Mohammad Motamedifar
Department of Bacteriology and Virology | Shiraz HIV/AIDS Research Center (SHARC)
[ 1 ] - Symptomatic Reactivation of HSV Infection Correlates with Decreased Serum Levels of TNF-α
Background: Herpes simplex viruses (HSV) are human pathogens that establish lytic and latent infections. Reactivation from latency occurs intermittently, which represents a life-long source for recurrent infection. The role of immune factors in the control of recurrent symptomatic HSV lesions is complex and the exact role of cytokines remains unclear. Objective: To assess the levels of tumor ne...
[ 2 ] - Seroprevalence of Varicella-Zoster Virus in Children from Shiraz-Iran
Background: Varicella–zoster virus (VZV) causes herpes zoster and varicella (Chicken-pox), usually a mild disease which is diagnosed clinically with few complications. However, in neonates and healthy adults it can have a severe presentation. Herpes zoster results from VZV reactivation later in life. Objective: To determine the seroprevalence of VZV in elementary school children aged 6-10 years...
[ 3 ] - Proteolytic activity and cooperative hemolytic effect of dermatophytes with different species of bacteria
Background and Purpose: Globally, dermatophytes are the most common filamentous group of fungi causing cutaneous mycoses. Dermatophytes were shown to secrete a multitude of enzymes that play a role in their pathogenesis. There is limited data on co-hemolytic (CAMP-like) effect of different bacterial species on dermatophyte species. In this study, we sought to the evaluate exoenzyme activity an...
[ 4 ] - The study of seroprevalence of human cytomegalovirus in healthy blood donors referring to Fars blood bank
Introduction: Human cytomegalovirus (HCMV) infection is most often asymptomatic in immuno-competent individuals and has lifelong latency especially in leukocytes. However, CMV is a major cause of infection and death in immuno-compromised patients. Transfusion transmitted HCMV (TT-HCMV) can cause serious morbidity and mortality in certain patients who are at risk. In this study, we evaluated t...
[ 5 ] - The Frequency of Exotoxin A and Exoenzymes S and U Genes Among Clinical Isolates of Pseudomonas aeruginosa in Shiraz, Iran
Pseudomonas aeruginosa as an opportunistic pathogen produces several virulence factors. The most important of these factors are exotoxin A and type III secretion system (T3SS). The aim of this study was to determine the frequency of toxA, exoU and exoS genes among clinical isolates of P. aeruginosa. In this cross-sectional study from September 2011 to February 2012, 156 P. aeruginosa isolates w...
[ 6 ] - مقایسه مقاومت آنتی‌بیوتیکی و فراوانی ژن‌های حدت در اشریشیا کلی‌های ادراری و مدفوعی افراد مبتلا به عفونت دستگاه ادراری
زمینه و هدف: عفونت‌های دستگاه ادراری یکی از مهم‌ترین عفونت‌های باکتریایی هستند و شایع‌ترین عامل این عفونت‌ها باکتری اشریشیا کلی می‌باشد. با توجه به اهمیت اشریشیا کلی‌های فلور طبیعی دستگاه گوارش در ایجاد عفونت ادراری، مطالعه حاضر به منظور مقایسه اشریشیا کلی‌های عامل عفونت دستگاه ادرای با اشریشیا کلی‌های غالب فلور طبیعی دستگاه گوارش براساس مقاومت آنتی‌بیوتیکی و برخی ژن‌های حدت انجام گرفت. روش...
[ 7 ] - مقایسه دو روش الیزا و واکنش زنجیره ای پلی مراز نستد در تشخیص آلودگی به ویروس سیتومگال انسانی
مقدمه و هدف: عفونت ویروس سیتومگال انسانی در افراد عادی معمولا بدون علامت و با نهفتگی مادام العمر است، اما نقصان در عملکرد سیستم ایمنی سبب فعال شدن ویروس می گردد. این ویروس عاملی مهم در مرگ و میر بعضی از بیماران نیازمند دریافت خون می باشد. هدف از این مطالعه مقایسه دو روش الیزا و واکنش زنجیره ای پلی مراز نستد در تشخیص آلودگی به ویروس سیتومگال انسانی بود. مواد و روش ها: در این مطالعه تحلیلی تعداد...
