Layasadat Khorsandi

[ 1 ] - Immunolocalization of Galectin-3 in Mouse Testicular Tissue

Objective(s) Galectin-3 (Gal-3) is a member of the B-galactoside-binding lectins which is expressed in a variety of tissues and plays a role in diverse biological events, such as embryogenesis, adhesion, cellular proliferation, and apoptosis. In this study, the presence and distribution of galectin-3 (Gal-3) in the mouse testicular tissue was investigated. Materials and Methods Eight adult N...

[ 2 ] - Grape Seed Proanthocyanidin Extract Improved some of Biochemical Parameters and Antioxidant Disturbances of Red Blood Cells in Diabetic Rats

Grape seed proanthocyanidin extract (GSPE) has a broad spectrum of biologic properties against oxidative stress. This study aimed to investigate the effects of GSPE on biochemical factors and antioxidant enzymes of erythrocyte in diabetic rats. Diabetes was induced through single injection of streptozotocin (50 mg.kg-1, i.p). Forty Male Sprague-Dawley rats were divided into four Groups: Group 1...

[ 3 ] - Curcumin-loaded poly lactic-co-glycolic acid nanoparticles effects on mono-iodoacetate -induced osteoarthritis in rats

Curcumin has been found to be very efficacious against many different types of diseases. However, the major disadvantage associated with the use of curcumin is its low systemic bioavailability. In the present study the protective effects of curcumin-loaded poly lactic-co-glycolic acid nanoparticles (nanocurcumin) against mono-iodoacetate-induced osteoarthritis in rats was inves...

[ 4 ] - Protective role of grape seed proanthocyanidin antioxidant properties on heart of streptozotocin-induced diabetic rats

Grape seed proanthocyanidin (GSP) bears a very powerful antioxidant effects. Studies demonstrated that proanthocyanidins protect against free radicals mediated cardiovascular and renal disorders. The present study was designed to assess the effect of GSP on the heart of diabetic rats. Forty rats were divided into four groups of 10 animals each: Group I: control, Group II: control group were giv...

[ 5 ] - Grape Seed Proanthocyanidin Extract Improved some of Biochemical Parameters and Antioxidant Disturbances of Red Blood Cells in Diabetic Rats

Grape seed proanthocyanidin extract (GSPE) has a broad spectrum of biologic properties against oxidative stress. This study aimed to investigate the effects of GSPE on biochemical factors and antioxidant enzymes of erythrocyte in diabetic rats. Diabetes was induced through single injection of streptozotocin (50 mg.kg-1, i.p). Forty Male Sprague-Dawley rats were divided into four Groups: Group 1...

[ 6 ] - بررسی بیان پروتئین Bax در آپوپتوز ناشی از دگزامتازون در سلولهای زایای اسپرم در موش آزمایشگاهی

سابقه و هدف: مطالعات نشان داده است که گلوکوکورتیکوئیدها هموستاز بیضه را با کاهش دادن سطح تستوسترون تحت تاثیر قرار می دهند. در این مطالعه اثر دگزامتازون، به عنوان یک ترکیب گلوکوکورتیکوئیدی پر مصرف، بر بیان پروتئین Bax در سلولهای زایای اسپرم و فرآیند اسپرماتوژنزیس در موش های آزمایشگاهی بررسی شد.روش بررسی: در این مطالعه تجربی، 35 موش بالغ نر بطور تصادفی به 5 گروه تقسیم شدند. موش های گروه شاهد تنها...

[ 7 ] - اثر محافظتی عصاره زردچوبه (Curcuma longa) در مسمومیت کبدی حاد ناشی از استامینوفن در موش آزمایشگاهی

Background and Objective: Acetaminophen is widely used as an analgesic and antipyretic drug, and when given in high doses can causes hepatic and renal injury in both human and animal. The liver damage in form of centrilobular necrosis is induced by using acetaminophen, depends on the cytochrome P-450 activities. In the present study hepatoprotective effects of Curcuma longa extract on hepatic i...

[ 8 ] - اثر عصارة چای سبز (Camellia sinensis L.) بر مسمومیت حاد کبدی ناشی از استامینوفن در موش سوری

با توجه به تجویز روزانه مقادیر زیادی از داروها توسط پزشکان؛ در سالهای اخیر توجه زیادی به اثر گیاهان در درمان و پیشگیری مسمومیت ناشی از داروها معطوف شده است. چای سبز (Camellia sinensis L.) نوشیدنی مرسوم در دنیا می‌باشد و دارای خواص آنتی‌اکسیدان و سم‌زدایی می‌باشد. در تحقیق حاضر اثر محافظتی عصاره چای سبز در مسمومیت کبدی حاد ناشی از استامینوفن مورد بررسی قرار گرفته است. به‌طوری که 32 موش سوری نر ب...

[ 9 ] - The effects of Dexamethasone on Galectin-3 expression in the mouse testicular tissue

Background : Previous studies have demonstrated that Dexamethasone, a widely used GC, induces apoptosis in testis by decreasing the testosterone levels. Galectin-3 (Gal-3), a member of the ß-galactoside-binding lectins, plays critical roles in diverse biological events including cell growth, apoptosis, cell adhesion and immunomodulation. In this study, the effects of Dexamethasone (Dex) on gale...

[ 10 ] - تاثیر تمرین تناوبی شدید و کروسین بر استرس اکسیداتیو بافت قلب رت های نر در معرض القاء دوکسوروبیسین

زمینه و هدف: بیماری های قلبی عروقی از دلایل عمده مرگ و میر در دنیا می باشد. استرس اکسیداتیو نقش عمده ای در بروز و توسعه بیماری های قلبی عروقی دارد. فعالیت بدنی وضعیت آنتی اکسیدانی بافت قلب را بهبود می بخشد. هدف از پژوهش حاضر، بررسی سطوح شاخص های اکسیدانی و آنتی اکسیدانی بافت قلب رتهای نر قرارگرفته در معرض دوکسوروبیسین، پس از هشت هفته تمرین تناوبی شدید و مصرف کروسین بود. روش بررسی: در یک کارآ...

[ 11 ] - اثر دگزامتازون بر بیان پروتئین FasL در سلول‌های زایای اسپرم در بیضه‌ی موش سوری

Background and Objectives: Apoptosis (programmed cell death) is an important regulatory event in spermatogenesis. Abnormally accelerated apoptosis in germ cells, may lead to an imbalance between cell proliferation and death, resulting in impairment in spermatogenic. Some studies have shown that glucocorticoids affect testialar homeostasis by decreasing of testosterone level. In the present stud...

[ 12 ] - Effect of High-Intensity Interval Training and Crocin on Hematological Parameters in Doxorubicin-Induced Male Rats

Background: Doxorubicin (DOX) is an anthracyclines antibiotic and is one of the most effective antitumor drugs. However, using this drug is associated with poisoning of healthy tissues. The purpose of this study was to investigate the changes in hematological parameters of male rats exposed to doxorubicin after eight weeks of high-intensity interval training and crocin consumption. Materials a...

[ 13 ] - Protective Effects of Aerobic Training and Crocin on Doxorubicin Induced Heart Tissue Oxidative Stress in Male Rats

Background and Objectives: Doxorubicin-increased oxidative stress destroys tumors and normal cells, especially in heart tissues. The objective of the present study was to investigate effects of eight weeks of aerobic training and crocin consumption on doxorubicin induced heart tissue oxidative stress in male rats. Materials & Methods: In this experimental study, 50 male rats were randomly div...