Mehdi Abaszadeh

[ 1 ] - Multi-component preparation of diethyl/methyl 1,3-diaryl-1,2,3,6-tetrahydro-pyrimidine-4,5-dicarboxylates using hydrated phosphomolybdic acid as an efficient catalyst

The synthesis of diethyl/methyl 1,3-diaryl-1,2,3,6-tetrahydro-pyrimidine-4,5-dicarboxylates can be achieved using one-pot reaction from dialkylacetylene dicarboxylate, amines, and formaldehyde by employing hydrated phosphomolybdic acid (H3[P(Mo3O10)4].xH2O) as catalyst at room temperature. The effect of various solvent and catalyst amount was investigated. The salient features of the present me...

[ 2 ] - KF/Al2O3: As a Solid Phase and Recyclable Basic Catalyst for Synthesis Mono and Bis Pyrimidine Derivatives

KF/Al2O3 as a green and efficient catalyst has been used for the synthesis of mono and bis pyrimidine derivatives via three-component reaction of amidines, malononitrile, and aldehydes in EtOH at reflux. The great advantage of this catalyst is the ease of handling. KF/Al2O3 can be used and removed by filtration, avoid cu...

[ 3 ] - Design, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents

A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile...

[ 4 ] - Design, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents

A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile...

[ 5 ] - Multi-component preparation of diethyl/methyl 1,3-diaryl-1,2,3,6-tetrahydro-pyrimidine-4,5-dicarboxylates using hydrated phosphomolybdic acid as an efficient catalyst

The synthesis of diethyl/methyl 1,3-diaryl-1,2,3,6-tetrahydro-pyrimidine-4,5-dicarboxylates can be achieved using one-pot reaction from dialkylacetylene dicarboxylate, amines, and formaldehyde by employing hydrated phosphomolybdic acid (H3[P(Mo3O10)4].xH2O) as catalyst at room temperature. The effect of various solvent and catalyst amount was investigated. The salient features of the present me...

[ 6 ] - Evaluation of Mechanical Properties of Flowable Dental Composites Containing Antibacterial Compound

Abstract Background and Aims: The purpose of this study was to evaluate the mechanical properties of flowable dental composites containing the antibacterial compound. Materials and Methods: The study was conducted through experimental design. Compound 3- (2,5-Dimethylfuran-3-yl) -1H-pyrazol-5- (4H)-one were synthesized using Ethyl chloroformate, hydrazine hydrate and 3-acetyl-2,5-dimethylfur...