thyroid cancer [Persian]

  Introduction: There is a limited number of case reports published in the past decade confirming the radio-iodine presence in the tear. These observations as well as reported cases of salivary and lacrimal gland dysfunction after radioiodine therapy stimulated investigators to clarify whether lacrimal gland function can be affected post-radioiodine therapy. Hence we ...

[ 21 ] - Evaluation of ِdiagnostic role of 99mTc-Tetrofosmin scintigraphy in cold thyroid nodules [Persian]

Introduction: Various radiopharmaceuticals, including 67Ga, 201Tl, and 99mTc-sestamibi have been used to differentiate benign from malignant thyroid nodules. 99mTc-Tetrofosmin, a lipophilic cationic radiotracer, and 99mTc-sestamibi have also been reported to accumulate in thyroid tumors. In this study, we evaluated the role of 99mTc-Tetrofosmin in the differentiation of malignant from ben...

[ 22 ] - Accuracy of SPECT bone scintigraphy in diagnosis of meniscal tears

Introduction: Scintigraphy has been considered as a useful tool in the assessment of meniscal tears. Our objective was to assess the accuracy of single photon emission tomography (SPECT), using MRI as the gold standard, in the diagnosis of meniscal tears. Materials and Methods: Between January 2003 and February 2005, 45 patients were studied with SPECT and MRI. Results: The respective sen...

[ 23 ] - Dystrophic calcinosis cutis and SLE; the bone scan pattern [Persian]

A 21 years old woman presented with a history of SLE and skin lesions on the arms, trunk, and abdomen. The left gluteal region was ulcerated and painful and occasionally extruded a chalky white material. The patient referred from rheumatology department for osteomyelitis assessment. On physical examination the patient had hard, nontender lesions on the proximal arms, lower abdomen and low...

[ 24 ] - The value of myocardial perfusion imaging in differentiating between idiopathic dilated cardiomyopathy from the ischemic form [Persian]

Introduction: Differentiating between ischemic cardiomyopathy (ICM) and idiopathic dilated cardiomyopathy (IDCM) is important as coronary revascularization can improve prognosis in the ischemic subgroup. Due to inherent problems of coronary angiography in patients with depressed ejection fraction (EF) introducing a noninvasive tool to diagnose those who will benefit from angiography seems...

[ 25 ] - Studying the specificity of bone SPECT for differentiating malignant from benign lesions in the vertebral column of the patients with a known primary malignancy [Persian]

  Metastatic survey of the patients with known primary malignancies with bone scan is one of the most common studies in nuclear medicine. Unfortunately the conventional planar bone scan has a very low specificity for differentiating benign from malignant lesions especially in the spinal column. In this study, we compared the specificity of SPECT imaging and convention...

[ 26 ] - The value of Tc-99m MIBI scintigraphy in active diseases and remission phase of multiple myeloma [Persian]

[ 27 ] - Reverse redistribution in the myocardial perfusion scan with ²º¹Tl [Persian]

Reverse redistribution pattern is defined as decreased activity in the myocardium in the rest phase of the myocardial perfusion scan in comparison with the stress images. There are many studies concerning the etiology and clinical significant of this phenomenon in nuclear medicine literature. The dominant idea about etiology of reverse redistribution is early wash out of the radiotracer f...

[ 28 ] - Effects of treatment with radioiodine (¹³¹I) on the gonadal function of the hyperthyroid patients

Introduction: Hyperthyroidism is a relatively common disorder caused by different etiologies. Graves’ disease, and toxic-nodular goiter (Plummer’s disease) are among the most common causes. Treatment with radioiodine is considered to be the treatment of choice in many of the patients. Higher biological half-life of ¹³¹I in hyperthyroid patients as compared with patients with differentiate...