[ 8 ] - Isolation of Methicillin-Resistant Staphylococcus aureus (MRSA) from HIV Patients Referring to HIV Referral Center, Shiraz, Iran, 2011-2012
Extension of drug resistant Staphylococcus aureus strains is one of the problems of modern society. Presence of methicillin-resistant Staphylococcus aureus (MRSA) in HIV-infected individuals is an important cause of severe infections. Therefore, the main goal of this study was to determine the prevalence rate of MRSA carriage rate among HIV patients referring to the Shiraz HIV referral center (...
[ 9 ] - The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012
Evidence has shown that liver disease caused by hepatitis viruses can be more aggressive and severe in HIV infected subjects. Therefore, the present cross-sectional study aimed to evaluate the seroprevalence of HDV infection among HIV/HBV co-infected clients in Shiraz, southwest Iran. In this study, 178 patients co-infected with HBV and HIV individuals were enrolled. The diagnosis of HIV infect...
[ 10 ] - Polymerase Chain Reaction, Bacteriologic Detection and Antibiogram of Bacteria Isolated from Otitis Media with Effusion in Children, Shiraz, Iran
Background: Otitis media with effusion is one of the leading causes of hearing loss in children. Effective treatment of effusion in the middle ear requires appropriate empirical treatment and characterization of responsible pathogens. Objective of the present study was to detect pathogens in clinical samples from patients with otitis media with effusion in our area and to determine the sensitiv...
[ 11 ] - The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture
Background: Cumin (Cuminum cyminum L. [family Apiaceae]) seed essential oil is reported to have antiseptic activity. Until now the antiviral properties of cumin seed extracts on viruses such as herpes simplex virus-1 (HSV-1) have not been studied. The objective of this study was to investigate the in vitro effects of aqueous, methanolic and hydroalcoholic extracts of cumin seed on HSV-1 growth ...
[ 12 ] - Estimation of the Cultured Cells’ Volume and Surface Area: Application of Stereological Methods on Vero Cells Infected by Rubella Virus
Background: Morphological changes of the cells infected with rubella virus cannot be observed easily. Estimation of the size of the cultured cells can be a valuable parameter in this condition. This study was conducted to find answers to the following questions:How much time after infection with rubella virus, the volume and surface area of the Vero cells and their nuclei get started to change?...
[ 13 ] - The Effect of Pre-exposure to Radiofrequency Radiations Emitted from a GSM Mobile Phone on the Suseptibility of BALB/c Mice to Escherichia coli
Background: Pre-exposure to radiofrequency radiations of mobile phones would significantly increase the survival rate of exposed animals compared to those exposed to a lethal dose of gamma radiation alone. Stimulation of the immune system is believed to be a key mechanism for the induction of this phenomenon, the so-called “adaptive response.†The immune system protects organisms against in...
[ 14 ] - The first report of Enterobacter gergoviae carrying blaNDM-1 in Iran
Objective(s): Prompt detection of extended-spectrum β-lactamases (ESBL) and carbapenemase-producing enterobacteriaceae is crucial for infection prevention and control strategies. The present study aimed to characterize the ESBL and carbapenemase genes among Enterobacter isolates from an Iranian inpatient population.Materials and Methods:...
[ 15 ] - Salivary Streptococcus mutans and Lactobacilli Levels as Indicators of Dental Caries Development in Iranian Patients with Systemic Sclerosis
Background and Objective: Systemic sclerosis is an autoimmune disorder with orofacial manifestations, including tooth decay. Lactobacilli can inhibit biofilm formation and growth of cariogenic pathogens, such as Streptococcus mutans. We aimed to assess the salivary levels of S. mutans and Lactobacilli as indicators of dental caries development in patients with systemic sclerosis. Methods: In t...
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