Aliakbar Taherian

[ 1 ] - Different Expression of Extracellular Signal-Regulated Kinases (ERK) 1/2 and Phospho-Erk Proteins in MBA-MB-231 and MCF-7 Cells after Chemotherapy with Doxorubicin or Docetaxel

Objective(s) Curative treatment of breast cancer patients using chemotherapy often fails as a result of intrinsic or acquired resistance of the tumor to the drug. ERK is one of the main components of the Ras/Raf/MEK/ERK cascade, which mediates signal from cell surface receptors to transcription factors to regulate different gene expression. In this study, cytotoxicity and the expression of Erk...

[ 2 ] - Variations in Intraplatelet Phospho-VASP Expression Due to Pre-analytical Sample Preparations, Illustration of a Quality Control Issue in Platelet Pharmacology

Intraplatelet phospho-VASP analysis is a commonly used approach for monitoring of anti-platelet therapy; however, testing of intraplatelet phospho-VASP expression needs a high level of experience and proficiency. The ability to recognize how the pre-analytical variations can change the results would be helpful for the interpretation of data from intraplatelet P-VASP analysis. The aim of this st...

[ 3 ] - Variations in Intraplatelet Phospho-VASP Expression Due to Pre-analytical Sample Preparations, Illustration of a Quality Control Issue in Platelet Pharmacology

Intraplatelet phospho-VASP analysis is a commonly used approach for monitoring of anti-platelet therapy; however, testing of intraplatelet phospho-VASP expression needs a high level of experience and proficiency. The ability to recognize how the pre-analytical variations can change the results would be helpful for the interpretation of data from intraplatelet P-VASP analysis. The aim of this st...

[ 4 ] - واکنش متفاوت ایزوفرم های آلفا و بتای پروتئین حرارتی 90 با سوبستراهای مختلف

سابقه و هدف: کمپلکس پروتئین حرارتی 90 (HSP90) در فرآیند تولید ساختمان نهایی از قبیل چین خوردگی و فعال شدن پروتئین های بسیاری شرکت دارد. دو پروتئین هومولوگHSP90α ، HSP90βدر مهره داران وجود دارند. نحوه بیان آنها در شرایط نرمال و شرایط استرس با یکدیگر فرق می کند، اما در مورد تمایز عملکرد آنها هنوز کار زیادی انجام نگرفته است. در این کار تفاوت بین ایزوفرم های HSP90 در رابطه با کمپلکس چپرونی مورد برر...

[ 5 ] - Expression of hsp90 Alpha and hsp90 Beta during Xenopus laevis Embryonic Development

Background: Members of the eukaryotic Hsp90 family function as important molecular chaperones in the assembly, folding and activation of cellular signaling in development. Two hsp90 genes, hsp90 alpha and hsp90 beta, have been identified in fish and homeothermic vertebrates but not in poikilothermic vertebrates. In the present study, the expression of hsp90 alpha and hsp90 beta genes in Xenopus...