[ 29 ] - ¹³¹I-MIBG scintigraphy in Carcinoid tumor with liver metastases (Case report) [Persian]

A 65 years old male presented with abdominal pain (R.U.Q) and constipation, associated with weight loss and anorexia since 40 days prior to admission. Serum biochemical tests were normal. Colonoscopy showed hemorrhagic polypoid lesion in the cecum. Barium enema revealed filling defect in the cecum. Sonography revealed a target-shaped lesion (3cm×2.5cm) in upper segment of the right hepati...

[ 30 ] - Contamination monitoring of Na¹³¹I levels in therapy unit of Research Institute for Nuclear Medicine, Tehran University of Medical Sciences by indirect method (Wipe test) [Persian]

Contamination with radiopharmaceuticals in nuclear medicine centers in addition to being a health concern requires time-consuming decontamination efforts. According to NRC (Nuclear Regulatory Commission) contamination should be monitored in nuclear medicine centers where radiopharmaceuticals are prepared and administrated at the end of each working session; otherwise, contamination spread...

[ 31 ] - Radioiodine therapy effects on salivary gland function in patients with differentiated thyroid cancer [Persian]

Salivary gland involvement is one of the radioiodine therapy complications. Salivary gland scintigraphy in quantitative mode can accurately evaluate salivary gland function. Methods: Salivary gland scintigraphy was performed with Tc-99m Pertechnetate, at the time of iodine therapy as a basic study and then 3 weeks and 3 months afterwards. Ejection Fraction (EF) of parotid and submandibula...

[ 32 ] - The value of the Gated 99mTc-MIBI SPECT in differentiation of fixed myocardial lesions [Persian]

Fixed myocardial defects in both stress and rest images, could be artifactual as a result of soft tissue attenuation. To increase specificity and identify the false positive results, we used gated technique to evaluate the wall motion and wall thickening as an index to differentiate real ischemic lesions from artifactual defects. 93 patients were studied. In 46 patients (48.8%) fixed perf...

[ 33 ] - Radionuclide shuntography in a hydrocephalic patient

Radionuclide shuntography is a safe and simple method to determine shunt patency and analyze changes in CSF (Cerebro-Spinal-Fluid) flow. We present a case of complicated CSF shunt, in which radioisotopic scan correctly identified disconnection of the shunt tubing system localizing the site of extravasation accurately. The findings were confirmed by surgery performed for correction of the ...

[ 34 ] - Clinical course and treatment response in patients with Thyroid hot nodule [Persian]

This is a retrospective study on clinical course and treatment response of patients with thyroid hot nodule, referred to nuclear medicine department of Shariati Hospital from 1360 to 1377. From the total 58 patients with average age of 43 yr and incidence peak of 40 yr, 81% were female and 19% were male. 64% of the patients were thyrotoxic and 36% were euthyroid at presentation. Thyrotoxi...

[ 35 ] - Dose Nitroglycerine enhance detection of viable myocardium by Tl-201 SPECT? [Persian]

It is suggested that sublingual nitroglycerine can improve the ability of T1-201 for detection of viable myocardium. Methods and Results: In a randomized, double blind study, 50 patients who had fixed defects on stress-redistribution scan, were randomized into two groups. In group I, patients received 0.4-0.8 mg sublingual nitroglycerine, before T1-201 reinjection. In group II, reinjectio...

[ 36 ] - Comparison of pretreatment and post-treatment whole body scan results (WBS) with I-131 in 94 patients with differentiated Thyroid cancer (DTC) [Persian]

Discrepancy between pre & post treatment WBSs (Low dose & high dose, respectively) is reported. The aim of this study was determination the post-treatment WBS role in the diagnosis of lesions not identified by the pretreatment one. In this study 94 patients (pts) with DTC were evaluated. The results of pre & post treatment WBSs were compared. Overall, 25.6% of pts revealed more positive l...

