Manizheh Karami
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
[ 1 ] - Blockade of the Naloxone-induced Aversion in Morphine-conditioned Wistar Rats by L-Arginine Intra-central Amygdala
Objective(s) Single injection of naloxone, a selective antagonist of morphine, prior to the drug conditioning testing was used to investigate on morphine dependence. Materials and Methods Conditioning to morphine (2.5-10 mg/kg, s.c.) was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedure. Nitric oxide agents were microinjected into the central amygdala pri...
[ 2 ] - ایجاد تخمدان چند کیستیک در موش آزمایشگاهی بزرگ با مرفین
Background and Objective: Morphine is clinically a strong analgesic drug and in view of substances abusing is a hazardous drug. Besides dozens of unknown facts, the morphine side effects are unknown on the reproductive system. This study aimed to provide a reliable document in relation to its power to induce the follicular cysts in rat. Materials and Methods: Virgin female Wistar r...
[ 3 ] - تاثیر گالانتامین بر برگشت فعالیت حرکتی تشدید یافته در اثر میکرواینجکشن کلشی سین در هیپوکامپ موش ویستار
Background and Objective: Deleterious effect of neurotoxins on the brains of animals is an attractive research topic. In this research, the effect of microinjection of colchicine into the hippocampal CA1 was shown by examining the novelty seeking behavior. Also, the effect of pre-injection of galantamine, an effective agent in the treatment and prevention of Alzheimer's disease, for reversal of...
[ 4 ] - تقابل اثر نالوکسان با ناباروری القایی سیستم نیتریک اکساید در مدل حیوانی تخمدان پلی‌کیستیک
Background and Objective: Evidence exist that polycystic ovarian syndrome (PCOS) is responsible for a high percentage of women infertility during reproductive age. In this study, the correction of this problem by hyper-activation of nitric oxide (NO) system was studied in rats. Materials and Methods: Female Wistar rats (weighing 200-250 g) were kept as virgin diestrous under standard condit...
[ 5 ] - Reversal Effect of Intra-Central Amygdala Microinjection of L-Arginine on Place Aversion Induced by Naloxone in Morphine Conditioned Rats
Background: Role of nitric oxide (NO) on expression of morphine conditioning using a solely classic task has been proposed previously. In this work, the involvement of NO on the expression of opioid-induced conditioning in the task paired with an injection of naloxone was investigated. Methods: Conditioning was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedu...
[ 6 ] - Verifying of Participation of Nitric Oxide in Morphine Place Conditioning in the Rat Medial Septum Using Nicotinamide Adenine Dinucleotide Phosphate-Diaphorase (NADPH-d)
Background: Role of nitric oxide (NO) in morphine-induced conditioned place preference (CPP) has already been proposed in the rat medial septum (MS), but no molecular evidence has been provided to clear this fact. Methods: Effects of intraseptal injections of L-arginine and/or NG-nitro-L-arginine methyl ester (L-NAME) on morphine place conditioning in Wistar rats were examined. Morphine (2.5-7....
[ 7 ] - Response to Morphine in a unicellular animal model (Paramecium caudatum)
Introduction: Response to morphine and role of Nitric Oxide (NO) on expression of morphine response has been studied in vertebrates. But, little evidence is provided in the matter in earlier invertebrates. This investigation for the first time evaluated the effect of NO on expression of morphine potency in Paramecium caudatum. Methods: Animal after isolation from natural media and specific i...
[ 8 ] - Interaction of colchicine with nitric oxide in CA1 on the expression of drug seeking behavior induced by morphine
Introduction: According to previous studies, colchicine causes neuronal destruction and learning depression. In this project, effects of colchicine injection into the CA1 and interaction between colchicine and nitric oxide (NO) in this area on the expression of drug-seeking behavior were investigated. Methods: Wistar rats (250-300 g) were bilaterally cannulated at the CA1 area. Colchicine (2...
[ 9 ] - Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat
Background and Objective: Morphine can cause harmful effects in the ovaries. The silver nanoparticles (Ag-NPs) used in health care because of antimicrobial properties, can diffuse into the brain blood barrier. This study investigated the protective effect of Ag-NPs on the induction of polycystic ovary (PCO) due to injection of morphine intra-ventromedial hypothalamus (intra-VMH) of rat compared...
[ 10 ] - Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum
Objective(s): With no substantial cost, we injected L-arginine into the rat’s corpus callosum (CC) to create animal model of multiple sclerosis (MS) and investigated the pre-injection effect of gold nanoparticles (GNPs). Materials and Methods: Adult male Wistar rat (250-300 g) was surgically cannulated at the CC, and after recovery it was injected L-arginine (3-200 µg/rat, intra-CC) once ...
[ 11 ] - اثر مهار رسپتور mu اپیوئیدی در هسته میانی- شکمی هیپوتالاموس بر کیست‌زایی تخمدانی القا شده با مورفین در موش آزمایشگاهی بزرگ
مقدمه و هدف: مورفین اثرات نامطلوبی بر دستگاه تولید مثلی مادینه دارد. این پژوهش اثرات تداخلی MgSO4 و نالوکسان را در هسته میانی شکمی هیپوتالاموس(VMH) موش بزرگ آزمایشگاهی (رت) با تخمدان‌های پلی‌کیستیک )القا شده با مورفین( بررسی می نماید. مواد و روش کار: 80 سر موش ماده (۲۰۰-۲۵۰ گرم) تحت شرایط استاندارد نگهداری و با دستگاه استرئوتاکس (در مختصات -۱/۹۲ :AP، ۹ :V و ۰/۵ :L) جراحی شدند و بعد از بهبود، ...
[ 12 ] - Ethanol impairs memory by reducing the synaptic connection of the hippocampal spatial neurons
Background and Objective: Ethanol has undesirable effects on memory and synaptic communication. However, its impact on the learned spatial memory is unclear. We investigated the damaging effects of ethanol on place neurons of rat’s hippocampal CA1.Materials and Methods: Sixty four male Wistar rats (250 g) were administered high (1-8 g/kg) or low (0.05-0.1 g/kg) doses of ethanol intraperit...