Naser Naghdi
Department of Physiology and Pharmacology, Institute Pasture of Iran, Tehran, Iran
[ 1 ] - The effects of tramadol on norepinephrine and MHPG releasing in locus coeruleus in formalin test in rats: a brain stereotaxic study
Objective(s):The relationship between tramadol, as an antinociceptive drug, and locus coeruleus (LC), the main noradrenergic nucleus of the brain that affects regulation and modulation of pain through descending noradrenergic pathways was investigated. Materials and Methods: Male Sprague-Dawley rats were divided into four groups of 10 rats. The rats were fixed in stereotaxic instrument and then...
[ 2 ] - Evaluation of Sorbitol-Methanol Co-Feeding Strategy on Production of Recombinant Human Growth Hormone in Pichia Pastoris
Recombinant protein production in Pichia pastoris is based on alcohol oxidase promoterswhich are regulated by methanol. However, the use of methanol has several disadvantages,which is why current trends in bioprocess development with Pichia pastoris (P. pastoris) arefocusing on methanol mixed feeding strategies. This work aimed to develop a new experimentalmethod and compare the effect of vario...
[ 3 ] - Evaluation of Sorbitol-Methanol Co-Feeding Strategy on Production of Recombinant Human Growth Hormone in Pichia Pastoris
Recombinant protein production in Pichia pastoris is based on alcohol oxidase promoterswhich are regulated by methanol. However, the use of methanol has several disadvantages,which is why current trends in bioprocess development with Pichia pastoris (P. pastoris) arefocusing on methanol mixed feeding strategies. This work aimed to develop a new experimentalmethod and compare the effect of vario...
[ 4 ] - Focal Injection of Ethidium Bromide as a Simple Model to Study Cognitive Deficit and Its Improvement
Introduction: Memory and cognitive impairments are some of devastating outcomes of Multiple Sclerosis (MS) plaques in hippocampus, the gray matter part of the brain. The present study aimed to evaluate the intrahippocampal injection of Ethidium Bromide (EB) as a simple and focal model to assess cognition and gray matter demyelination. Methods: Thirty Wistar rats were divided into three groups:...
[ 5 ] - تأثیر تغییر در ویژگیهای مختلف حرکات دو دست بر انتقال حرکت دودستی نامتقارن به الگوی عکس
اندام مجری از حافظه حرکتی در حرکات نامتقارن دودستی به تفاوت در ویژگیهای خاص حرکت دودست بستگی دارد و نیاز به بازنگری دارد.هدف پژوهش حاضر ارزیابی تاثیر تغییر در ویژگیهای مختلف حرکات دو دست بر انتقال حرکت دودستی نامتقارن به الگوی عکس بود و به بررسی فرضیه‌ی استقلال اندام مجری از حافظه حرکتی پرداخته شد.ابزار مورد استفاده در پژوهش حاضر شامل قلم نوری با حسگر ویژه، لپتاپ، دستکش ویژه و مترونوم بود. آزم...
[ 6 ] - تأثیر تجویز سیستمیک انسولین بر حافظه و یادگیری فضایی موش های صحرایی نر
هدف از این پژوهش، تعیین تأثیر تجویز صفاقی انسولین بر عملکرد حرکتی موشهای صحرایی در ماز آبی می‌باشد. برای این منظور، تعداد 40 سر رت نر از نژاد آلبینو ویستار به‌صورت تصادفی در چهار گروه آزمایشی قرار گرفتند (هر گروه 10 سر رت). تزریق انسولین در چهار دوز (صفر، یک، شش و 12 واحد برکیلوگرم) و درطول یک هفته (روزانه یک‌بار) انجام شد. آموزش و آزمون حیوانات با استفاده از ماز آبی موریس صورت گرفت. جهت تحلی...
[ 7 ] - The role of hippocampal nitric oxide in passive avoidance learning
Abstract: Introduction: Nitric oxide (NO) is a retrograde messenger in hippocampal synaptic plasticity which involves in learning and memory processes. Previous studies revealed that hippocampal pyramidal cells contain NO synthase (NOS) enzyme which produce NO and could be a promising target to evaluate the role of NO in brain cognitive functions. So in this study, using NOS inhibitor (L-NAME)...
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