[ 37 ] - Quantitative evaluation of normal uptake of mandibular condyle in bone scan with Tc 99m-MDP [Persian]

Unilateral condylar hyperplasia is the main cause of mandibular asymmetry. Radionuclide bone scanning is a useful procedure for functional evaluation of temporomandibular joint. In this study, 39 patients with normal bone scan and no facial asymmetry were studied. All patients were below 22 years of age. Normal condylar uptake was determined in this group of patients. Right & left condyla...

[ 38 ] - Quantitative assessment of salivary gland function by radioisotopic scanning in a randomized trial of Pilocarpine for prevention of radiation induced Xerostomia [Persian]

Introduction: Radioisotope scanning is the best method for objective assessment of salivary gland function. Thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. Methods: Patients randomized in placebo-controlled trial of...

[ 39 ] - Evaluation of response to I-131 ablative therapy in patients with differentiated thyroid carcinoma: A five year retrospective study [Persian]

Differentiated thyroid carcinomas usually show good uptake and response to I-131 ablative treatment. In this study, 90 patients following near total thyroidectomy who were referred to our institute for I-131 therapy are retrospectively studied. The patients are divided in two groups. Group 1 revealed complete ablation after one dose of I-131. Group 2 needed more than one dose of I-131 for...

[ 40 ] - Retrospective study of clinical course and treatment response in Graves’ disease [Persian]

In this report, the clinical course and treatment response of 210 patients with Grawes’ disease referred to the research institute for nuclear medicine were studied. The disease was more common in 3rd and 4th decades and more frequent in women (F/M=4). Treatment response with antithyroid drugs was about 50%, whereas 80% of the patients treated by I-131 showed positive response. There was ...

[ 41 ] - Bone scan in Erdheime Chester disease [Persian]

In spite of very high sensitivity, bone scan is quite nonspecific in evaluation of bony lesions. In interpretation of bone scan special attention to patient’s clinical presentation and correlation with other lab and imaging modalities should be paid. In this report a patient with Erdheim Chester disease a rare and unusual form of lipidosis is presented and the pattern of 99mTc-MDP bone sc...

[ 42 ] - 99mTc-RBC scan in evaluation of mycotic aneurysm [Persian]

Mycotic aneurysm is an uncommon but very important complication of subacute infectious endocarditis. It is usually asymptomatic but often causes sudden and massive bleeding with high mortality rate. 99mTc-RBC scan is a noninvasive method for detection of mycotic aneurysm throughout the body. In this report two cases with mycotic aneurysm are presented and the usefulness of 99mTc-RBC scan ...

[ 43 ] - New techniques in nuclear medicine for tumor detection [Persian]

Widespread studies on tumor diagnosis has led to the development of techniques with greater sensitivity and improved specificity for detection of occult and small subclinical tumors. Tumor imaging by radiolabeling of tumor-specific antibodies (Immunoscintigraphy) or tissue specific biochemical agents (Receptor imaging) and especially physiologic imaging with positron emitters (PET), have ...

[ 44 ] - Evaluation of ocular hydroxyapatite implant with Tc-99m MDP bone scan [Persian]

Static bone scan was performed in 46 patients for evaluation of ocular Hydroxyapatite Vascularization. Study Findings indicated that bone scan, with TC-99m MDP is an appropriate method for evaluation of Hydroxyapatite Vascularization and for estimating the time For peg insertion into the Hydroxyapatite implant. Our study showed proper Hydroxyapatite Vascularization when the ratio of activ...

[ 45 ] - Comparison and evaluation of value of thymoglobulin level in serum and I-131 whole body scan (I-131 WBS) in patients with differentiated thyroid carcinoma [Persian]

  This study was done in research institute of nuclear medicine from 1988-1992 for evaluation of the value of serum thyroglobulin level in comparison with 1-131 whole body scan (1-131 WBS) in patients with differentiated thyroid carcinoma. 204 patients who had total or near total thyroidectomy treated with 1-131 were evaluated in this study. Out of 204 patients 136 di...

