Mehran Karimi

[ 1 ] - Frequency of Antiphospholipid Antibodies in Iranian Patients with Solid Malignan-cies: A Pilot Study

[ 2 ] - Evaluation of the Serum Levels of Immunoglobulin and Complement Factors in b-thalassemia Major Patients in Southern Iran

Background: Beta-thalassemia major is one of the major health problems in our country. Many studies have confirmed the fact that, these patients have an increased susceptibility to bacterial infections. Objective: In this study, we have assessed the humoral immune system in 68 thalassemic patients by measuring their serum concentration of Immunoglobulin G (IgG), IgM, IgA, C3 and C4 in order to ...

[ 3 ] - Long Term Follow up Study on a Large Group of Patients with Congenital Factor XIII Deficiency Treated Prophylactically with Fibrogammin P®

Factor XIII deficiency (FXIIID) is an extremely rare hemorrhagic disorder with a prevalence of 1/3-5 million. Management of disease is performed by fresh frozen plasma (FFP), Cryoprecipitate (CP) or FXIII concentrate (Fibrogammin P®). Our objective was to assess safety and effectiveness of Fibrogammin P® in patients with FXIIID. For this purpose we designed this long-term follow up study on a l...

[ 4 ] - Long Term Follow up Study on a Large Group of Patients with Congenital Factor XIII Deficiency Treated Prophylactically with Fibrogammin P®

Factor XIII deficiency (FXIIID) is an extremely rare hemorrhagic disorder with a prevalence of 1/3-5 million. Management of disease is performed by fresh frozen plasma (FFP), Cryoprecipitate (CP) or FXIII concentrate (Fibrogammin P®). Our objective was to assess safety and effectiveness of Fibrogammin P® in patients with FXIIID. For this purpose we designed this long-term follow up study on a l...

[ 5 ] - Epidemiology of Hereditary Coagulation Bleeding Disorders: A 15-Year Experience From Southern Iran

Background: Data on the frequency of hereditary bleeding disorders (HBDs) and associated mortality and morbidities during a long-term follow-up from Iran are scarce. Objective: This study evaluated the epidemiologic features among patients with HBD in one of the largest referral centers in southern Iran. Methods: In this cross-secti...

[ 6 ] - Frequency of Celiac Disease in Children with Beta Thalassemia major

Background We aimed to investigate the frequency of celiac disease in children with β-thalassemia major (B-TM) in Shiraz, southern Iran. Materials and Methods In this study, the prevalence of celiac disease in children with B-TM was evaluated. Children with BTM were screened for celiac disease by ant-tissue transglutaminase (anti-tTG) IgA antibody, IgA level and anti-tTG IgG. A total o...

[ 7 ] - Serum cancer antigen 15.3 concentrations in patients with beta-thalassemia minor compared to those with cancer and healthy in-dividuals

  Background :Highserum level of cancer antigen 15.3 (CA15.3) has been reported in some malignant and nonmalignant conditions including thalassemia major which could have been resulted from ineffective erythropoiesis. We aimed to evaluate the serum level of CA15.3 in carriers of beta-thalassemia by comparing them with cancer patients and healthy individuals.   Methods : This cross-sectional stu...

[ 8 ] - بررسی موتاسیون در فاکتور 5‌‌ ـ انعقادی و ژن پروترومبین در جنوب ایران

چکیده : مقدمه و هدف: موتاسیون ارثی فاکتور 5 و پروترومبین اگر چه شایع نیستند، ولی از عوامل دخیل در ترومبوز کودکان به شمار می‌روند. این پژوهش به منظور بررسی موتاسیون در فاکتور 5 ـ انعقادی و ژن پروترومبین در بین بیماران بستری انجام گردید . مواد و روش‌ها: در این مطالعه توصیفی ـ مقطعی 195 نفر بیمار شامل؛ 97 زن و 98 مرد به صورت تصادفی از بین بیماران بستری در بخش‌های مختلف بیمارستان‌های نمازی و...

[ 9 ] - Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea

Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...

[ 10 ] - Diffuse Hepatic Calcifications in a Transfusion-Dependent Patient with Beta-Thalassemia: A Case Report

Hepatic calcification is usually associated with infectious, vascular, or neoplastic processes in the liver. We report the first case of beta-thalassemia major with isolated diffuse hepatic calcification in a 23 year old woman, who had been transfusion-dependent since the age of 6 months. She was referred to our center with a chief complaint of abdominal pain. Computed tomography scan of the ab...

[ 11 ] - Non-Hodgkin Lymphoma in a Child with Schimke Immuno-Osseous Dysplasia

Schimke immuno-osseous dysplasia is a rare autosomal recessive multisystem disorder characterized by steroid-resistant nephrotic syndrome, immunodeficiency, and spondyloepiphy-seal dysplasia. Mutations in SWI/SNF2 related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1) gene are responsible for the disease. The present report describes, for the f...

[ 12 ] - Possible Association between Glucose-6-Phosphate Dehydrogenase Deficiency and the Development of Preeclampsia

Glucose-6-Phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency in the world. It's Prevalence inIranis about 12% in male & about 1% in female. The present study did examine the relation between the development of preeclampsia and G6PD deficiency. It was investigated whether or not the risk of preeclampsia in G6PD deficient women is higher than that in normal pregnant women.A t...

[ 13 ] - Leukemic Infiltration of the Appendix as an Unusal Site of Extramedulary Relapse: Report of Two Cases and Review of the Literature

The appendix is an unusual site for extramedulary relapse in acute leukemia. The present case report describes two cases of late course acute lymphoblastic leukemia presented with leukemic infiltration of the appendix and complete remission of bone marrow. The signs and symptoms of the cases suggest that leukemic involvement of the appendix should be considered in the differential diagnosis of ...

[ 14 ] - Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran

Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of ...

[ 15 ] - Hemoaction game: an educational step to improve hemophilia children and nurses self-efficacy

As hemophilia is a chronic bleeding diseaseand can interfere with daily performanceof children, these children require continuoustraining to prevent bleeding and take timely action(1). Since children nurses play an important role inthe education of involved children and their Selfefficacyand also due to today’s approach whichis using educational computer games, the use ofeducational games in re...

[ 16 ] - Development and Initial Validation of the Scale of Knowledge, Attitude, Intention and Performance in Drug Abuse in Iranian Elderly Society

Objective: The present study aimed to develop and initially validate the scale of awareness) knowledge(, attitude, intention and performance in elderly with a history of drug substance in Iranian society in 2018. Method: This research was descriptive-correlational of instrument validation type. The statistical population included all elderly addicts referring to the center for rural health soci...