[ 46 ] - Localization of ectopic parathyroid adenoma with Tc-99m-MIBI [Persian]

  Ectopic paratliyroid adenoma might create a clinical dilemma in patients with hypercalcemia. Radioisotopic scan is a sensitive and noninvasive method which can be useful in these patients. In this report a case of ectopic parathyroid adenoma is presented and the usefulness of TC-99m-MIBI scintigraphy as compared with other modalities is discussed.

[ 47 ] - Tc-99m-Pertechnetate in evaluation of meckel's diverticulum [Persian]

Meckel's diverticulum is a common congenital disorder which may result in Gl bleeding. For definite diagnosis before surgery, radiographic procedures such as small intestine barium studies are not greatly successful; on the other hand Tc-99m-Pertechnetate imaging is a physiologic and noninvasive method with high sensitivity and specificity. In this report, three patients with rectorrhagia...

[ 48 ] - Diagnostic efficacy of radioisotopic renal scan in evaluation of renal transplants [Persian]

"Abstract is NOT available"

[ 49 ] - 99mtc-Ubiquicidin [29–41], a Promising Radiopharmaceutical to Differentiate Orthopedic Implant Infections from Sterile Inflammation

Ubiquicidin (UBI) [29-41] is a synthetic cationic antimicrobial peptide that preferentially binds to bacterial cell membrane at the site of infection. We aimed to assess diagnostic value of 99mTc-UBI [29-41] as a radiopharmaceutical in differentiation of bacterial infection from sterile inflammation in suspected orthopedic implants. Nine patients suspected for orthopedic implant infection, all ...

[ 50 ] - 99mtc-Ubiquicidin [29–41], a Promising Radiopharmaceutical to Differentiate Orthopedic Implant Infections from Sterile Inflammation

Ubiquicidin (UBI) [29-41] is a synthetic cationic antimicrobial peptide that preferentially binds to bacterial cell membrane at the site of infection. We aimed to assess diagnostic value of 99mTc-UBI [29-41] as a radiopharmaceutical in differentiation of bacterial infection from sterile inflammation in suspected orthopedic implants. Nine patients suspected for orthopedic implant infection, all ...

[ 51 ] - تصویربرداری مولکولی با روش PET/CT در انکولوژی

زمینه: تصویربرداری مولکولی روشی نوین جهت بررسی مستقیم عملکرد سلول در سطح مولکولی بدون ایجاد هیچ‌گونه مداخله و مزاحمتی برای سلول می‌باشد. تصویربرداری مولکولی شامل چندین روش می‌باشد که در میان آنها تصویربرداری (Positron Emission Tomography:PET) که با تصویربرداری (Computed Tomography:CT) توأم شده باشد از ارزش ویژه‎ای در بررسی تومورها برخوردار است. مواد و روش‌ها: در این مطالعه مروری، کارآزمایی‎های ...

[ 52 ] - 18F-FDG PET/CT findings in a possible MELAS syndrome: A case study

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare congenital disorder of mitochondrial DNA, presenting a wide range of clinical symptoms comprising headaches, seizures, aphasia, hearing loss, visual defects, and hemiparesis. Herein we report a case of a previously asymptomatic 40-year-old male who presented with recurrent headache, seiz...

[ 53 ] - Diagnostic efficiency of 68Ga-DOTATATE PET/CT as compared to 99mTc-Octreotide SPECT/CT and conventional morphologic modalities in neuroendocrine tumors

Objective(s): In view of somatostatin receptor (SSR) expression on cell membranes of the majority of neuroendocrine tumors (NETs), functional imaging exploiting analogs of SSR alongside the anatomical imaging is the mainstay of this diagnostic modality. In this prospective study, we assessed and directly compared the diagnostic parameters of 68Ga-DOTATATE PET/CT and 99...

[ 54 ] - 68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors

Objective(s): 68Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of 68Ga-DOTATATE PET/CT and 131I-MIBG single photon emission computed tomography (SPECT)/CT in the initial diagnosis, staging and follow-up of pa...